Reconstruction of Calvarial Bone Radionecrosis and Osteomyelitis

2022 ◽  
pp. 1-9
Author(s):  
Andreas Gravvanis ◽  
Despoina Kakagia
Keyword(s):  
Calvarial Bone

In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study

2018 ◽  
Vol 55 (4) ◽  
pp. 691-695
Author(s):  
Tudor Sorin Pop ◽  
Anca Maria Pop ◽  
Alina Dia Trambitas Miron ◽  
Klara Brinzaniuc ◽  
Simona Gurzu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Histological Study ◽  
Collagen Scaffold ◽  
Bone Defects ◽  
Collagen Scaffolds ◽  
In Vivo Evaluation ◽  
Calvarial Bone ◽  
Bone Apposition

The use of collagen scaffolds and stem cells for obtaining a tissue-engineering complex has been an important concept in promoting repair and regeneration of the bone tissue. Such units represent important steps in the development of an ideal scaffold-cell complex that would sustain new bone apposition. The aim of our study was to perform a histologic evaluation of the healing of critical-sized bone defects, using a biologic collagen scaffold with adipose-derived mesenchymal stem cells, in comparison to negative controls created in the adjacent bone. We used 16 Wistar rats and according to the study design 2 calvarial bone defects were created in each animal, one was filled with collagen seeded with adipose-derived stem cells and the other one was considered negative control. During the following month, at weekly intervals, the animals were euthanized and the specimens from bone defects were histologically evaluated. The results showed that these scaffolds were highly biocompatible as only moderate inflammation no rejection reactions were observed. Furthermore, the first signs of osseous healing appeared after two weeks accompanied by angiogenesis. Collagen scaffolds seeded with adipose-derived mesenchymal stem cells can be considered a promising treatment option in bone regeneration of large defects.

Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study

2019 ◽  
Vol 70 (6) ◽  
pp. 1983-1987
Author(s):  
Cristian Trambitas ◽  
Anca Maria Pop ◽  
Alina Dia Trambitas Miron ◽  
Dorin Constantin Dorobantu ◽  
Flaviu Tabaran ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bioactive Glass ◽  
Bone Repair ◽  
Bone Defects ◽  
Calvarial Bone ◽  
Specific Protocol ◽  
Repair Mechanisms ◽  
Male Wistar Rats

Large bone defects are a medical concern as these are often unable to heal spontaneously, based on the host bone repair mechanisms. In their treatment, bone tissue engineering techniques represent a promising approach by providing a guide for osseous regeneration. As bioactive glasses proved to have osteoconductive and osteoinductive properties, the aim of our study was to evaluate by histologic examination, the differences in the healing of critical-sized calvarial bone defects filled with bioactive glass combined with adipose-derived mesenchymal stem cells, compared to negative controls. We used 16 male Wistar rats subjected to a specific protocol based on which 2 calvarial bone defects were created in each animal, one was filled with Bon Alive S53P4 bioactive glass and adipose-derived stem cells and the other one was considered control. At intervals of one week during the following month, the animals were euthanized and the specimens from bone defects were histologically examined and compared. The results showed that this biomaterial was biocompatible and the first signs of osseous healing appeared in the third week. Bone Alive S53P4 bioactive glass could be an excellent bone substitute, reducing the need of bone grafts.

Autologous Calvarial Bone Remodeling Technique for Small to Medium-Sized Cranial Defects in Young Children: The “Switch-Cranioplasty” Technique

2021 ◽  
pp. 1-6
Author(s):  
Sonal Jain ◽  
Shelly Wang ◽  
Carolina Sandoval-Garcia ◽  
George M. Ibrahim ◽  
Walker L. Robinson ◽  
...  
Keyword(s):  
Bone Growth ◽  
Autologous Bone Graft ◽  
Dural Defect ◽  
Skull Defect ◽  
Calvarial Bone ◽  
Leptomeningeal Cyst ◽  
Case Presentation ◽  
Skull Defects ◽  
Calvarial Defects ◽  
Autologous Bone

<b><i>Introduction:</i></b> Reconstruction of cranial defects in children less than 2 years of age, particularly when there is an associated dural defect, is challenging due to the need to accommodate active skull growth, limited options for autologous bone graft and thin calvarial bones. We use a simple remodeling technique that exploits the normal dura’s inherent potential for new bone growth while covering the dural defect with adjacent skull. <b><i>Case Presentation:</i></b> We describe an alternating, two-piece craniotomy or “switch-cranioplasty technique” to repair an occipital meningocele. The two pieces of craniotomy bone flap created around the existing skull and dural defect are switched in the horizontal plane in order to cover the site of the defect and the abnormal dura of the meningocele closure. The area of the original skull defect is transposed laterally over the normal dura. The healing of the lateral skull defects is facilitated with autologous bone chips and dust and covered by periosteal flaps that stimulate spontaneous re-ossification. <b><i>Discussion:</i></b> The advantages of this technique are the use of autologous bone adjacent to the skull defect, incorporation of the autologous bone into the growing skull, an acceptable cosmetic and functional outcome in a simple manner. The indications can be extended to include small to medium-sized calvarial defects secondary to leptomeningeal cyst and trauma.

Suramin inhibits bone resorption and reduces osteoblast number in a neonatal mouse calvarial bone resorption assay.

Endocrinology ◽  
1992 ◽  
Vol 131 (5) ◽  
pp. 2263-2270 ◽  
Author(s):  
M M Walther ◽  
P J Kragel ◽  
E Trahan ◽  
D Venzon ◽  
H C Blair ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Neonatal Mouse ◽  
Calvarial Bone

Adenine nucleotide levels and adenosine metabolism in cultured calvarial bone

1984 ◽  
Vol 120 (4) ◽  
pp. 551-555 ◽  
Author(s):  
BERTIL B. FREDHOLM ◽  
ULF LERNER
Keyword(s):  
Adenine Nucleotide ◽  
Calvarial Bone

scholarly journals Erratum to: Osteoconduction capacity of human deciduous and permanent teeth ash in a rat calvarial bone defect model

2015 ◽  
Vol 16 (4) ◽  
pp. 651-651
Author(s):  
Boram Min ◽  
Je Seon Song ◽  
Seong-Oh Kim ◽  
Kwang-Mahn Kim ◽  
Won Se Park ◽  
...  
Keyword(s):  
Bone Defect ◽  
Permanent Teeth ◽  
Defect Model ◽  
Calvarial Bone ◽  
Calvarial Bone Defect

Pattern of healing of calvarial bone in the rat following application of the erbium-YAG laser

1997 ◽  
Vol 21 (3) ◽  
pp. 255-261 ◽  
Author(s):  
Mansour A. El Montaser ◽  
Hugh Devlin ◽  
Philip Sloan ◽  
Mark R. Dickinson
Keyword(s):  
Calvarial Bone ◽  
Yag Laser

Split Calvarial Bone Graft in Cranio-orbital Sphenoid Wing Reconstruction

1996 ◽  
Vol 7 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Frank A. Papay ◽  
James E. Zins ◽  
Joseph F. Hahn
Keyword(s):  
Bone Graft ◽  
Calvarial Bone
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