Role of Adenosine Receptors in Clinical Biophysics Based on Pulsed Electromagnetic Fields

2018 ◽  
pp. 557-580
Author(s):  
Katia Varani ◽  
Fabrizio Vincenzi ◽  
Matteo Cadossi ◽  
Stefania Setti ◽  
Pier Andrea Borea ◽  
...  
2020 ◽  
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pp. 285-293
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Giada Lullini ◽  
Eugenio Cammisa ◽  
Stefania Setti ◽  
Iacopo Sassoli ◽  
Stefano Zaffagnini ◽  
...  

PLoS ONE ◽  
2012 ◽  
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pp. e39317 ◽  
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Martina Targa ◽  
Carmen Corciulo ◽  
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Stefania Merighi ◽  
...  

Bone ◽  
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Da Jing ◽  
Guanghao Shen ◽  
Jinghui Huang ◽  
Kangning Xie ◽  
Jing Cai ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Katia Varani ◽  
Fabrizio Vincenzi ◽  
Annalisa Ravani ◽  
Silvia Pasquini ◽  
Stefania Merighi ◽  
...  

Several studies explored the biological effects of low frequency low energy pulsed electromagnetic fields (PEMFs) on human body reporting different functional changes. Much research activity has focused on the mechanisms of interaction between PEMFs and membrane receptors such as the involvement of adenosine receptors (ARs). In particular, PEMF exposure mediates a significant upregulation ofA2Aand A3ARs expressed in various cells or tissues involving a reduction in most of the proinflammatory cytokines. Of particular interest is the observation that PEMFs, acting as modulators of adenosine, are able to increase the functionality of the endogenous agonist. By reviewing the scientific literature on joint cells, a double role for PEMFs could be hypothesized in vitro by stimulating cell proliferation, colonization of the scaffold, and production of tissue matrix. Another effect could be obtained in vivo after surgical implantation of the construct by favoring the anabolic activities of the implanted cells and surrounding tissues and protecting the construct from the catabolic effects of the inflammatory status. Moreover, a protective involvement of PEMFs on hypoxia damage in neuron-like cells and an anti-inflammatory effect in microglial cells have suggested the hypothesis of a positive impact of this noninvasive biophysical stimulus.


PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
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Fabrizio Vincenzi ◽  
Paola De Luca ◽  
Enrico Ragni ◽  
...  

2016 ◽  
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Eugenio Grosso ◽  
Bruno Corrado ◽  
...  

2017 ◽  
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pp. 956-964 ◽  
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Mengyao Liu ◽  
Carlin Lee ◽  
Dominique Laron ◽  
Nianli Zhang ◽  
Erik I. Waldorff ◽  
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