Biliary Lipids and Gallstone Formation

1983 ◽  
pp. 52-69 ◽  
Author(s):  
M. C. Carey
1992 ◽  
Vol 122 (4) ◽  
pp. 917-923 ◽  
Author(s):  
Martin W. Scobey ◽  
Mary S. Wolfe ◽  
Lawrence L. Rudel

2005 ◽  
Vol 5 (2) ◽  
pp. 203-208 ◽  
Author(s):  
Nahum Mendez-Sanchez ◽  
Guadalope Ponciano-Rodrigoez ◽  
Norberto Chavez-Tapia ◽  
Misael Uribe

Lipids ◽  
1985 ◽  
Vol 20 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Mary Anne Sullivan ◽  
Anne Duffy ◽  
Nancy Dimarco ◽  
George Liepa

1987 ◽  
Vol 32 (6) ◽  
pp. 609-614 ◽  
Author(s):  
Joel J. Roslyn ◽  
Robert L. Conter ◽  
Lawrence DenBesten

1988 ◽  
Vol 44 (6) ◽  
pp. 672-679 ◽  
Author(s):  
M.Samy Abdou ◽  
Seth D. Strichartz ◽  
Mohammad Z. Abedin ◽  
Joel J. Roslyn

1975 ◽  
pp. 135-194 ◽  
Author(s):  
OSCAR W. PORTMAN ◽  
TOSHIAKI OSUGA ◽  
NAOMI TANAKA

1998 ◽  
Vol 79 (5) ◽  
pp. 463-471 ◽  
Author(s):  
Elke A. Trautwein ◽  
Angelika Kunath-Rau ◽  
Helmut F. Erbersdobler

The effect of high- (hePE) and low- (lePE) esterification pectin and high- (hvGG) and low-(lvGG) viscosity guar gum on plasma, hepatic and biliary lipids and on prevention of cholesterol gallstones was investigated in male golden Syrian hamsters (Mesocricetus auratus). Hamsters were fed on cholesterol-rich (4g/kg), gallstone-inducing diets for 6 weeks. The diets were supplemented with 80g hePE, lePE, hvGG or lvGG/kg or 80g additional cellulose/kg. No significant differences in plasma total cholesterol and triacylglycerol concentrations between hvGG and lvGG and the gallstone-inducing or cellulose-enriched diets were observed. The hePE diet produced a 16% (non-significant) reduction in total plasma cholesterol but significantly decreased the plasma triacylglycerol level by 45%. The lePE diet caused only minor changes in plasma lipids. Hepatic cholesterol concentrations were significantly higher in hamsters fed on hvGG, lvGG, hePE or lePE primarily due to the accumulation of esterified cholesterol. Supersaturated bile samples, with lithogenic indices ranging from 1.6 to 2.0, were determined with all diets. The hePE and lePE diets slightly altered the bile acid profile by increasing glycocholic acid and decreasing taurochenodeoxycholic acid concentrations resulting in a higher cholic: chenodeoxycholic acid ratio. Cholesterol gallstone formation was not substantially inhibited by the two varieties of pectin and guar gum. The hvGG, lvGG, hePE and lePE diets did not alter faecal weight and caused only minor increases in faecal bile acid excretion. In general, the present findings demonstrate that dietary pectins and guar gums had only minor effects on cholesterol metabolism and did not prevent cholesterol gallstone formation in this hamster model. Possible explanations for this lack of a distinct response to pectin and guar gum are discussed.


1998 ◽  
Vol 114 ◽  
pp. A1198
Author(s):  
M. Abei ◽  
H. Kawano ◽  
T. Yano ◽  
K. Mizuguchi ◽  
J. Shoda ◽  
...  

1997 ◽  
Vol 225 (4) ◽  
pp. 382-390 ◽  
Author(s):  
Dan I. N. Giurgiu ◽  
Kimberly D. Saunders-Kirkwood ◽  
Joel J. Roslyn ◽  
Mohammad Z. Abedin

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