The Future of Adverse Outcome Pathways: Analyzing their Social Context

2018 ◽  
pp. 391-404
Author(s):  
Kevin C. Elliott ◽  
Cheryl A. Murphy ◽  
Natàlia Garcia-Reyero
Keyword(s):  
Social Context ◽  
Adverse Outcome ◽  
The Future ◽  
Adverse Outcome Pathways

scholarly journals AOPs SÃO O FUTURO DA ECOTOXICOLOGIA?

Química Nova ◽  
2021 ◽  
Author(s):  
Paula Suares‑Rochaa ◽  
Gisela Umbuzeiro
Keyword(s):  
Adverse Effects ◽  
Molecular Level ◽  
Adverse Outcome ◽  
Biological Systems ◽  
Action Plans ◽  
Basic Principles ◽  
Chemical Substances ◽  
The Future ◽  
Toxic Potential ◽  
Adverse Outcome Pathways

ARE AOPs THE FUTURE OF ECOTOXICOLOGY? AOPs (Adverse Outcome Pathways) were introduced in the field of ecotoxicology due to the need of replacement of the classic system for assessing adverse results (considering only the mortality of organisms exposed to certain substances or mixtures) to a predictive system based on the measurement of biological events occurring primarily at a molecular level and having clear biological relationships with potential adverse effects on more complex biological systems. AOPs are useful for organizing and integrating information related to the toxic potential of chemical substances alone or in mixtures, in exposed organisms, supporting the prediction and understanding of the effects induced by stressors and the development of action plans in order to reduce the exposure of organisms to acceptable levels. This tool is already gaining strength and being used worldwide by scientists, and in the future it may be the basis for the regulation of chemical substances and their mixtures. This article presents the basic principles related to the development and use of an AOP, in a simple and objective way, in addition to presenting practical example of this tool, which can be considered the future of ecotoxicology

scholarly journals The future trajectory of adverse outcome pathways: a commentary

2018 ◽  
Vol 92 (4) ◽  
pp. 1657-1661 ◽  
Author(s):  
Fiona Sewell ◽  
Nichola Gellatly ◽  
Maria Beaumont ◽  
Natalie Burden ◽  
Richard Currie ◽  
...  
Keyword(s):  
Adverse Outcome ◽  
The Future ◽  
Adverse Outcome Pathways

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

2011 ◽  
pp. n/a-n/a ◽  
Author(s):  
Gerald T. Ankley ◽  
Richard S. Bennett ◽  
Russell J. Erickson ◽  
Dale J. Hoff ◽  
Michael W. Hornung ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Conceptual Framework ◽  
Adverse Outcome ◽  
Adverse Outcome Pathways

scholarly journals An Update on Adverse Outcome Pathways Leading to Liver Injury

2017 ◽  
Vol 3 (4) ◽  
pp. 283-285 ◽  
Author(s):  
Eva Gijbels ◽  
Mathieu Vinken
Keyword(s):  
Liver Injury ◽  
Adverse Outcome ◽  
Adverse Outcome Pathways

Adverse outcome pathways, key events, and radiation risk assessment

2020 ◽  
pp. 1-18
Author(s):  
R. Julian Preston ◽  
Werner Rühm ◽  
Edouard I. Azzam ◽  
John D. Boice ◽  
Simon Bouffler ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Adverse Outcome ◽  
Radiation Risk ◽  
Key Events ◽  
Adverse Outcome Pathways

Adverse Outcome Pathways Knowledge Base (AOP-KB)

2015 ◽  
Vol 238 (2) ◽  
pp. S309
Author(s):  
C. Wittwehr ◽  
S. Munn ◽  
B. Landesmann ◽  
M. Whelan
Keyword(s):  
Knowledge Base ◽  
Adverse Outcome ◽  
Adverse Outcome Pathways
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