Determination of Phenolic Hydroxyl Groups

Author(s):  
Y.-Z. Lai
2009 ◽  
Vol 2009 (4) ◽  
pp. 229-230 ◽  
Author(s):  
Nobuhiro Sato ◽  
Hiroyuki Endo

A mild methylation of phenolic hydroxyl groups with iodomethane was enabled in the presence of sodium bis(trimethylsilyl)amide at room temperature. The reverse reaction, namely demethylation of methyl phenyl ethers, was easily achieved by microwave heating with neat iodotrimethylsilane.


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