Background-Free Apertureless Near-Field Optical Imaging

Author(s):  
Pietro Giuseppe Gucciardi ◽  
Guillaume Bachelier ◽  
Stephan J. Stranick ◽  
Maria Allegrini
Keyword(s):  
2004 ◽  
Vol 43 (19) ◽  
pp. 3829 ◽  
Author(s):  
Lionel Aigouy ◽  
Yannick De Wilde ◽  
Michel Mortier ◽  
Jacques Giérak ◽  
Eric Bourhis

2010 ◽  
Author(s):  
Hsing-Ying Lin ◽  
Chen-Han Huang ◽  
Chih-Han Chang ◽  
Yun-Chiang Lan ◽  
Hsiang-Chen Chui

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Guangzhong Ma ◽  
Zijian Wan ◽  
Yunze Yang ◽  
Pengfei Zhang ◽  
Shaopeng Wang ◽  
...  

Abstract Detection and identification of proteins are typically achieved by analyzing protein size, charge, mobility and binding to antibodies, which are critical for biomedical research and disease diagnosis and treatment. Despite the importance, measuring these quantities with one technology and at the single-molecule level has not been possible. Here we tether a protein to a surface with a flexible polymer, drive it into oscillation with an electric field, and image the oscillation with a near field optical imaging method, from which we determine the size, charge, and mobility of the protein. We also measure antibody binding and conformation changes in the protein. The work demonstrates a capability for comprehensive protein analysis and precision protein biomarker detection at the single molecule level.


2015 ◽  
Vol 13 (1) ◽  
pp. 2 ◽  
Author(s):  
Laura Andolfi ◽  
Elisa Trevisan ◽  
Barbara Troian ◽  
Stefano Prato ◽  
Rita Boscolo ◽  
...  

2006 ◽  
Vol 110 (27) ◽  
pp. 8297-8303 ◽  
Author(s):  
Yuval Ebenstein ◽  
Eyal Yoskovitz ◽  
Ronny Costi ◽  
Assaf Aharoni ◽  
Uri Banin

2014 ◽  
Vol 53 (3) ◽  
pp. 030301 ◽  
Author(s):  
Masaru Sakai ◽  
Yuta Inose ◽  
Tomi Ohtsuki ◽  
Kazuhiro Ema ◽  
Katsumi Kishino ◽  
...  

1995 ◽  
Vol 66 (9) ◽  
pp. 1141-1143 ◽  
Author(s):  
M. W. J. Prins ◽  
R. H. M. Groeneveld ◽  
D. L. Abraham ◽  
H. van Kempen ◽  
H. W. van Kesteren

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