Successful application of pulsed electromagnetic fields in a patient with post-COVID-19 fatigue: a case report

Summary Background Post-COVID-19 fatigue is a frequent symptom in COVID-19 survivors, which substantially limits patients to achieve full recovery and potentially restrains return to work. The previous literature has not yet reported the use of pulsed electromagnetic fields in this indication. Methods Over the course of 5 weeks, 10 sessions of pulsed electromagnetic field treatment with a high magnetic flux density were applied to a patient suffering from post-COVID-19 fatigue syndrome. Fatigue, work ability, quality of life as well as anxiety, depression, stress level, and resilience were evaluated using validated patient-reported outcome measures. Results Fatigue, work ability, quality of life, and psychological well-being improved clearly over the course of the treatment and showed stable results 6 weeks later. Conclusion The use of pulsed electromagnetic field therapy with a device that allows sufficient penetration of the body tissue might be a promising physical modality to manage post-COVID-19 fatigue syndrome, which could reduce clinical and economic health consequences. Clinical sham-controlled studies are needed to evaluate the effect of pulsed electromagnetic fields in this indication.

On the Issues of Spatial Modeling of Non-Standard Profiles by the Example of Electromagnetic Emission Measurement Data

This paper examines the possibility of the spatial modelling of the Earth’s natural pulsed-electromagnetic-field measured values, which form a closed profile without the data inside. This geophysical method allows us to map active tectonic movement which breaches the integrity of pipes. During the experiment, 4.5 km of profiles were measured in the Admiralteysky district of St. Petersburg, Russia. Regular electromotive force (EMF) values and anomalous EMF values were obtained, ranging from 0 to 900 µV and above 900 µV, respectively. The anomalous values are associated with tectonic faults in the bedrock. The data obtained are characterized by complex spatial anisotropy associated with the development of two groups of tectonic faults of different orientations. The authors have considered the problems of the spatial modeling of the data obtained. The main problems, the solutions to which should allow the obtaining of adequate models, have been identified. Based on the analysis of the measurement results, geological features of the studied areas, as well as variography, the following possible solutions were proposed: changing the measurement technique; dividing the data array according to the main directions of anisotropy; the need to introduce additional correction coefficients. The problem revealed in this article requires further research on the basis of the obtained results, which will reduce the cost and timing of such studies, and, as a result, give an opportunity to take into account active tectonic disturbances during the construction and scheduled maintenance of underground utilities, which is especially important within the framework of the concept of sustainable development.

WOUND HEALING IN HUMANS BY OPTIMIZATION OF LOW FREQUENCY SIGNAL FOR PULSED ELECTROMAGNETIC FIELD THERAPY

A wound, in clinical terms, is any tissue injury that causes skin rupture which penetrates epidermis and dermis layers leading to uncovering of underneath tissues or organs. Wounds can be superficial or deep, acute or chronic, with minor to serious implications depending on the source, extent, and location. Pulsed Electromagnetic Fields (PEMF) may have varying effects depending on the type of target tissue. Triggering a biological event requires a specific signal to be applied. The effectiveness of a PEMF device is mostly determined by the waveforms utilized in conjunction with the pulsing frequency. Choosing the right PEMF signal is a crucial step in developing a device that can address the challenges associated with chronic wound healing and speed up the healing process. Therefore, the optimization of the signal generator unit in the PEMF system for wound healing applications is a necessity before starting the further process. Hence, the present work of optimization of the PEMF system was carried out by selecting an optimal signal on the signal generator which produces a significant quantity of current in the particular tissue site to provide improved wound healing results. A total of 120 signal generator designs were simulated and optimized to six signal generators having frequencies of 10Hz, 20Hz, 30Hz, 40Hz, 50Hz, and 100Hz and duty cycle 25%. For both groups, the average frequency and duty cycle were calculated and tested using independent samples t-test to see if there were any differences between them. No statistically significant difference was found for frequency (p=0.9977) and duty cycle (p=0.5090). Because of the necessity of the right PEMF signal selection for every trial to be successful, this work will act as a gateway for selecting, understanding,` and considering the proper signal which could initiate the respective biological effect and accelerate the wound healing process.

Randomized, Placebo-Controlled Prospective Clinical Trial Evaluating the Efficacy of the Assisi Anti-anxiety Device (Calmer Canine) for the Treatment of Canine Separation Anxiety

Introduction: Separation anxiety (SA) is among the most common canine behavior disorders and affects quality-of-life for dogs and their owners. Dogs with SA show signs of anxiety during absence or perceived absence of their owners. While psychoactive medications are often helpful for treating SA, dog and human factors may limit their utility. This study explored the efficacy of a pulsed electromagnetic field (PEMF) device for treatment of canine SA.Materials and Methods: In this double-blind randomized placebo-controlled study, a screening questionnaire and baseline video confirmed the diagnosis of SA. Owners treated their dog with the device twice daily for 6 weeks, completed weekly questionnaires, and noted adverse events. Videos were taken of the dog while alone at weeks 4 and 6. Behaviors were coded and categorized as negative and positive. Questionnaire and video data at weeks 4 and 6 were compared to baseline.Results: Forty client-owned dogs with moderate to severe SA completed the study. There were no differences between groups for age, weight, or sex. In owner questionnaires, no difference in behavior or overall score was found between the active and sham groups (p > 0.05). Videos of the active group compared to the sham group showed significant reduction in negative behaviors by week 6 (p = 0.036) and higher percentage of success at week 4 (Z = 2.83, p = 0.005), at week 6 (Z = 1.65, p = 0.098), and across the full study (Z = 1.99, p = 0.047). Adverse events were reported in eight dogs (6 active, 2 sham); all resolved and were unlikely to be related to treatment.Discussion: This study supports the efficacy and safety of this PEMF device for treatment of SA in dogs. Questionnaire results may not be sensitive enough to detect subtle negative behavioral states compared to video, and may not capture other owner observed behavioral changes. A caregiver placebo effect may account for some improvement seen in both groups. Video data appear better for diagnosis and monitoring dog's behavior when left alone. Future studies should assess PEMF's impact on other anxieties or combination of anxiety disorders in dogs.

