Pharmacology and Clinical Use of Sex Steroid Hormone Receptor Modulators

2012 ◽  
pp. 543-587 ◽  
Author(s):  
A. Cleve ◽  
K.-H. Fritzemeier ◽  
B. Haendler ◽  
N. Heinrich ◽  
C. Möller ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Steroid Hormone ◽  
Sex Steroid ◽  
Steroid Hormone Receptor ◽  
Clinical Use ◽  
Sex Steroid Hormone ◽  
Receptor Modulators

scholarly journals Molecular Cloning, Characterization, and Chromosome Mapping of Reptilian Estrogen Receptors

Endocrinology ◽  
2010 ◽  
Vol 151 (12) ◽  
pp. 5710-5720 ◽  
Author(s):  
Yoshinao Katsu ◽  
Kazumi Matsubara ◽  
Satomi Kohno ◽  
Yoichi Matsuda ◽  
Michihisa Toriba ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Hormone Receptor ◽  
Molecular Mechanisms ◽  
Steroid Hormone ◽  
Chromosome 1 ◽  
Sex Steroid ◽  
Steroid Hormone Receptor ◽  
Sex Steroid Hormone ◽  
Ligand Interactions ◽  
Rat Snake

In many vertebrates, steroid hormones are essential for ovarian differentiation during a critical developmental stage as well as promoting the growth and differentiation of the adult female reproductive system. Although studies have been extensively conducted in mammals and a few fish, amphibians, and bird species, the molecular mechanisms of sex steroid hormone (estrogens) action have been poorly examined in reptiles. Here, we evaluate hormone receptor and ligand interactions in two species of snake, the Okinawa habu (Protobothrops flavoviridis, Viperidae) and the Japanese four-striped rat snake (Elaphe quadrivirgata, Colubridae) after the isolation of cDNAs encoding estrogen receptor α (ESR1) and estrogen receptor β (ESR2). Using a transient transfection assay with mammalian cells, the transcriptional activity of reptilian (Okinawa habu, Japanese four-striped rat snake, American alligator, and Florida red-belly freshwater turtle) ESR1 and ESR2 was examined. All ESR proteins displayed estrogen-dependent activation of transcription via an estrogen-response element-containing promoter; however, the responsiveness to various estrogens was different. Further, we determined the chromosomal locations of the snake steroid hormone receptor genes. ESR1 and ESR2 genes were localized to the short and long arms of chromosome 1, respectively, whereas androgen receptor was localized to a pair of microchromosomes in the two snake species examined. These data provide basic tools that allow future studies examining receptor-ligand interactions and steroid endocrinology in snakes and also expands our knowledge of sex steroid hormone receptor evolution.

Histological and sex steroid hormone receptor changes in testes of immature, mature, and aged chickens

2008 ◽  
Vol 35 (4) ◽  
pp. 371-379 ◽  
Author(s):  
María Genoveva González-Morán ◽  
Christian Guerra-Araiza ◽  
María G. Campos ◽  
Ignacio Camacho-Arroyo
Keyword(s):  
Hormone Receptor ◽  
Steroid Hormone ◽  
Sex Steroid ◽  
Steroid Hormone Receptor ◽  
Sex Steroid Hormone

Sex steroid hormone receptor analysis in malignant melanoma

1982 ◽  
Vol 107 (s23) ◽  
pp. 54-59 ◽  
Author(s):  
EVA-MARIA KOKOSCHKA ◽  
JURGEN SPONA ◽  
ROBERT KNOBLER
Keyword(s):  
Malignant Melanoma ◽  
Hormone Receptor ◽  
Steroid Hormone ◽  
Sex Steroid ◽  
Steroid Hormone Receptor ◽  
Sex Steroid Hormone

scholarly journals Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity

2010 ◽  
Vol 3 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Marie E. Monaco ◽  
Chad J. Creighton ◽  
Peng Lee ◽  
Xuanyi Zou ◽  
Matthew K. Topham ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Steroid Hormone ◽  
Fatty Acyl ◽  
Sex Steroid ◽  
Steroid Hormone Receptor ◽  
Sex Steroid Hormone ◽  
Prostate Cancers ◽  
Long Chain ◽  
Receptor Negativity

scholarly journals Sex steroid hormone receptor expression in the vaginal wall in cervical cancer survivors after radiotherapy

2019 ◽  
Vol 58 (8) ◽  
pp. 1107-1115 ◽  
Author(s):  
Alexandra Hofsjö ◽  
Nina Bohm-Starke ◽  
Karin Bergmark ◽  
Britt Masironi ◽  
Lena Sahlin
Keyword(s):  
Cervical Cancer ◽  
Cancer Survivors ◽  
Hormone Receptor ◽  
Steroid Hormone ◽  
Vaginal Wall ◽  
Receptor Expression ◽  
Sex Steroid ◽  
Steroid Hormone Receptor ◽  
Sex Steroid Hormone ◽  
Hormone Receptor Expression
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