Regulation of Histone Gene Transcription in S. cerevisiae

1986 ◽  
pp. 42-48
Author(s):  
M. A. Osley ◽  
J. Gould ◽  
S. Kim ◽  
D. Lycan ◽  
L. Hereford
Keyword(s):  
Gene Transcription ◽  
Histone Gene ◽  
Histone Gene Transcription

scholarly journals Human H4 Histone Gene Transcription Requires the Proliferation-Specific Nuclear Factor HiNF-D

1989 ◽  
Vol 264 (25) ◽  
pp. 15034-15042 ◽  
Author(s):  
A J van Wijnen ◽  
K L Wright ◽  
J B Lian ◽  
J L Stein ◽  
G S Stein
Keyword(s):  
Gene Transcription ◽  
Histone Gene ◽  
Nuclear Factor ◽  
Histone Gene Transcription

Repression of histone gene transcription in quiescent 3T6 fibroblasts

1993 ◽  
Vol 217 (2) ◽  
pp. 683-690 ◽  
Author(s):  
Peter ZAHRADKA ◽  
Tracy ELLIOT ◽  
Kenneth HOVLAND ◽  
Dawn E. LARSON ◽  
Laura SAWARD
Keyword(s):  
Gene Transcription ◽  
Histone Gene ◽  
Histone Gene Transcription

scholarly journals Super resolution light microscopy of the Drosophila Histone Locus Body reveals a core-shell organization associated with expression of replication dependent histone genes

2021 ◽  
pp. mbc.E20-10-0645
Author(s):  
James P. Kemp ◽  
Xiao-Cui Yang ◽  
Zbigniew Dominski ◽  
William F. Marzluff ◽  
Robert J. Duronio
Keyword(s):  
Gene Expression ◽  
Gene Transcription ◽  
Nuclear Body ◽  
Histone Gene ◽  
Core Shell ◽  
Histone Genes ◽  
The Core ◽  
Histone Gene Expression ◽  
Histone Locus ◽  
Histone Gene Transcription

The Histone Locus Body (HLB) is an evolutionarily conserved nuclear body that regulates the transcription and processing of replication-dependent (RD) histone mRNAs, which are the only eukaryotic mRNAs lacking a poly-A tail. Many nuclear bodies contain distinct domains, but how internal organization is related to nuclear body function is not fully understood. Here, we demonstrate using structured illumination microscopy that Drosophila HLBs have a “core-shell” organization in which the internal core contains transcriptionally active RD histone genes. The N-terminus of Mxc, which contains a domain required for Mxc oligomerization, HLB assembly, and RD histone gene expression, is enriched in the HLB core. In contrast, the C-terminus of Mxc is enriched in the HLB outer shell as is FLASH, a component of the active U7 snRNP that co-transcriptionally cleaves RD histone pre-mRNA. Consistent with these results, we show biochemically that FLASH binds directly to the Mxc C-terminal region. In the rapid S-M nuclear cycles of syncytial blastoderm Drosophila embryos, the HLB disassembles at mitosis and reassembles the core-shell arrangement as histone gene transcription is activated immediately after mitosis. Thus, the core-shell organization is coupled to zygotic histone gene transcription, revealing a link between HLB internal organization and RD histone gene expression.

scholarly journals U7 small nuclear ribonucleoprotein represses histone gene transcription in cell cycle-arrested cells

2012 ◽  
Vol 109 (15) ◽  
pp. 5693-5698 ◽  
Author(s):  
T. Ideue ◽  
S. Adachi ◽  
T. Naganuma ◽  
A. Tanigawa ◽  
T. Natsume ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Gene Transcription ◽  
Histone Gene ◽  
Small Nuclear Ribonucleoprotein ◽  
Nuclear Ribonucleoprotein ◽  
Histone Gene Transcription

Nonhistone Chromosomal Proteins and Histone Gene Transcription

1977 ◽  
pp. 421-445 ◽  
Author(s):  
Gary Stein ◽  
Janet Stein ◽  
Lewis Kleinsmith ◽  
William Park ◽  
Robert Jansing ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Histone Gene ◽  
Chromosomal Proteins ◽  
Histone Gene Transcription

Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae

1992 ◽  
Vol 12 (11) ◽  
pp. 5249-5259 ◽  
Author(s):  
H Xu ◽  
U J Kim ◽  
T Schuster ◽  
M Grunstein
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cell Cycle ◽  
Dna Replication ◽  
Gene Transcription ◽  
S Phase ◽  
Histone Gene ◽  
Mrna Synthesis ◽  
Histone Mrna ◽  
Complementation Groups ◽  
Histone Gene Transcription

Histone mRNA synthesis is tightly regulated to S phase of the yeast Saccharomyces cerevisiae cell cycle as a result of transcriptional and posttranscriptional controls. Moreover, histone gene transcription decreases rapidly if DNA replication is inhibited by hydroxyurea or if cells are arrested in G1 by the mating pheromone alpha-factor. To identify the transcriptional controls responsible for cycle-specific histone mRNA synthesis, we have developed a selection for mutations which disrupt this process. Using this approach, we have isolated five mutants (hpc1, hpc2, hpc3, hpc4, and hpc5) in which cell cycle regulation of histone gene transcription is altered. All of these mutations are recessive and belong to separate complementation groups. Of these, only one (hpc1) falls in one of the three complementation groups identified previously by other means (M. A. Osley and D. Lycan, Mol. Cell. Biol. 7:4204-4210, 1987), indicating that at least seven different genes are involved in the cell cycle-specific regulation of histone gene transcription. hpc4 is unique in that derepression occurs only in the presence of hydroxyurea but not alpha-factor, suggesting that at least one of the regulatory factors is specific to histone gene transcription after DNA replication is blocked. One of the hpc mutations (hpc2) suppresses delta insertion mutations in the HIS4 and LYS2 loci. This effect allowed the cloning and sequence analysis of HPC2, which encodes a 67.5-kDa, highly charged basic protein.

scholarly journals Vertebrate histone gene transcription occurs from both DNA strands

1981 ◽  
Vol 9 (7) ◽  
pp. 1591-1598 ◽  
Author(s):  
Sam Bruschi ◽  
Julian R.E. Wells
Keyword(s):  
Gene Transcription ◽  
Histone Gene ◽  
Dna Strands ◽  
Histone Gene Transcription

Activation of in vitro histone gene transcription from HeLa S3 chromatin by S-phase nonhistone chromosomal proteins

Biochemistry ◽  
1976 ◽  
Vol 15 (15) ◽  
pp. 3296-3300 ◽  
Author(s):  
William D. Park ◽  
Janet L. Stein ◽  
Gary S. Stein
Keyword(s):  
Gene Transcription ◽  
S Phase ◽  
Histone Gene ◽  
Chromosomal Proteins ◽  
Hela S3 ◽  
Histone Gene Transcription

Regulation of histone gene transcription in yeast

2013 ◽  
Vol 71 (4) ◽  
pp. 599-613 ◽  
Author(s):  
Christoph F. Kurat ◽  
Judith Recht ◽  
Ernest Radovani ◽  
Tanja Durbic ◽  
Brenda Andrews ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Histone Gene ◽  
Histone Gene Transcription
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