HARP (Heparin Affinity Regulatory Peptide)

2018 ◽  
pp. 2317-2317
Keyword(s):  
Regulatory Peptide ◽  
Heparin Affinity

Circulating Activities During Constant Infusion of Heparin or a Low Molecular Weight Derivative (Enoxaparine): Failure to Demonstrate any Circadian Variations

1987 ◽  
Vol 58 (04) ◽  
pp. 1068-1072 ◽  
Author(s):  
P Toulon ◽  
J F Vitoux ◽  
C Leroy ◽  
T Lecomte ◽  
M Roncato ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Circadian Rhythm ◽  
Biological Activities ◽  
Constant Infusion ◽  
Low Molecular Weight ◽  
Circadian Variations ◽  
Heparin Cofactor Ii ◽  
Heparin Infusion ◽  
Chromogenic Assay ◽  
Heparin Affinity

SummaryWe compared in six patients successively treated with an unfractionated heparin (UFH) and a low molecular weight heparin (LMWH) the variations in plasma anti-Xa activity, measured in a chromogenic assay, during a 36 h constant infusion. The values varied in a wider range during UHF infusion, but remained in the therapeutic range except once in one patient. No circadian rhythm could be demonstrated in our six patients. LMWH infusion yielded very constant anti-Xa circulating activities. In both cases, there were no significant modifications of three proteins with high heparin affinity (antithrombin III, heparin cofactor II, histidine-rich glycoprotein).Our results suggest that the circadian rhythm of the biological activities previously observed in patients treated with constant heparin infusion using clotting method is due to other factors than heparin itself.

Simulation of mono-PEGylated lysozyme separation in heparin affinity chromatography using a general rate model

2017 ◽  
Vol 93 (7) ◽  
pp. 1980-1987 ◽  
Author(s):  
Luis Alberto Mejía-Manzano ◽  
Gabriela Sandoval ◽  
M Elena Lienqueo ◽  
Pablo Moisset ◽  
Marco Rito-Palomares ◽  
...  
Keyword(s):  
Affinity Chromatography ◽  
Rate Model ◽  
Heparin Affinity

A novel purification strategy for retrovirus gene therapy vectors using heparin affinity chromatography

2005 ◽  
Vol 90 (4) ◽  
pp. 391-404 ◽  
Author(s):  
Mar�a de las Mercedes Segura ◽  
Amine Kamen ◽  
Pierre Trudel ◽  
Alain Garnier
Keyword(s):  
Gene Therapy ◽  
Affinity Chromatography ◽  
Gene Therapy Vectors ◽  
Heparin Affinity

scholarly journals The Iron Regulatory Peptide Hepcidin Is Expressed in the Heart and Regulated by Hypoxia and Inflammation

Endocrinology ◽  
2007 ◽  
Vol 148 (6) ◽  
pp. 2663-2668 ◽  
Author(s):  
Uta Merle ◽  
Evelyn Fein ◽  
Sven Gustav Gehrke ◽  
Wolfgang Stremmel ◽  
Hasan Kulaksiz
Keyword(s):  
Regulatory Peptide

Effective Adjunctive Therapy by an Innate Defense Regulatory Peptide in a Preclinical Model of Severe Malaria

2012 ◽  
Vol 4 (135) ◽  
pp. 135ra64-135ra64 ◽  
Author(s):  
A. H. Achtman ◽  
S. Pilat ◽  
C. W. Law ◽  
D. J. Lynn ◽  
L. Janot ◽  
...  
Keyword(s):  
Severe Malaria ◽  
Adjunctive Therapy ◽  
Preclinical Model ◽  
Regulatory Peptide ◽  
Innate Defense

scholarly journals Iron absorption in hepcidin1 knockout mice

2011 ◽  
Vol 105 (11) ◽  
pp. 1583-1591 ◽  
Author(s):  
Patarabutr Masaratana ◽  
Abas H. Laftah ◽  
Gladys O. Latunde-Dada ◽  
Sophie Vaulont ◽  
Robert J. Simpson ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Iron Absorption ◽  
Fe Deficiency ◽  
Acute Effects ◽  
Regulatory Peptide ◽  
Fe Uptake

Hepcidin, the Fe-regulatory peptide, has been shown to inhibit Fe absorption and reticuloendothelial Fe recycling. The present study was conducted to explore the mechanism of in vivo Fe regulation through genetic disruption of hepcidin1 and acute effects of hepcidin treatment in hepcidin1 knockout (Hepc1− / − ) and heterozygous mice. Hepcidin1 disruption resulted in significantly increased intestinal Fe uptake. Hepcidin injection inhibited Fe absorption in both genotypes, but the effects were more evident in the knockout mice. Hepcidin administration was also associated with decreased membrane localisation of ferroportin in the duodenum, liver and, most significantly, in the spleen of Hepc1− / −  mice. Hypoferraemia was induced in heterozygous mice by hepcidin treatment, but not in Hepc1− / −  mice, 4 h after injection. Interestingly, Fe absorption and serum Fe levels in Hepc1− / −  and heterozygous mice fed a low-Fe diet were not affected by hepcidin injection. The present study demonstrates that hepcidin deficiency causes increased Fe absorption. The effects of hepcidin were abolished by dietary Fe deficiency, indicating that the response to hepcidin may be influenced by dietary Fe level or Fe status.

scholarly journals Peptidomic Identification and Biological Validation of Neuroendocrine Regulatory Peptide-1 and -2

2007 ◽  
Vol 282 (36) ◽  
pp. 26354-26360 ◽  
Author(s):  
Hideki Yamaguchi ◽  
Kazuki Sasaki ◽  
Yoshinori Satomi ◽  
Takuya Shimbara ◽  
Haruaki Kageyama ◽  
...  
Keyword(s):  
Regulatory Peptide ◽  
Biological Validation
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