Effect of Pulsed Electro-Magnetic Field (PEMF) Therapy and Conventional Physiotherapy on Lipid Profile- A Randomised Control Trial

Introduction: The varying levels of lipids in the blood is defined as lipid profile, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides are most commonly reported. Pulsed Electromagnetic field therapy, is a therapy involves powerful pulsed energy waves passing through injured and damaged area of body of patients. Waves of pulsed electromagnetic field are painless and quick to pass through the damaged cells in the damaged region, increasing the oxygen pressure activating and regenerating cells. Methodology: A Total of 40 subjects will be included in the study. Divided in two groups 20 in group 1 and 20 in group 2.Group 1 will receive Pulsed electromagnetic field therapy (PEMF) with aerobic and resistance exercises while Group 2 will receive aerobic and resistance training exercises as conventional physiotherapy technique. Discussion: 13 meta-analyses were categorized by Pedersen and Saltin, they have reported lipid profile involvement following exercise. They have described that exercise have a positive effect on the pathogenesis, physical fitness of individuals with dyslipidaemia. Effect of exercise profile on lipid have been stated in few studies. This study will focus on studying the impact of pulsed electromagnetic field therapy on lipid profile. Conclusion: Conclusion will be drawn based on the outcome measures of the study and the statistical analysis.

Effect of external mechanical stimuli on human bone: a narrative review

Bone is a living composite material that has the capacity to adapt and respond to both internal and external stimuli. This capacity allows bone to adapt its structure to habitual loads and repair microdamage. Although human bone evolved to adapt to normal physiologic loading (for example from gravitational and muscle forces), these same biological pathways can potentially be activated through other types of external stimuli such as pulsed electromagnetic fields, mechanical vibration, and others. This review summarizes what is currently known about how human bone adapts to various types of external stimuli. We highlight how studies on sports-specific athletes and other exercise interventions have clarified the role of mechanical loading on bone structure. We also discuss clinical scenarios, such as spinal cord injury, where mechanical loading is drastically reduced, leading to rapid bone loss and permanent alterations to bone structure. Finally, we highlight areas of emerging research and unmet clinical need.

The Impact of Fast-Rise-Time Electromagnetic Field and Pressure on the Aggregation of Peroxidase upon Its Adsorption onto Mica

Our present study concerns the influence of the picosecond rise-time-pulsed electromagnetic field, and the impact of nanosecond pulsed pressure on the aggregation state of horseradish peroxidase (HRP) as a model enzyme. The influence of a 640 kV/m pulsed electromagnetic field with a pulse rise-time of ~200 ps on the activity and aggregation state of an enzyme is studied by the single-molecule atomic force microscopy (AFM) method. The influence of such a field is shown to lead to aggregation of the protein and to a decrease in its enzymatic activity. Moreover, the effect of a shock wave with a pressure front rise-time of 80 ns on the increase in the HRP aggregation is demonstrated. The results obtained herein can be of use in modeling the impact of electromagnetic and pressure pulses on enzymes and on whole living organisms. Our results are also important for taking into account the effect of pulsed fields on the body in the development of drugs, therapeutic procedures, and novel highly sensitive medical diagnosticums.

Mutual influence of currents in plane inductor system with solenoid between two massive conductors

Introduction. Inductor systems, as tools for metal processing, widely used in industrial technologies using the energy of powerful pulsed electromagnetic fields. Problem. A common disadvantage of the known works on the creation of tools for magnetic-pulse impact on conductive objects has the use of physical and mathematical models, in which the exciting currents do not depend on the ongoing electromagnetic processes. Such the assumption, have distorts the picture of the real energy in the working area of the inductor system. Goal. To obtain design ratios and numerical estimates of the mutual influence of exciting and induced currents of a flat inductor system with a circular solenoid located between massive well-conducting objects, moreover to carry out a theoretical analysis of electromagnetic processes in this system. Methodology. Have applied integrating Maxwell’s equations using the Laplace and Fourier-Bessel integral transformations in the approximation of the ideal conductivity of the metal objects to be processed. Results. The calculated relations for the theoretical analysis of electromagnetic processes have obtained in the high-frequency approximation. It shown that the inductance of the studied system decreases as the objects being processed approach the solenoid and increases as they move away from it. It found that for the invariability of the power indicators, of the proposed tool, a corresponding correction of the amplitude (on average up to 20 times) of the exciting current has necessary in the solenoid winding. Originality. For the first time, the tool design with a circular solenoid located between the massive metal objects has proposed for flat magnetic-pulse stamping. As a result of the theoretical analysis, the influence of electromagnetic processes on the currents flowing in the system has confirmed. Practical significance. The use of the results obtained will allow to increase the efficiency of the tool of magnetic-pulse technologies, and to reduce the energy costs for performing the specified production operations.