Leukemia and Leukemic Stem Cells

2004 ◽  
pp. 157-182 ◽  
Author(s):  
Catriona H. M. Jamieson ◽  
Emmanuelle Passegué ◽  
Irving L. Weissman
Keyword(s):  
Stem Cells ◽  
Leukemic Stem Cells

High Proportion of Leukemic Stem Cells at Diagnosis Is Correlated with Unfavorable Prognosis in Childhood Acute Myeloid Leukemia

2011 ◽  
Vol 28 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Kai-Erik Witte ◽  
Jörg Ahlers ◽  
Iris Schäfer ◽  
Maya André ◽  
Gunter Kerst ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemic Stem Cells ◽  
Childhood Acute Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lars Velten ◽  
Benjamin A. Story ◽  
Pablo Hernández-Malmierca ◽  
Simon Raffel ◽  
Daniel R. Leonce ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Single Cell ◽  
Lineage Tracing ◽  
Specific Gene ◽  
Leukemic Stem Cells ◽  
Hematopoietic Stem ◽  
Mutational Status

AbstractCancer stem cells drive disease progression and relapse in many types of cancer. Despite this, a thorough characterization of these cells remains elusive and with it the ability to eradicate cancer at its source. In acute myeloid leukemia (AML), leukemic stem cells (LSCs) underlie mortality but are difficult to isolate due to their low abundance and high similarity to healthy hematopoietic stem cells (HSCs). Here, we demonstrate that LSCs, HSCs, and pre-leukemic stem cells can be identified and molecularly profiled by combining single-cell transcriptomics with lineage tracing using both nuclear and mitochondrial somatic variants. While mutational status discriminates between healthy and cancerous cells, gene expression distinguishes stem cells and progenitor cell populations. Our approach enables the identification of LSC-specific gene expression programs and the characterization of differentiation blocks induced by leukemic mutations. Taken together, we demonstrate the power of single-cell multi-omic approaches in characterizing cancer stem cells.

Nanoparticle‐Mediated Delivery of Micheliolide Analogs to Eliminate Leukemic Stem Cells in the Bone Marrow

2021 ◽  
pp. 2100100
Author(s):  
Marian A. Ackun‐Farmmer ◽  
Hanan Alwaseem ◽  
Michele Counts ◽  
Andrew Bortz ◽  
Simone Giovani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Leukemic Stem Cells

O-10 Bmi-1 expression predicts the progression of leukemic stem cells and prognosis in myelodysplastic syndrome

2005 ◽  
Vol 29 ◽  
pp. S3-S4
Author(s):  
K. Mihara ◽  
N. Nakaju ◽  
S. Hidani ◽  
M. Chowdhury ◽  
A. Ihara ◽  
...  
Keyword(s):  
Stem Cells ◽  
Myelodysplastic Syndrome ◽  
Leukemic Stem Cells ◽  
O 10

scholarly journals Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RAR -positive leukemic stem cells

Haematologica ◽  
2007 ◽  
Vol 92 (3) ◽  
pp. 323-331 ◽  
Author(s):  
X. Zheng ◽  
A. Seshire ◽  
B. Ruster ◽  
G. Bug ◽  
T. Beissert ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Retinoic Acid ◽  
Leukemic Stem Cells ◽  
Trans Retinoic Acid ◽  
Cell Capacity ◽  
All Trans Retinoic Acid

scholarly journals LSK Derived LSK– Cells Have a High Apoptotic Rate Related to Survival Regulation of Hematopoietic and Leukemic Stem Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e38614 ◽  
Author(s):  
Cong Peng ◽  
Yaoyu Chen ◽  
Yi Shan ◽  
Haojian Zhang ◽  
Zhiru Guo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Leukemic Stem Cells
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