Stereotyped Behavior and Its Relevance for Testing Neuroleptics

1980 ◽  
pp. 97-110 ◽  
Author(s):  
A. Randrup ◽  
B. Kjellberg ◽  
E. Schiørring ◽  
J. Schell-Krüger ◽  
R. Fog ◽  
...  
Keyword(s):  
Stereotyped Behavior

Effect of Sodium Valproate Pretreatment on Apomorphine and Dexamphetamine Induced Stereotyped Behavior in Rats

2012 ◽  
Author(s):  
Bhagya Sattigeri ◽  
JJ Balsara ◽  
JH Jadhav ◽  
MM Sattigeri ◽  
Astha Bhatt
Keyword(s):  
Sodium Valproate ◽  
Stereotyped Behavior

A dual approach to self-stimulation and locomotor trace affected by chronic methamphetamine treatment for an animal model of schizophrenia

1993 ◽  
Vol 71 (5-6) ◽  
pp. 321-325 ◽  
Author(s):  
Morikuni Takigawa ◽  
Hiroshi Maeda ◽  
Kenichi Ueyama ◽  
Hidefumi Tominaga ◽  
Kei Matsumoto
Keyword(s):  
Animal Model ◽  
Negative Symptoms ◽  
Disease Model ◽  
Stereotyped Behavior ◽  
Dependent Manner ◽  
Dual Approach ◽  
Reverse Tolerance ◽  
Self Stimulation ◽  
Dose Dependent

The effect of long-term methamphetamine (MAP) treatment on intracranial self-stimulation of the lateral hypotholamus and locomotor traces was assessed. An attempt was made to provide a useful animal model for understanding anhedonia, stereotypy, and reoccurrence of liability, which are analogous to symptoms of schizophrenia. The frequency of intracranial self-stimulation (ICSS) as used as a measure of the animals' "hedonic–anhedonic" state. Following long-term MAP treatment (3 mg/kg), rats gradually showed stereotyped behavior, and became inactive and unresponsive to ICSS. These behavioral changes and decreased ICSS lasted several weeks after cessation of chronic MAP treatment and seemed to suggest post-MAP chronic psychosis and (or) anhedonia, two of the negative symptoms of schizophrenia. The traces of rat behavior affected by chronic MAP treatment were classified into three types, peripheral, mixed, and fixed, occurring in a dose-dependent manner. Reverse tolerance, similar to the reoccurrence of schizophrenic symptoms, was observed as a fixed stereotypy associated with loss of ICSS. These abnormal phenomena were suppressed by pretreatment with haloperidol. In the present study, the combination of ICSS and locomotor trace affected by chronic MAP treatment was proposed as an animal model of schizophrenia and as a useful technique for gauging the effect of neuroleptics.Key words: self-stimulation, anhedonia, stereotypy, reverse tolerance, animal disease model, schizophrenia, methamphetamine.

Enhancement of amphetamine-induced stereotyped behavior by benzodiazepines

1971 ◽  
Vol 13 (3) ◽  
pp. 330-340 ◽  
Author(s):  
M. Babbini ◽  
N. Montanaro ◽  
P. Strocchi ◽  
M. Gaiardi
Keyword(s):  
Stereotyped Behavior

Flurazepam effects on methylphenidate-induced stereotyped behavior

1980 ◽  
Vol 70 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Craig Risch ◽  
Daniel Kripke ◽  
David Janowsky
Keyword(s):  
Stereotyped Behavior

Effect of cortisol on a model of stereotyped behavior of rabbits in the form of thumping

1987 ◽  
Vol 17 (4) ◽  
pp. 340-345
Author(s):  
V. P. Belyi ◽  
B. B. Gonzalez
Keyword(s):  
Stereotyped Behavior

Stereotyped Behavior

1990 ◽  
pp. 181-223 ◽  
Author(s):  
Johannes Rojahn ◽  
Lori A. Sisson
Keyword(s):  
Stereotyped Behavior

Functional connection between the stereotyped behavior and the motor front area in children with autism

2018 ◽  
Vol 32 (6) ◽  
pp. 674-677 ◽  
Author(s):  
Ming-Xia Huang ◽  
Xiao-Hui Liu ◽  
Zeng-Jun Zhang ◽  
Chao Chen ◽  
Dong Wang ◽  
...  
Keyword(s):  
Children With Autism ◽  
Stereotyped Behavior ◽  
Functional Connection

scholarly journals Ouabain Induced Stereotyped Behavior in Rats

1978 ◽  
Vol 5 (4) ◽  
pp. 401-404 ◽  
Author(s):  
D.L.W. Davidson ◽  
R.F. Butterworth ◽  
F. Bélanger ◽  
A. Barbeau
Keyword(s):  
Medulla Oblongata ◽  
Stereotyped Behavior ◽  
Stereotyped Behaviour ◽  
Dopamine Turnover ◽  
Monoamine Turnover ◽  
Behavioral Abnormalities ◽  
Norepinephrine Turnover

SUMMARY:Stereotyped behavior was inclined in rats with ouabain administered intraventricularly in doses of 2, 3 and 4 μg in 50 μl saline. Haloperiodol reduced the stereotyped behaviour. Monoamine turnover studies showed a reduction in concentration of norepinephrine in hippocampus and midbrain, an increase in norepinephrine turnover in the medulla oblongata and a reduction in dopamine turnover in the striatum. The interpretation of these finds is discussed. It is suggested that this model could be significant clinically as it demonstrates that impairment of Na+-K+-ATP'ase may result in behavioral abnormalities characterised by stereotypy.

Behavioral neurotoxicity in adolescent and adult mice exposed to fenproporex during pregnancy

2005 ◽  
Vol 24 (8) ◽  
pp. 403-408 ◽  
Author(s):  
C Q Moreira ◽  
M JSS Faria ◽  
E G Moreira
Keyword(s):  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Stereotyped Behavior ◽  
Dopaminergic Transmission ◽  
Adult Mice ◽  
Gestational Exposure ◽  
Behavioral Toxicity ◽  
Anorectic Drugs ◽  
Swimming Test ◽  
First Time

We investigated the effects of gestational exposure to fenproporex, one of the most used anorectic drugs in Brazil, on the behavior of adolescent and adult pups (30 and 60 days of age, respectively). Pregnant Swiss mice were treated daily, by gavage, with 15 mg/kg of fenproporex chloride or water during the whole gestational period. Male pups were submitted to open-field, forced swimming test, tail suspension test and fenproporexinduced stereotyped behavior. The results demonstrated that gestational exposure to fenproporex induces antidepressant-like effect and decreases fenproporexinduced stereotyped behavior in both adolescent and adult pups. Moreover, fenproporex-exposed adolescent pups tended (P–0.06) to be more active than control pups. Our data show, for the first time, that gestational exposure to fenproporex leads to long-lasting behavioral toxicity in male mice characteristic of altered dopaminergic transmission.

Stereotyped behavior in the ontogeny of rats

2007 ◽  
Vol 144 (3) ◽  
pp. 349-351 ◽  
Author(s):  
L. M. Lepekhina ◽  
E. A. Tsitsurina
Keyword(s):  
Stereotyped Behavior
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