Prostaglandins and Leukotrienes in the T-Helper and T-Suppressor Cell System

Antiidiotypic immunity can successfully inhibit the development of antitubular basement membrane (alpha TBM) disease that produces interstitial nephritis. Rats normally immunized to produce disease, however, do not develop this regulatory and protective antiidiotypic effect. The failure to see such a regulatory response is functionally related to the influence of a nonspecific, RT7.1+, OX8-suppressor T cell that appears shortly after immunization. While this suppressor cell system can partially reduce the intensity of disease, it also limits the host's ability to specifically regulate the alpha TBM immune response and, hypothetically, leaves the disease process in an operationally active mode.

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Defective T suppressor-inducer cell function in human immune deficiency virus-seropositive hemophilia patients

Blood ◽

10.1182/blood.v72.5.1474.bloodjournal7251474 ◽

1988 ◽

Vol 72 (5) ◽

pp. 1474-1477

Author(s):

LJ Sjamsoedin-Visser ◽

CJ Heijnen ◽

BJ Zegers ◽

JW Stoop

Keyword(s):

Immune Deficiency ◽

B Cells ◽

Cell Function ◽

Suppressor Cell ◽

T Helper Cell ◽

Helper Cell ◽

Human Immune Deficiency Virus ◽

T Helper ◽

Human Immune ◽

Hiv Seropositive

In human immune deficiency virus (HIV)-seropositive hemophilia patients, a low number of CD4 + lymphocytes is found, as well as a low CD4+/CD8+ ratio. In previous studies, it has been shown that antigen- specific T-helper cell (CD4+) function was present and no excessive antigen-specific T-suppressor cell (CD8+) function could be demonstrated. In this report, we studied another activity of CD4+ cells, namely the capacity to induce T-suppressor cell activity. The results clearly show a selective dysfunction of CD4+ suppressor-inducer (Tsi) cell function. Since these HIV-seropositive hemophilia patients showed the presence of activated B cells in the peripheral circulation refractory to antigen-specific T-helper cell signals and secreting specific antibodies spontaneously, we raised the hypothesis that the activated B cells in the patients activate the Tsi cells in vivo. This constant activation leads to a functional exhaustion of the Tsi cell pool.

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Depressed primary in vitro antibody response in untreated systemic lupus erythematosus. T helper cell defect and lack of defective suppressor cell function.

Journal of Clinical Investigation ◽

10.1172/jci109827 ◽

1980 ◽

Vol 66 (1) ◽

pp. 141-148 ◽

Cited By ~ 44

Author(s):

J F Delfraissy ◽

P Segond ◽

P Galanaud ◽

C Wallon ◽

P Massias ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Antibody Response ◽

Lupus Erythematosus ◽

Cell Function ◽

Suppressor Cell ◽

T Helper Cell ◽

T Helper ◽

Systemic Lupus ◽

Cell Defect

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A longitudinal study of patients with hemophilia: immunologic correlates of infection with HTLV-III/LAV and other viruses

Blood ◽

10.1182/blood.v66.4.973.973 ◽

1985 ◽

Vol 66 (4) ◽

pp. 973-979 ◽

Cited By ~ 35

Author(s):

SF Stein ◽

BL Evatt ◽

JS McDougal ◽

DN Lawrence ◽

RC Holman ◽

...

Keyword(s):

