3D magnetic nanocomposite scaffolds enhanced the osteogenic capacities of rat bone mesenchymal stem cells in vitro and in a rat calvarial bone defect model by promoting cell adhesion

2021 ◽  
Author(s):  
Liping Han ◽  
Yu Guo ◽  
Lu Jia ◽  
Qian Zhang ◽  
Liuxu Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Adhesion ◽  
Defect Model ◽  
Calvarial Bone ◽  
Bone Mesenchymal Stem Cells ◽  
Calvarial Bone Defect ◽  
Nanocomposite Scaffolds ◽  
Rat Bone

Repair of Calvarial Bone Defect Using Jarid1a-Knockdown Bone Mesenchymal Stem Cells in Rats

2018 ◽  
Vol 24 (9-10) ◽  
pp. 711-718 ◽  
Author(s):  
Yuan Deng ◽  
Tao Guo ◽  
Jipeng Li ◽  
Li Guo ◽  
Ping Gu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Defect ◽  
Calvarial Bone ◽  
Bone Mesenchymal Stem Cells ◽  
Calvarial Bone Defect

scholarly journals Nanoscale Modification of Titanium Implants Improves Behaviors of Bone Mesenchymal Stem Cells and Osteogenesis In Vivo

2022 ◽  
Vol 2022 ◽  
pp. 1-13
Author(s):  
Huangdi Li ◽  
Jinghui Huang ◽  
Yanpeng Wang ◽  
Ziyuan Chen ◽  
Xing Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Surface Characteristics ◽  
Titanium Implants ◽  
Bone Mesenchymal Stem Cells ◽  
H2o2 Treatment ◽  
Cell Behaviors ◽  
Rat Bone

The surficial micro/nanotopography and physiochemical properties of titanium implants are essential for osteogenesis. However, these surface characters’ influence on stem cell behaviors and osteogenesis is still not fully understood. In this study, titanium implants with different surface roughness, nanostructure, and wettability were fabricated by further nanoscale modification of sandblasted and acid-etched titanium (SLA: sandblasted and acid-etched) by H2O2 treatment (hSLAs: H2O2 treated SLA). The rat bone mesenchymal stem cells (rBMSCs: rat bone mesenchymal stem cells) are cultured on SLA and hSLA surfaces, and the cell behaviors of attachment, spreading, proliferation, and osteogenic differentiation are further analyzed. Measurements of surface characteristics show hSLA surface is equipped with nanoscale pores on microcavities and appeared to be hydrophilic. In vitro cell studies demonstrated that the hSLA titanium significantly enhances cell response to attachment, spreading, and proliferation. The hSLAs with proper degree of H2O2 etching (h1SLA: treating SLA with H2O2 for 1 hour) harvest the best improvement of differentiation of rBMSCs. Finally, the osteogenesis in beagle dogs was tested, and the h1SLA implants perform much better bone formation than SLA implants. These results indicate that the nanoscale modification of SLA titanium surface endowing nanostructures, roughness, and wettability could significantly improve the behaviors of bone mesenchymal stem cells and osteogenesis on the scaffold surface. These nanoscale modified SLA titanium scaffolds, fabricated in our study with enhanced cell affinity and osteogenesis, had great potential for implant dentistry.

Nanodiamonds of Different Surface Chemistry Influence the Toxicity and Differentiation of Rat Bone Mesenchymal Stem Cells In Vitro

2019 ◽  
Vol 19 (9) ◽  
pp. 5426-5434 ◽  
Author(s):  
Yixian Zhang ◽  
Wenjing Zhang ◽  
Yuri Fedutik ◽  
Zhengwei Mao ◽  
Changyou Gao
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Surface Chemistry ◽  
Bone Mesenchymal Stem Cells ◽  
Rat Bone

scholarly journals AB114. Myogenic differentiation of rat bone mesenchymal stem cells in vitro

2016 ◽  
Vol 5 (S1) ◽  
pp. AB114-AB114
Author(s):  
Heng-Jun Xiao ◽  
Wei-Xin Yan ◽  
Jun Chen ◽  
Xin Gao ◽  
Li Zhuan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Myogenic Differentiation ◽  
Bone Mesenchymal Stem Cells ◽  
Rat Bone

Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis

2018 ◽  
Vol 18 ◽  
Author(s):  
Chaitra Venugopal ◽  
Christopher Shamir ◽  
Sivapriya Senthilkumar ◽  
Janitri Venkatachala Babu ◽  
Peedikayil Kurien Sonu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Neuroprotective Effects ◽  
Marrow Mesenchymal Stem Cells ◽  
Vitro Analysis ◽  
In Vitro Analysis ◽  
Rat Bone

MicroRNA-21 promotes bone mesenchymal stem cells migration in vitro by activating PI3K/Akt/MMPs pathway

2017 ◽  
Vol 46 ◽  
pp. 156-162 ◽  
Author(s):  
Chen Lv ◽  
Shengwu Yang ◽  
Xin Chen ◽  
Xiongbai Zhu ◽  
Wenjun Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Mesenchymal Stem Cells

scholarly journals Tenuigenin promotes the osteogenic differentiation of bone mesenchymal stem cells in vitro and in vivo

2016 ◽  
Vol 367 (2) ◽  
pp. 257-267 ◽  
Author(s):  
Hua-ji Jiang ◽  
Xing-gui Tian ◽  
Shou-bin Huang ◽  
Guo-rong Chen ◽  
Min-jun Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Bone Mesenchymal Stem Cells

Osteogenic differentiation of rat bone mesenchymal stem cells modulated by MiR-186 via SIRT6

Life Sciences ◽  
2020 ◽  
Vol 253 ◽  
pp. 117660 ◽  
Author(s):  
Jijie Xiao ◽  
Sisi Qin ◽  
Wei Li ◽  
Lin Yao ◽  
Panhui Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Bone Mesenchymal Stem Cells ◽  
Rat Bone
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