Anticholinergic Side Effects

AbstractAll deaths occurring in the in-patient population of the Central Mental Hospital during the period 1963 to 1987 inclusive were examined. The death rate during the total period was 11.7 per 1,000 admissions. The suicide rate during the total period was 3.9 per 1,000 admissions – there had been no suicides during the most recent five year period. Although the admission rate has been rising since the mid-1970s, the death rate over the last fifteen years has remained stable.Many of the deaths prior to 1970 were in elderly long stay patients who died from natural causes. Five deaths in young patients are described separately – in two of these anticholinergic side effects of medication may have contibuted to the deaths. Seven suicides occcuring during the study period are described separately – four of these occurred in the months soon after admission.

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A SHORT-TERM, MULTICENTER, RANDOMIZED DOUBLE-BLIND DOSE TITRATION STUDY OF THE EFFICACY AND ANTICHOLINERGIC SIDE EFFECTS OF TRANSDERMAL COMPARED TO IMMEDIATE RELEASE ORAL OXYBUTYNIN TREATMENT OF PATIENTS WITH URGE URINARY INCONTINENCE

The Journal of Urology ◽

10.1016/s0022-5347(05)66095-8 ◽

2001 ◽

Vol 166 (1) ◽

pp. 140-145 ◽

Cited By ~ 148

Author(s):

G.W. DAVILA ◽

C.A. DAUGHERTY ◽

S.W. SANDERS ◽

Keyword(s):

Urinary Incontinence ◽

Side Effects ◽

Urge Urinary Incontinence ◽

Immediate Release ◽

Dose Titration ◽

Short Term ◽

Double Blind ◽

Anticholinergic Side Effects ◽

Titration Study

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Sudden Infant Death Syndrome and Phenothiazines

PEDIATRICS ◽

10.1542/peds.71.6.986 ◽

1983 ◽

Vol 71 (6) ◽

pp. 986-987

Author(s):

A. N. STANTON

Keyword(s):

Side Effects ◽

Sudden Infant Death Syndrome ◽

Temperature Rise ◽

Temperature Regulation ◽

Infant Death ◽

Sudden Infant Death ◽

Sudden Infant ◽

Standard Dosage ◽

The Relationship ◽

Anticholinergic Side Effects

To the Editor.— Kahn and Blum1 discuss the relationship between phenothiazines and the sudden infant death syndrome (SIDS) but do not mention the potentially important anticholinergic side effects of this group of drugs. Phenothiazines impair temperature regulation, including the ability to sweat, and are implicated in many reports of heatstroke2,3 and hypothermia. Any temperature rise tends to occur early in treatment4 and may bee provoked by standard dosage.5 Studies in mice given a single 1-mg/kg dose of chlorpromazine show that younger animals become hyperthermic, whereas older ones becomes hypothermic.6

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