Polygala senega

2007 ◽  
pp. 436-436
Author(s):  
Marina Bährle-Rapp
Keyword(s):  
Polygala Senega

Adjuvant activities of saponins from the root of Polygala senega L.This article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products.

2007 ◽  
Vol 85 (11) ◽  
pp. 1184-1194 ◽  
Author(s):  
Georgios S. Katselis ◽  
Alberto Estrada ◽  
Dennis K.J. Gorecki ◽  
Branka Barl
Keyword(s):  
Haemolytic Activity ◽  
Triterpenoid Saponin ◽  
Natural Health Products ◽  
Vaccine Adjuvants ◽  
Natural Health ◽  
Canadian Prairies ◽  
Quillaja Saponaria ◽  
Polygala Senega ◽  
Health Products

Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a plant indigenous to the Canadian prairies, were evaluated for their immunological activity in mouse models. The specific antibody responses of the IgG2a subclass increased significantly when isolated P. senega saponins were used as adjuvants in the immunization of mice with OVA antigen. In addition, increased IL-2 levels were observed in spleen cell cultures from P. senega saponin-immunized mice after in vitro secondary antigen stimulation. The saponins were tested for their toxicity in mice by using a haemolytic activity assay and found to be less toxic than Quillaja saponaria saponins that have long been used as adjuvants in vaccine formulations. This study has shown the potential of P. senega saponins to be considered as a natural source of vaccine adjuvants with biological activity equivalent to the current commercially available saponin adjuvants.

scholarly journals THE SAPOGENINS OF POLYGALA SENEGA

1937 ◽  
Vol 119 (1) ◽  
pp. 155-170
Author(s):  
Walter A. Jacobs ◽  
Otto Isler
Keyword(s):  
Polygala Senega

scholarly journals Studies on Oligosaccharides. XIII. Oligosaccharides in Polygala senega and Structures of Glycosyl-1, 5-anhydro-D-glucitols

1974 ◽  
Vol 94 (8) ◽  
pp. 998-1003 ◽  
Author(s):  
KIYOSHI TAKIURA ◽  
MINORU YAMAMOTO ◽  
HARUMI MURATA ◽  
HITOSHI TAKAI ◽  
SUSUMU HONDA ◽  
...  
Keyword(s):  
Polygala Senega

scholarly journals Senegoses F-I, Oligosaccharide Multi-Esters from the Roots of Polygala senega var. Iatifolia TORR. et GRAY.

1993 ◽  
Vol 41 (12) ◽  
pp. 2125-2128 ◽  
Author(s):  
Hideki SAITOH ◽  
Toshio MIYASE ◽  
Akira UENO
Keyword(s):  
Polygala Senega
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