Droplet-Based Microfluidic Preparation of Shape-Variable Alginate Hydrogel Magnetic Micromotors

This article introduces a facile droplet-based microfluidic method for the preparation of Fe3O4-incorporated alginate hydrogel magnetic micromotors with variable shapes. By using droplet-based microfluidics and water diffusion, monodisperse (quasi-)spherical microparticles of sodium alginate and Fe3O4 (Na-Alg/Fe3O4) are obtained. The diameter varies from 31.9 to 102.7 µm with the initial concentration of Na-Alginate in dispersed fluid ranging from 0.09 to 9 mg/mL. Calcium chloride (CaCl2) is used for gelation, immediately transforming Na-Alg/Fe3O4 microparticles into Ca-Alginate hydrogel microparticles incorporating Fe3O4 nanoparticles, i.e., Ca-Alg/Fe3O4 micromotors. Spherical, droplet-like, and worm-like shapes are yielded depending on the concentration of CaCl2, which is explained by crosslinking and anisotropic swelling during the gelation. The locomotion of Ca-Alg/Fe3O4 micromotors is activated by applying external magnetic fields. Under the rotating magnetic field (5 mT, 1–15 Hz), spherical Ca-Alg/Fe3O4 micromotors exhibit an average advancing velocity up to 158.2 ± 8.6 µm/s, whereas worm-like Ca-Alg/Fe3O4 micromotors could be rotated for potential advancing. Under the magnetic field gradient (3 T/m), droplet-like Ca-Alg/Fe3O4 micromotors are pulled forward with the average velocity of 70.7 ± 2.8 µm/s. This article provides an inspiring and timesaving approach for the preparation of shape-variable hydrogel micromotors without using complex patterns or sophisticated facilities, which holds potential for biomedical applications such as targeted drug delivery.

Enhanced confinement in diverted negative-triangularity L-mode plasmas in TCV

The favourable confinement properties of negative-triangularity (NT) tokamak configurations were discovered in the TCV tokamak in the late 1990’s and were documented over the two following decades, through investigations of predominantly electron-heated plasmas in limited topologies. The most recent experimental campaign in TCV has marked a leap forward, characterized by the development of a variety of diverted NT shapes that are robustly stable with basic Ohmic heating. The application of auxiliary heating, directed now at both electrons and ions (using electron-cyclotron resonance heating as well as neutral-beam injection), has enabled the achievement of record performances for L-mode plasmas, with normalized β values reaching 2.8 transiently (as well as 2 in steady state, but reverting to a limited configuration) and with comparable ion and electron temperatures. The systematic confinement enhancement with NT is confirmed in these experiments. The L-mode existence space is broader than at positive triangularity, with only sporadic transitions to Hmode observed up to 1.4-MW heating power regardless of the magnetic-field-gradient direction relative to the X-point. These experiments are planned to be continued with even higher power following a heating-source upgrade.

Spin noise gradient echoes

Nuclear spin noise spectroscopy in the absence of radio frequency pulses was studied under the influence of pulsed field gradients (PFGs) on pure and mixed liquids. Under conditions where the radiation-damping-induced line broadening is smaller than the gradient-dependent inhomogeneous broadening, echo responses can be observed in difference spectra between experiments employing pulsed field gradient pairs of the same and opposite signs. These observed spin noise gradient echoes (SNGEs) were analyzed through a simple model to describe the effects of transient phenomena. Experiments performed on high-resolution nuclear magnetic resonance (NMR) probes demonstrate how refocused spin noise behaves and how it can be exploited to determine sample properties. In bulk liquids and their mixtures, transverse relaxation times and translational diffusion constants can be determined from SNGE spectra recorded following tailored sequences of magnetic field gradient pulses.

Magnetic Field Gradient Across the Flank Magnetopause

Magnetic pressure inside the magnetopause is usually balanced with a sum of thermal plasma and magnetic pressures on the magnetosheath side. However, observations reveal that the magnetosheath magnetic field can be frequently larger than that in the magnetosphere (inverse magnetic field gradient across the magnetopause), and thus, the enhanced pressure from the magnetosheath side seems to be uncompensated. Such events are rare in the subsolar region, but their occurrence rate increases toward flanks. The analysis, based on statistical processing of about 35,000 THEMIS magnetopause crossings collected in the course of the years 2007–2017, shows that these events are more frequently observed under enhanced geomagnetic activity that is connected with a strong southward IMF. Case studies reveal that such a state of the magnetopause boundary layers can persist for several hours. This study discusses conditions and mechanisms keeping the pressure balance across the magnetopause under these conditions.