eicosapentaenoic acid
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2022 ◽  
Vol 62 ◽  
pp. 102615
Author(s):  
Myroslav Sprynskyy ◽  
Fernanda Monedeiro ◽  
Maciej Monedeiro-Milanowski ◽  
Zuzanna Nowak ◽  
Aneta Krakowska-Sieprawska ◽  
...  

Author(s):  
Mohammed Rehmanji ◽  
Asha Nesamma ◽  
Nida Khan ◽  
Tasneem Fatma ◽  
Pannaga Jutur

Phaeodactylum tricornutum is a marine diatom, and well-studied model of unicellular microalga. This diatom contains a wide range of high-value renewables (HVRs) with high commercial relevance owing to their importance in human nutrition and health. In this study, we screened P. tricornutum for biomass, eicosapentaenoic acid (EPA) and fucoxanthin production under photoautotrophic and mixotrophic condition with various substrate combinations. Results highlights that culture supplemented with glycerol and urea lead to enhanced biomass, biochemical and HVR production. Further continuous feeding of urea in glycerol supplemented medium results in an increase in biomass yield (0.77 g L-1) by ~ 2-fold. Additionally, continuous feeding of urea channelizes the carbon flux towards biosynthesis of fatty acids increasing FAME content by ~2-fold as compared to the control conditions. Overall EPA and fucoxanthin production was 27 mg L-1 and 11 mg L-1 (~2 & 4 fold) in urea fed cultures respectively. Present study demonstrates efficient valorization of cost-effective substrates such as glycerol and urea for the production of high-value renewables in P. tricornutum.


Author(s):  
Anna Cebrián-Prats ◽  
Alexandre Pinto ◽  
Àngels González-Lafont ◽  
Pedro Alexandrino Fernandes ◽  
José M Lluch

Specialized pro-resolving lipid mediators (SPMs) are natural bioactive agents actively involved in inflammation resolution. SPMs act when uncontrolled inflammatory processes are developed, for instance, in patients of COVID-19 or other...


2022 ◽  
Vol 61 ◽  
pp. 102586
Author(s):  
María J. Jiménez Callejón ◽  
Alfonso Robles Medina ◽  
María D. Macías Sánchez ◽  
Pedro A. González Moreno ◽  
Elvira Navarro López ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Toshinori Yasuzawa ◽  
Tomomi Nakamura ◽  
Shigeru Ueshima ◽  
Akira Mima

Diabetes-induced endothelial pathologies are hypothesized to lead to the progression of diabetic kidney disease (DKD). The endothelial to mesenchymal transition (EndMT) possibly induces fibrosis, leading to glomerulosclerosis in the kidney. Furthermore, this could lead to albuminuria in diabetic nephropathy due to glomerular endothelial dysfunction. Eicosapentaenoic acid (EPA), purified from fish oil, decreases inflammatory cytokine levels in glomerulonephritis. Here, we aimed at finding whether ethyl eicosapentaenoate (EPA-E) exerts renal protective effects via EndMT inhibition. To find out whether EPA inhibits EndMT in vitro, the changes in CD31 expression were studied in cultured mouse endothelial cells. The addition of the conditioned medium from the adipocyte culture significantly decreased the protein levels of CD31, while the addition of EPA-E partially reversed this inhibition. Further, EndMT inhibition by EPA-E treatment might occur via the inhibition of the protein kinase Cβ (PKCβ)/transforming growth factor-β (TGF-β)/plasminogen activator inhibitor-1 (PAI-1) signaling and not via microRNAs. Streptozotocin-induced diabetic mice fed a high-fat diet (60% from fat) exhibited mesangial expansion and albuminuria. Induction of EPA-E ameliorated the mesangial expansion and decreased albuminuria without affecting blood pressure, triglyceride and free fatty acid levels, and intraperitoneal glucose. These findings suggest that EPA-E exerts renal protective effects on endothelial cells, by normalizing EndMT followed by the PKCβ/TGF-β/PAI-1 signaling. Thus, EPA-E has the potential for imparting renal protection by regulating EndMT in DKD.


2021 ◽  
Vol 50 (1) ◽  
pp. 540-540
Author(s):  
Samuel Sherratt ◽  
Peter Libby ◽  
Deepak Bhatt ◽  
Hazem Dawoud ◽  
Tadeusz Malinski ◽  
...  

2021 ◽  
Vol 50 (1) ◽  
pp. 539-539
Author(s):  
Samuel Sherratt ◽  
Peter Libby ◽  
Hazem Dawoud ◽  
Deepak Bhatt ◽  
Tadeusz Malinski ◽  
...  

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