Serotonin-Expressing Cells from Different Microregions of the Embryonic Rat Rhombencephalon: Behaviour in Cell Culture and in Transplants to the Adult Spinal Cord

1989 ◽  
pp. 150-164 ◽  
Author(s):  
N. König ◽  
N. Rajaofetra ◽  
M. J. Drian ◽  
F. Favier ◽  
F. Sandillon ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Culture ◽  
Adult Spinal Cord

Atypical pilocytic astrocytoma of adult spinal cord: A case report

2018 ◽  
pp. 1-2
Keyword(s):  
Spinal Cord ◽  
Young Adults ◽  
Case Report ◽  
Pilocytic Astrocytoma ◽  
Treatment Protocol ◽  
Pilomyxoid Astrocytoma ◽  
Standardized Treatment ◽  
Children And Young Adults ◽  
Adult Spinal Cord

Pilomyxoid astrocytoma (PMA) is an atypical subtype of pilocytic astrocytoma (PA), which presents in children and young adults. The incidence of PMA is low, so there is no standardized treatment protocol for it. Here, we present a 62-year-old woman with recurrent PMA, which is important for the understanding and treatment of the disease.

scholarly journals PATH-23. ADULT SPINAL CORD ASTROBLASTOMA WITH EWSR1-BEND2 FUSION

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii429-iii429
Author(s):  
Takeyoshi Tsutsui ◽  
Yoshiki Arakawa ◽  
Yasuhide Makino ◽  
Hiroharu Kataoka ◽  
Sachiko Minamiguti ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Residual Tumor ◽  
Intramedullary Tumor ◽  
Partial Removal ◽  
Weighted Image ◽  
Eosinophilic Cytoplasm ◽  
S 100 ◽  
High Cellularity ◽  
Adult Spinal Cord

Abstract The most recurrent fusion of CNS high-grade neuroepithelial tumor with MN1alteration(HGNET-MN1) is MN1- BEN Domain Containing 2(BEND2) fusion. Recently, there was a report of a 3-month-old boy with spinal astroblastoma, classified as CNS HGNET-MN1 by DKFZ methylation classification but positive for EWSR1-BEND2 fusion(Yamasaki, 2019). Here, we report a 36-year old man with a spinal cord astroblastoma with EWSR1 alternation. The patient presented with back pain, gait disorder and dysesthesia in lower extremities and trunk was referred to our hospital. MRI showed intramedullary tumor in Th3-5 level, displaying low-intensity on T1 weighted image, high-intensity on T2 weighted image, and homogeneous gadolinium enhancement. Partial removal was performed with the laminectomy. The tumor extended to extramedullary and its boundary was unclear. Histological examinations showed the epithelium-like tumor cells with eosinophilic cytoplasm with high cellularity palisade, intracellar fibrosis, and mitosis. Immunohistochemical staining showed positive for Olig2, GFAP, EMA, SSTR2, S-100, but negative for p53, PgRAE1/AE3. The tumor was diagnosed as astroblastoma, and was classified as HGNET-MN1 by the DKFZ methylation classifier. However, the MN1 alternation was not detected by fluorescence in situ hybridization, instead EWSR1 and BEND2 alternations which suggested EWSR1-BEND2 fusion were detected. After radiation therapy of 54Gy/30fr with bevacizumab and temozolomide, the residual tumor reduced the size and his symptoms improved. This case provides evidence that EWSR1-BEND2 fusion is recurrent in HGNET-MN1 and, as previously reported, suggests the importance of BEND2 in this entity. These two cases suggested that it may be the BEND2 alteration that biologically defines the HGNET-MN1 subclass rather than MN1.

Muscle-conditioned media and cAMP promote survival and neurite outgrowth of adult spinal cord motor neurons

2009 ◽  
Vol 220 (2) ◽  
pp. 303-315 ◽  
Author(s):  
Jose V. Montoya G. ◽  
Jhon Jairo Sutachan ◽  
Wai Si Chan ◽  
Alexandra Sideris ◽  
Thomas J.J. Blanck ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neurite Outgrowth ◽  
Motor Neurons ◽  
Conditioned Media ◽  
Adult Spinal Cord

Expression of neurotrophins in the adult spinal cord in vivo

1999 ◽  
Vol 56 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Cheryl F. Dreyfus ◽  
Xudong Dai ◽  
Lauren D. Lercher ◽  
Bernard R. Racey ◽  
Wilma J. Friedman ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Adult Spinal Cord
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