T Cell ◽

Health Professionals ◽

T Helper Cells ◽

Hemophilia A ◽

Suppressor Cell ◽

Cell Number ◽

T Cell Subsets ◽

Pokeweed Mitogen ◽

T Helper ◽

Helper Cells

Abstract A comprehensive study was initiated to examine the immunologic status of a sample (n = 47) of the asymptomatic hemophilia A and B populations of metropolitan Atlanta and to determine if any of the abnormalities changed with time or correlated with infection by human T cell leukemia virus type III and lymphadenopathy-associated virus (HTLV-III/LAV) or other viruses either alone or in combination. Patients with hemophilia A (Hem-A) showed a defect in cellular immunity evidenced by a depressed T cell helper/suppressor ratio (P less than .0001), an increased absolute T suppressor cell number (P less than .0001), and a diminished number of T helper cells (P = .003) when compared with health professionals. Lymphocytes from these patients also showed a reduced ability to transform in response to phytohemagglutinin and pokeweed mitogen. No deterioration in immune status was seen during a median ten- month period of follow-up. Sixty-four percent of Hem-A patients had antibodies to HTLV-III/LAV and those who were seropositive had a significantly decreased helper/suppressor cell ratio (P = .018) and a diminished T helper cell number (P = .002); they were also more likely to have had exposure to cytomegalovirus than HTLV-III/LAV-negative Hem- A patients (P = .016). Heavy use of factor VIII concentrate was associated with a decreased number of T helper cells (P = .037) and seropositivity for HTLV-III/LAV (P = .011 in 1982). Hemophilia patients had higher IgG, immune complex, and beta 2-microglobulin levels than health professionals (P less than .0001). Although the most prominent abnormality observed in T cell subsets of patients with hemophilia is an increase in T suppressor cells, a finding likely to be associated with immune augmentation in response to multiple stimuli, the T cell abnormality that was predictive of exposure to HTLV-III/LAV, the putative acquired immunodeficiency syndrome agent, was a diminished number of T helper cells.

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Variation in T helper cell/T cytotoxic-suppressor cell index during cardiac operations

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/s0022-5223(19)35165-7 ◽

1988 ◽

Vol 96 (6) ◽

pp. 962-966 ◽

Cited By ~ 11

Author(s):

M. Navarro ◽

R. Lozano ◽

L. Larrad ◽

A. Román ◽

J. Suarez ◽

...

Keyword(s):

Suppressor Cell ◽

T Helper Cell ◽

Helper Cell ◽

T Helper ◽

Cell Index ◽

Cardiac Operations

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A longitudinal study of patients with hemophilia: immunologic correlates of infection with HTLV-III/LAV and other viruses

Blood ◽

10.1182/blood.v66.4.973.bloodjournal664973 ◽

1985 ◽

Vol 66 (4) ◽

pp. 973-979

Author(s):

SF Stein ◽

BL Evatt ◽

JS McDougal ◽

DN Lawrence ◽

RC Holman ◽

...

Keyword(s):

T Cell ◽

Health Professionals ◽

T Helper Cells ◽

Hemophilia A ◽

Suppressor Cell ◽

Cell Number ◽

T Cell Subsets ◽

Pokeweed Mitogen ◽

T Helper ◽

Helper Cells

A comprehensive study was initiated to examine the immunologic status of a sample (n = 47) of the asymptomatic hemophilia A and B populations of metropolitan Atlanta and to determine if any of the abnormalities changed with time or correlated with infection by human T cell leukemia virus type III and lymphadenopathy-associated virus (HTLV-III/LAV) or other viruses either alone or in combination. Patients with hemophilia A (Hem-A) showed a defect in cellular immunity evidenced by a depressed T cell helper/suppressor ratio (P less than .0001), an increased absolute T suppressor cell number (P less than .0001), and a diminished number of T helper cells (P = .003) when compared with health professionals. Lymphocytes from these patients also showed a reduced ability to transform in response to phytohemagglutinin and pokeweed mitogen. No deterioration in immune status was seen during a median ten- month period of follow-up. Sixty-four percent of Hem-A patients had antibodies to HTLV-III/LAV and those who were seropositive had a significantly decreased helper/suppressor cell ratio (P = .018) and a diminished T helper cell number (P = .002); they were also more likely to have had exposure to cytomegalovirus than HTLV-III/LAV-negative Hem- A patients (P = .016). Heavy use of factor VIII concentrate was associated with a decreased number of T helper cells (P = .037) and seropositivity for HTLV-III/LAV (P = .011 in 1982). Hemophilia patients had higher IgG, immune complex, and beta 2-microglobulin levels than health professionals (P less than .0001). Although the most prominent abnormality observed in T cell subsets of patients with hemophilia is an increase in T suppressor cells, a finding likely to be associated with immune augmentation in response to multiple stimuli, the T cell abnormality that was predictive of exposure to HTLV-III/LAV, the putative acquired immunodeficiency syndrome agent, was a diminished number of T helper cells.

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