Faculty Opinions recommendation of Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain.

2012 ◽  
Author(s):  
Richard Traub
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Gabaergic Neuron ◽  
Adult Spinal Cord

scholarly journals Forebrain GABAergic Neuron Precursors Integrate into Adult Spinal Cord and Reduce Injury-Induced Neuropathic Pain

Neuron ◽  
2012 ◽  
Vol 74 (4) ◽  
pp. 663-675 ◽  
Author(s):  
João M. Bráz ◽  
Reza Sharif-Naeini ◽  
Daniel Vogt ◽  
Arnold Kriegstein ◽  
Arturo Alvarez-Buylla ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Gabaergic Neuron ◽  
Adult Spinal Cord

Hyperbaric oxygenation alleviates chronic constriction injury (CCI)-induced neuropathic pain and inhibits GABAergic neuron apoptosis in the spinal cord

2017 ◽  
Vol 17 (1) ◽  
pp. 330-338 ◽  
Author(s):  
Huiqun Fu ◽  
Fenghua Li ◽  
Sebastian Thomas ◽  
Zhongjin Yang
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Cytochrome C ◽  
Mechanical Allodynia ◽  
Caspase 3 ◽  
Chronic Constriction Injury ◽  
Gabaergic Neurons ◽  
Gabaergic Neuron ◽  
Apoptotic Pathways ◽  
Neuron Apoptosis

AbstractBackground and aimsDysfunction of GABAergic inhibitory controls contributes to the development of neuropathic pain. We examined our hypotheses that (1) chronic constriction injury (CCI)-induced neuropathic pain is associated with increased spinal GABAergic neuron apoptosis, and (2) hyperbaric oxygen therapy (HBO) alleviates CCI-induced neuropathic pain by inhibiting GABAergic neuron apoptosis.MethodsMale rats were randomized into 3 groups: CCI, CCI+HBO and the control group (SHAM). Mechanical allodynia was tested daily following CCI procedure. HBO rats were treated at 2.4 atmospheres absolute (ATA) for 60 min once per day. The rats were euthanized and the spinal cord harvested on day 8 and 14 post-CCI. Detection of GABAergic cells and apoptosis was performed. The percentages of double positive stained cells (NeuN/GABA), cleaved caspase-3 or Cytochrome C in total GABAergic cells or in total NeuN positive cells were calculated.ResultsHBO significantly alleviated mechanical allodynia. CCI-induced neuropathic pain was associated with significantly increased spinal apoptotic GABA-positive neurons. HBO considerably decreased these spinal apoptotic cells. Cytochrome-C-positive neurons and cleaved caspase-3-positive neurons were also significantly higher in CCI rats. HBO significantly decreased these positive cells. Caspase-3 mRNA was also significantly higher in CCI rats. HBO reduced mRNA expression of caspase-3.ConclusionsCCI-induced neuropathic pain was associated with increased apoptotic GABAergic neurons induced by activation of key proteins of mitochondrial apoptotic pathways in the dorsal horn of the spinal cord. HBO alleviated CCI-induced neuropathic pain and reduced GABAergic neuron apoptosis. The beneficial effect of HBO may be via its inhibitory role in CCI-induced GABAergic neuron apoptosis by suppressing mitochondrial apoptotic pathways in the spinal cord.ImplicationsIncreased apoptotic GABAergic neurons induced by activation of key proteins of mitochondrial apoptotic pathways in the dorsal horn of the spinal cord is critical in CCI-induced neuropathic pain. The inhibitory role of HBO in GABAergic neuron apoptosis suppresses ongoing neuropathic pain.

Atypical pilocytic astrocytoma of adult spinal cord: A case report

2018 ◽  
pp. 1-2
Keyword(s):  
Spinal Cord ◽  
Young Adults ◽  
Case Report ◽  
Pilocytic Astrocytoma ◽  
Treatment Protocol ◽  
Pilomyxoid Astrocytoma ◽  
Standardized Treatment ◽  
Children And Young Adults ◽  
Adult Spinal Cord

Pilomyxoid astrocytoma (PMA) is an atypical subtype of pilocytic astrocytoma (PA), which presents in children and young adults. The incidence of PMA is low, so there is no standardized treatment protocol for it. Here, we present a 62-year-old woman with recurrent PMA, which is important for the understanding and treatment of the disease.

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