Structure, Properties, and Function of Mineralized Tissue Components Group Report

1982 ◽  
pp. 327-350
Author(s):  
J. L. Matthews ◽  
H. J. Arnott ◽  
W. E. Brown ◽  
W. Dosch ◽  
V. C. Hascall ◽  
...  
Keyword(s):  
Mineralized Tissue ◽  
Group Report ◽  
And Function ◽  
Structure Properties

Steric and Electronic Effects of Ligand Substitution on Redox-Active Fe4S4-Based Coordination Polymers

2021 ◽  
Author(s):  
Omar Salinas ◽  
Jiaze Xie ◽  
Robert Papoular ◽  
Noah Horwitz ◽  
Erik Elkaim ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Ligand Substitution ◽  
Molecular Materials ◽  
Electronic Effects ◽  
Redox Active ◽  
And Function ◽  
Structure Properties

One of the notable advantages of molecular materials is the ability to precisely tune structure, properties, and function via molecular substitutions. While many studies have demonstrated this principle with classic...

scholarly journals Complementary roles of mechanotransduction and inflammation in vascular homeostasis

2021 ◽  
Vol 477 (2245) ◽  
pp. 20200622
Author(s):  
Marcos Latorre ◽  
Bart Spronck ◽  
Jay D. Humphrey
Keyword(s):  
Theoretical Model ◽  
Vascular Health ◽  
Induced Hypertension ◽  
Health And Disease ◽  
Vascular Geometry ◽  
Mechanical Homeostasis ◽  
Using Data ◽  
And Function ◽  
Insight Into ◽  
Structure Properties

Arteries are exposed to relentless pulsatile haemodynamic loads, but via mechanical homeostasis they tend to maintain near optimal structure, properties and function over long periods in maturity in health. Numerous insults can compromise such homeostatic tendencies, however, resulting in maladaptations or disease. Chronic inflammation can be counted among the detrimental insults experienced by arteries, yet inflammation can also play important homeostatic roles. In this paper, we present a new theoretical model of complementary mechanobiological and immunobiological control of vascular geometry and composition, and thus properties and function. We motivate and illustrate the model using data for aortic remodelling in a common mouse model of induced hypertension. Predictions match the available data well, noting a need for increased data for further parameter refinement. The overall approach and conclusions are general, however, and help to unify two previously disparate literatures, thus leading to deeper insight into the separate and overlapping roles of mechanobiology and immunobiology in vascular health and disease.

scholarly journals Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi

2020 ◽  
Vol 10 ◽  
Author(s):  
Wilfredo Quiñones ◽  
Héctor Acosta ◽  
Camila Silva Gonçalves ◽  
Maria Cristina M. Motta ◽  
Melisa Gualdrón-López ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
And Function ◽  
Structure Properties

scholarly journals Dental Enamel Formation and Implications for Oral Health and Disease

2017 ◽  
Vol 97 (3) ◽  
pp. 939-993 ◽  
Author(s):  
Rodrigo S. Lacruz ◽  
Stefan Habelitz ◽  
J. Timothy Wright ◽  
Michael L. Paine
Keyword(s):  
Crystal Growth ◽  
Ph Regulation ◽  
Dental Enamel ◽  
Enamel Organ ◽  
Mineralized Tissue ◽  
Enamel Formation ◽  
Health And Disease ◽  
Key Aspects ◽  
And Function ◽  
Intercellular Connections

Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate species and provides maximum durability that allows teeth to function as weapons and/or tools as well as for food processing. Enamel development and mineralization is an intricate process tightly regulated by cells of the enamel organ called ameloblasts. These heavily polarized cells form a monolayer around the developing enamel tissue and move as a single forming front in specified directions as they lay down a proteinaceous matrix that serves as a template for crystal growth. Ameloblasts maintain intercellular connections creating a semi-permeable barrier that at one end (basal/proximal) receives nutrients and ions from blood vessels, and at the opposite end (secretory/apical/distal) forms extracellular crystals within specified pH conditions. In this unique environment, ameloblasts orchestrate crystal growth via multiple cellular activities including modulating the transport of minerals and ions, pH regulation, proteolysis, and endocytosis. In many vertebrates, the bulk of the enamel tissue volume is first formed and subsequently mineralized by these same cells as they retransform their morphology and function. Cell death by apoptosis and regression are the fates of many ameloblasts following enamel maturation, and what cells remain of the enamel organ are shed during tooth eruption, or are incorporated into the tooth’s epithelial attachment to the oral gingiva. In this review, we examine key aspects of dental enamel formation, from its developmental genesis to the ever-increasing wealth of data on the mechanisms mediating ionic transport, as well as the clinical outcomes resulting from abnormal ameloblast function.

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