Patient Compliance in the Prophylaxis of Angina Pectoris

1988 ◽  
pp. 209-216
Author(s):  
E. Weber
Keyword(s):  
Angina Pectoris ◽  
Patient Compliance

Patient Compliance and Therapeutic Coverage: Amlodipine versus Nifedipine (Slow-Release) in the Treatment of Angina Pectoris

1994 ◽  
Vol 22 (5) ◽  
pp. 278-286 ◽  
Author(s):  
J-M R Detry ◽  
P Block ◽  
G De Backer ◽  
J-P Degaute ◽  
R Six ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Monitoring System ◽  
Patient Compliance ◽  
Slow Release ◽  
Treatment Time ◽  
Electronic Device ◽  
Time Interval ◽  
Event Monitoring ◽  
Once Daily ◽  
Correct Dose

Patient compliance with therapy is often poor and overestimated by the treating physician; it is particularly important in cardiovascular diseases such as hypertension and angina pectoris. Compliance was studied in an open parallel study in out-patients with stable angina pectoris, given either amlodipine (5 mg, once daily) or slow-release nifedipine (20 mg, twice daily) for 12 weeks. Compliance was assessed using pill counting and using an electronic device, the medication event monitoring system, to record the time and date of each opening and closure of the pill container. There was no difference between the two groups in pill count or taking ‘in compliance’ (the percentage of prescribed doses taken as indicated by the monitoring system). Compliance was significantly better ( P < 0.001) with amlodipine, however, for ‘correct dosing’ (the percentage of days on which the correct dose was taken) and for ‘timing compliance’ (the percentage of doses taken at the prescribed time interval after the last dose). ‘Therapeutic coverage’ (the estimated proportion of treatment time for which the drug was active) was also significantly better for amlodipine ( P < 0.001). There was no difference in reported side-effects between the two therapies.

Patient Compliance with Once-Daily and Twice-daily Oral Formulations of 5-Isosorbide Mononitrate: A Comparative Study

1994 ◽  
Vol 22 (5) ◽  
pp. 266-272 ◽  
Author(s):  
J Brun
Keyword(s):  
Angina Pectoris ◽  
Patient Compliance ◽  
Isosorbide Mononitrate ◽  
Daily Regimen ◽  
Stable Angina Pectoris ◽  
Event Monitoring ◽  
Release Formulation ◽  
Once Daily ◽  
Oral Formulations ◽  
To Receive

This study compares patient compliance with once- and twice-daily formulations of 5-isosorbide mononitrate. A total of 31 patients (20 men and 11 women) with stable angina pectoris were randomized to receive either 60 mg 5-isosorbide mononitrate in a controlled release formulation once daily, or 20 mg 5-isosorbide mononitrate twice daily. The results indicated that compliance assessed using the electronic Medication Event Monitoring System (MEMS®) was better with the once-daily than with the twice-daily formulation; patients on the once-daily regimen performed better with respect to the total number of bottle openings, the number of openings per day, the timing of openings and the intervals between openings. The apparently superior compliance with the once-daily regimen appeared to be reflected in better efficacy; patients on the once-daily regimen experienced fewer angina attacks (a mean of 1.7 per 7 days, compared with 3.3 per 7 days for patients on the twice-daily regimen) and used fewer nitroglycerin tablets than those on the twice-daily regimen.

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