gestational exposure
Recently Published Documents


TOTAL DOCUMENTS

354
(FIVE YEARS 89)

H-INDEX

46
(FIVE YEARS 7)

2022 ◽  
Vol 159 ◽  
pp. 107036
Author(s):  
Kim Hartley ◽  
Melinda C. MacDougall ◽  
Brandon Terrizzi ◽  
Yingying Xu ◽  
Kim M. Cecil ◽  
...  

2021 ◽  
Vol 228 ◽  
pp. 112942
Author(s):  
Liben Lin ◽  
Qiang Xu ◽  
Quanxu Chen ◽  
Haiqiong Chen ◽  
Yingfen Ying ◽  
...  

2021 ◽  
Vol 15 ◽  
Author(s):  
Itay Shekel ◽  
Shaked Giladi ◽  
Eynav Raykin ◽  
May Weiner ◽  
Vered Chalifa-Caspi ◽  
...  

Studies in rodent models suggest that calls emitted by isolated pups serve as an early behavioral manifestation of communication deficits and autistic like behavior. Previous studies in our labs showed that gestational exposure to the pesticide chlorpyrifos (CPF) and the Mthfr-knock-out mice are associated with impaired social preference and restricted or repetitive behavior. To extend these studies, we examine how pup communication via ultrasonic vocalizations is altered in these ASD models. We implemented an unsupervised hierarchical clustering method based on the spectral properties of the syllables in order to exploit syllable classification to homogeneous categories while avoiding over-categorization. Comparative exploration of the spectral and temporal aspects of syllables emitted by pups in two ASD models point to the following: (1) Most clusters showed a significant effect of the ASD factor on the start and end frequencies and bandwidth and (2) The highest percent change due to the ASD factor was on the bandwidth and duration. In addition, we found sex differences in the spectral and temporal properties of the calls in both control groups as well as an interaction between sex and the gene/environment factor. Considering the basal differences in the characteristics of syllables emitted by pups of the C57Bl/6 and Balb/c strains used as a background in the two models, we suggest that the above spectral-temporal parameters start frequency, bandwidth, and duration are the most sensitive USV features that may represent developmental changes in ASD models.


2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 318-318
Author(s):  
Cierra N Crowell ◽  
Erin B Perry

Abstract Work in other species has demonstrated an impact of gestational exposure on flavor preferences. Although equine palatability preferences in mature horses have been identified, feeding behaviors in growing horses are not well documented. The objective of this study was to evaluate the impact of exposure to common palatants in utero on feeding preferences of weanlings. Stock-type weanlings (n = 4) weighing 225(±18.15) kg at 29(±2.55) weeks of age were used in a side-by-side comparison test with a divided feeding platform. Common palatants (apple and anise) were utilized throughout the broodmare gestational period. A novel palatant, peppermint, was withheld during gestation to identify impacts associated with neophobic tendencies. Treatments were offered once daily for three consecutive days across three periods (4 weeks apart) using a pelleted concentrate feed with an application rate of 0.375 mL/0.23 kg. Weanlings were allowed free access to the feeding platform with identical pans spaced 6” apart for 20 minutes. Treatment location within the feeding platform was changed daily to limit effects associated with side-eating. Data were measured as a Chi Square test of SAS using PROC FREQ statement with α ≤. 0.05. Despite gestational exposure to apple and anise, no preference was measured in palatability assessments including First Sniff (P = 0.29), First Consumed (P = 0.70), First Finished (P = 0.29). These data suggest that exposure in utero failed to elicit a preference for common palatants in weanling horses. Additionally, these data fail to demonstrate a neophobic effect for a novel palatant, peppermint.


2021 ◽  
Vol 223 ◽  
pp. 112617
Author(s):  
Tianliang Zhang ◽  
Lijuan Sun ◽  
Tingting Wang ◽  
Chong Liu ◽  
Haoyun Zhang ◽  
...  

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Jiajianghui Li ◽  
Tianjia Guan ◽  
Qian Guo ◽  
Guannan Geng ◽  
Huiyu Wang ◽  
...  

Landscape fire smoke (LFS) has been associated with reduced birthweight, but evidence from low- and middle-income countries (LMICs) is rare. Here, we present a sibling-matched case-control study of 227,948 newborns to identify an association between fire-sourced fine particulate matter (PM2.5) and birthweight in 54 LMICs from 2000 to 2014. We selected mothers from the geocoded Demographic and Health Survey with at least two children and valid birthweight records. Newborns affiliated with the same mother were defined as a family group. Gestational exposure to LFS was assessed in each newborn using the concentration of fire-sourced PM2.5. We determined the associations of the within-group variations in LFS exposure with birthweight differences between matched siblings using a fixed-effects regression model. Additionally, we analyzed the binary outcomes of low birthweight (LBW) or very low birthweight (VLBW). According to fully adjusted models, a 1 µg/m3 increase in the concentration of fire-sourced PM2.5 was significantly associated with a 2.17 g (95% confidence interval [CI]: 0.56-3.77) reduction in birthweight, a 2.80% (95% CI: 0.97-4.66) increase in LBW risk, and an 11.68% (95% CI: 3.59-20.40) increase in VLBW risk. Our findings indicate that gestational exposure to LFS harms fetal health.


Sign in / Sign up

Export Citation Format

Share Document