scholarly journals Synthetic Sequence Design for Signal Location Search

Author(s):  
Yaw-Ling Lin ◽  
Charles Ward ◽  
Steven Skiena
Algorithmica ◽  
2013 ◽  
Vol 67 (3) ◽  
pp. 368-383
Author(s):  
Yaw-Ling Lin ◽  
Charles Ward ◽  
Steven Skiena

2009 ◽  
Vol E92-B (6) ◽  
pp. 2308-2311 ◽  
Author(s):  
Fang YANG ◽  
Kewu PENG ◽  
Jun WANG ◽  
Jian SONG ◽  
Zhixing YANG

2019 ◽  
Author(s):  
Michael Oschmann ◽  
Linus Johansson Holm ◽  
Oscar Verho

Benzofurans are everywhere in nature and they have been extensively studied by medicinal chemists over the years because of their chemotherapeutic and physiological properties. Herein, we describe a strategy that can be used to access elaborate benzo-2-carboxamide derivatives, which involves a synthetic sequence of 8-aminoquinoline directed C–H arylations followed by transamidations. For the directed C–H arylations, Pd catalysis was used to install a wide range of aryl and heteroaryl substituents at the C3 position of the benzofuran scaffold in high efficiency. Directing group cleavage and further diversification of the C3-arylated benzofuran products were then achieved in a single synthetic operation through the utilization of a two-step transamidation protocol. By bocylating the 8-aminoquinoline amide moiety of these products, it proved possible to activate them towards aminolysis with different amine nucleophiles. Interestingly, this aminolysis reaction was found to proceed efficiently without the need of any additional catalyst or additive. Given the high efficiency and modularity of this synthetic strategy, it constitute a very attractive approach for generating structurally-diverse collections of benzofuran derivatives for small molecule screening.


Author(s):  
Ahmed Elhamy Mostafa ◽  
Vincent W.S. Wong ◽  
Yong Zhou ◽  
Robert Schober ◽  
Zhe Luo ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1466
Author(s):  
Ye Eun Kim ◽  
Hyunsung Cho ◽  
Yoo Jin Lim ◽  
Chorong Kim ◽  
Sang Hyup Lee

Studies on a one-pot synthesis of novel multisubstituted 1-alkoxyindoles 1 and their mechanistic investigations are presented. The synthesis of 1 was successfully achieved through consecutive four step reactions from substrates 2. The substrates 2, prepared through a two-step synthetic sequence, underwent three consecutive reactions of nitro reduction, intramolecular condensation, and nucleophilic 1,5-addition to provide the intermediates, 1-hydroxyindoles 8, which then were alkylated in situ with alkyl halide to afford the novel target products 1. We optimized the reaction conditions for 1 focusing on the alkylation step, along with the consideration of formation of intermediates 8. The optimized condition was SnCl2·2H2O (3.3 eq) and alcohols (R1OH, 2.0 eq) for 1–2 h at 40 °C and then, base (10 eq) and alkyl halides (R2Y, 2.0 eq) for 1–4 h at 25–50 °C. Notably, all four step reactions were performed in one-pot to give 1 in good to modest yields. Furthermore, the mechanistic aspects were also discussed regarding the reaction pathways and the formation of side products. The significance lies in development of efficient one-pot reactions and in generation of new 1-alkoxyindoles.


2019 ◽  
Vol 67 (18) ◽  
pp. 4683-4695 ◽  
Author(s):  
Linlong Wu ◽  
Daniel P. Palomar

2006 ◽  
Vol 10 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Die Hu ◽  
Luxi Yang ◽  
Yuhui Shi ◽  
Lianghua He

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