Comments on: “The significance of shearing displacements for the mechanical stimulation of cochlear hair cells” (J. Tonndorf)

1974 ◽  
pp. 75-76
Author(s):  
P. Dallos
Keyword(s):  
Mechanical Stimulation ◽  
Hair Cells ◽  
Cochlear Hair Cells ◽  
Stimulation Of

Mechanical stimulation of individual stereocilia of living cochlear hair cells by atomic force microscopy

2000 ◽  
Vol 82 (1-4) ◽  
pp. 269-278 ◽  
Author(s):  
M.G Langer ◽  
A Koitschev ◽  
H Haase ◽  
U Rexhausen ◽  
J.K.H Hörber ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Mechanical Stimulation ◽  
Hair Cells ◽  
Cochlear Hair Cells ◽  
Force Microscopy ◽  
Atomic Force ◽  
Stimulation Of

Intracellular calcium variations evoked by mechanical stimulation of mammalian isolated vestibular type I hair cells

1994 ◽  
Vol 427 (1-2) ◽  
pp. 162-168 ◽  
Author(s):  
Christian Chabbert ◽  
Gwenaelle Geleoc ◽  
Jacques Lehouelleur ◽  
Alain Sans
Keyword(s):  
Intracellular Calcium ◽  
Mechanical Stimulation ◽  
Hair Cells ◽  
Type I ◽  
Stimulation Of

scholarly journals Direct mechanical stimulation of tip links in hair cells through DNA tethers

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Aakash Basu ◽  
Samuel Lagier ◽  
Maria Vologodskaia ◽  
Brian A Fabella ◽  
AJ Hudspeth
Keyword(s):  
Magnetic Field ◽  
Field Gradient ◽  
Mechanical Stimulation ◽  
Hair Cells ◽  
Magnetic Field Gradient ◽  
Hair Bundle ◽  
Mechanical Forces ◽  
Mechanoelectrical Transduction ◽  
Superparamagnetic Beads ◽  
Stimulation Of

Mechanoelectrical transduction by hair cells commences with hair-bundle deflection, which is postulated to tense filamentous tip links connected to transduction channels. Because direct mechanical stimulation of tip links has not been experimentally possible, this hypothesis has not been tested. We have engineered DNA tethers that link superparamagnetic beads to tip links and exert mechanical forces on the links when exposed to a magnetic-field gradient. By pulling directly on tip links of the bullfrog's sacculus we have evoked transduction currents from hair cells, confirming the hypothesis that tension in the tip links opens transduction channels. This demonstration of direct mechanical access to tip links additionally lays a foundation for experiments probing the mechanics of individual channels.

scholarly journals Author response: Direct mechanical stimulation of tip links in hair cells through DNA tethers

2016 ◽  
Author(s):  
Aakash Basu ◽  
Samuel Lagier ◽  
Maria Vologodskaia ◽  
Brian A Fabella ◽  
AJ Hudspeth
Keyword(s):  
Mechanical Stimulation ◽  
Hair Cells ◽  
Author Response ◽  
Stimulation Of

The role of fluid inertia in mechanical stimulation of hair cells

1988 ◽  
Vol 35 (2-3) ◽  
pp. 201-207 ◽  
Author(s):  
Dennis M Freeman ◽  
Thomas F Weiss
Keyword(s):  
Mechanical Stimulation ◽  
Hair Cells ◽  
Fluid Inertia ◽  
Stimulation Of
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