Studies of Non-A, Non-B Hepatitis and Characterization of the Hepatitis C Virus in Chimpanzees

2000 ◽  
pp. 1-23 ◽  
Author(s):  
D. W. Bradley
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C

scholarly journals Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Bo Wang ◽  
Luise Krüger ◽  
Patrycja Machnowska ◽  
Amare Eshetu ◽  
Barbara Gunsenheimer-Bartmeyer ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hiv 1

scholarly journals Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replicationin Vitro

2003 ◽  
Vol 278 (49) ◽  
pp. 49164-49170 ◽  
Author(s):  
Giovanni Migliaccio ◽  
Joanne E. Tomassini ◽  
Steven S. Carroll ◽  
Licia Tomei ◽  
Sergio Altamura ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C

Characterization of mimotopes mimicking an immunodominant conformational epitope on the hepatitis C virus NS3 helicase

2004 ◽  
Vol 72 (3) ◽  
pp. 385-395 ◽  
Author(s):  
Colette Jolivet-Reynaud ◽  
Anne Adida ◽  
Sandrine Michel ◽  
Gilbert Deléage ◽  
Glaucia Paranhos-Baccala ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Conformational Epitope

scholarly journals Clinico-pathological characterization of hepatitis C virus-related B-cell non-Hodgkin’s lymphomas without symptomatic cryoglobulinemia

1998 ◽  
Vol 9 (5) ◽  
pp. 495-498 ◽  
Author(s):  
M. Luppi ◽  
G. Longo ◽  
M.G. Ferrari ◽  
P. Barozzi ◽  
R. Marasca ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Hodgkin's Lymphomas

Ultrastructural and physicochemical characterization of the hepatitis C virus recovered from the serum of an agammaglobulinemic patient

1998 ◽  
Vol 143 (11) ◽  
pp. 2241-2245 ◽  
Author(s):  
A. Trestard ◽  
Y. Bacq ◽  
L. Buzelay ◽  
F. Dubois ◽  
F. Barin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Physicochemical Characterization

Characterization of clinical predictors of naturally occurring NS3/NS4A protease polymorphism in genotype 1 hepatitis C virus mono and HIV co-infected patients

2017 ◽  
Vol 89 (12) ◽  
pp. 2249-2254 ◽  
Author(s):  
Gaspar Lisboa Neto ◽  
Fernanda M. Malta ◽  
Michele S. Gomes-Gouvêa ◽  
Caroline F. Noble ◽  
Camila M. Romano ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Clinical Predictors ◽  
Naturally Occurring

scholarly journals Characterization of Functional Hepatitis C Virus Envelope Glycoproteins

2004 ◽  
Vol 78 (6) ◽  
pp. 2994-3002 ◽  
Author(s):  
Anne Op De Beeck ◽  
Cécile Voisset ◽  
Birke Bartosch ◽  
Yann Ciczora ◽  
Laurence Cocquerel ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Conformational Changes ◽  
Structural Changes ◽  
Envelope Proteins ◽  
Viral Envelope ◽  
Envelope Glycoproteins ◽  
Functional Envelope

ABSTRACT Hepatitis C virus (HCV) encodes two envelope glycoproteins, E1 and E2, that assemble as a noncovalent heterodimer which is mainly retained in the endoplasmic reticulum. Because assembly into particles and secretion from the cell lead to structural changes in viral envelope proteins, characterization of the proteins associated with the virion is necessary in order to better understand how they mature to be functional in virus entry. There is currently no efficient and reliable cell culture system to amplify HCV, and the envelope glycoproteins associated with the virion have therefore not been characterized yet. Recently, infectious pseudotype particles that are assembled by displaying unmodified HCV envelope glycoproteins on retroviral core particles have been successfully generated. Because HCV pseudotype particles contain fully functional envelope glycoproteins, these envelope proteins, or at least a fraction of them, should be in a mature conformation similar to that on the native HCV particles. In this study, we used conformation-dependent monoclonal antibodies to characterize the envelope glycoproteins associated with HCV pseudotype particles. We showed that the functional unit is a noncovalent E1E2 heterodimer containing complex or hybrid type glycans. We did not observe any evidence of maturation by a cellular endoprotease during the transport of these envelope glycoproteins through the secretory pathway. These envelope glycoproteins were recognized by a panel of conformation-dependent monoclonal antibodies as well as by CD81, a molecule involved in HCV entry. The functional envelope glycoproteins associated with HCV pseudotype particles were also shown to be sensitive to low-pH treatment. Such conformational changes are likely necessary to initiate fusion.

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