Urinary Tract Infections in Infants and Children

2017 ◽  
pp. 231-246
Author(s):  
Marcello Napolitano ◽  
Anna Ravelli
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Infants And Children ◽  
Tract Infections ◽  
In Infants And Children

scholarly journals The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Panagiota Karananou ◽  
Despoina Tramma ◽  
Socrates Katafigiotis ◽  
Anastasia Alataki ◽  
Alexandros Lambropoulos ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Bacterial Infections ◽  
Pediatric Population ◽  
Infants And Children ◽  
Healthy Children ◽  
Healthy Infants ◽  
Tract Infections ◽  
In Infants And Children

Urinary tract infections are one of the most common and serious bacterial infections in a pediatric population. So far, they have mainly been related to age, gender, ethnicity, socioeconomic level, and the presence of underlying anatomical or functional, congenital, or acquired abnormalities. Recently, both innate and adaptive immunities and their interaction in the pathogenesis and the development of UTIs have been studied. The aim of this study was to assess the role and the effect of the two most frequent polymorphisms of TLR4 Asp299Gly and Thr399Ile on the development of UTIs in infants and children of Greek origin. We studied 51 infants and children with at least one episode of acute urinary tract infection and 109 healthy infants and children. We found that 27.5% of patients and 8.26% of healthy children carried the heterozygote genotype for TLR4 Asp299Gly. TLR4 Thr399Ile polymorphism was found to be higher in healthy children and lower in the patient group. No homozygosity for both studied polymorphisms was detected in our patients. In the group of healthy children, a homozygote genotype for TLR4 Asp299Gly (G/G) as well as for TLR4 Thr399Ile (T/T) was showed (1.84% and 0.92 respectively). These results indicate the role of TLR4 polymorphism as a genetic risk for the development of UTIs in infants and children of Greek origin.

Urinary Tract Infections in Infants and Children

1964 ◽  
Vol 91 (6) ◽  
pp. 623-638 ◽  
Author(s):  
Harry M. Spence ◽  
John J. Murphy ◽  
John H. Mcgovern ◽  
W. Hardy Hendren ◽  
Charles V. Pryles
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Infants And Children ◽  
Tract Infections ◽  
In Infants And Children

Undiscovered Urinary Tract Infections

PEDIATRICS ◽  
1967 ◽  
Vol 39 (6) ◽  
pp. 946-947
Author(s):  
MELVYN H. WOLK
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Signs And Symptoms ◽  
Infants And Children ◽  
Tract Infections ◽  
In Infants And Children

The occurrence of urinary tract infections in children has become an increasing problem. Pediatricians, especially those experiencing the "unhappy pediatric syndrome," should delight in investigating the manifold signs and symptoms with which these children may present. We have been taught that urologic symptoms, such as dysuria and frequency, may indicate an underlying urinary tract infection. However we must look further, for signs rather than symptoms in infants and children, for they may not be the best historians.

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