Tyrosine phosphorylation and the mechanism of signal transduction by the B-lymphocyte antigen receptor

EJB Reviews ◽  
1993 ◽  
pp. 245-252
Author(s):  
Anthony L. Defranco
Keyword(s):  
Signal Transduction ◽  
Tyrosine Phosphorylation ◽  
B Lymphocyte ◽  
Antigen Receptor ◽  
Lymphocyte Antigen

CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor

1998 ◽  
Vol 10 (4) ◽  
pp. 287-297 ◽  
Author(s):  
Shinichi Sato ◽  
Joseph M Tuscano ◽  
Makoto Inaoki ◽  
Thomas F Tedder
Keyword(s):  
Signal Transduction ◽  
B Lymphocyte ◽  
Antigen Receptor ◽  
Lymphocyte Antigen

scholarly journals Modulation of B Lymphocyte Antigen Receptor Signal Transduction by a CD19/CD22 Regulatory Loop

Immunity ◽  
1999 ◽  
Vol 11 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Manabu Fujimoto ◽  
Alice P Bradney ◽  
Jonathan C Poe ◽  
Douglas A Steeber ◽  
Thomas F Tedder
Keyword(s):  
Signal Transduction ◽  
B Lymphocyte ◽  
Antigen Receptor ◽  
Lymphocyte Antigen ◽  
Receptor Signal ◽  
Regulatory Loop

scholarly journals CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

Immunity ◽  
1996 ◽  
Vol 5 (6) ◽  
pp. 551-562 ◽  
Author(s):  
Shinichi Sato ◽  
Ann S. Miller ◽  
Makoto Inaoki ◽  
Cheryl B. Bock ◽  
Paul J. Jansen ◽  
...  
Keyword(s):  
Signal Transduction ◽  
B Lymphocyte ◽  
Antigen Receptor ◽  
Negative Regulator ◽  
Lymphocyte Antigen ◽  
Receptor Signal ◽  
Deficient Mice

Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

Nature ◽  
1990 ◽  
Vol 345 (6278) ◽  
pp. 810-813 ◽  
Author(s):  
Michael R. Gold ◽  
Debbie A. Law ◽  
Anthony L. DeFranco
Keyword(s):  
Tyrosine Phosphorylation ◽  
B Lymphocyte ◽  
Antigen Receptor ◽  
Protein Tyrosine Phosphorylation ◽  
Lymphocyte Antigen ◽  
Protein Tyrosine ◽  
Stimulation Of

Association of B lymphocyte antigen receptor polypeptides with multiple chaperone proteins

2001 ◽  
Vol 78 (3) ◽  
pp. 149-160 ◽  
Author(s):  
Shaun P Foy ◽  
Linda Matsuuchi
Keyword(s):  
B Lymphocyte ◽  
Antigen Receptor ◽  
Chaperone Proteins ◽  
Lymphocyte Antigen

scholarly journals B lymphocyte antigen receptor signaling: initiation, amplification, and regulation

2013 ◽  
Vol 5 ◽  
Author(s):  
Thomas A. Packard ◽  
John C. Cambier
Keyword(s):  
B Lymphocyte ◽  
Antigen Receptor ◽  
Receptor Signaling ◽  
Lymphocyte Antigen ◽  
Antigen Receptor Signaling

scholarly journals Different patterns of calcium signaling triggered through two components of the B lymphocyte antigen receptor.

1994 ◽  
Vol 269 (9) ◽  
pp. 6491-6497 ◽  
Author(s):  
D. Choquet ◽  
G. Ku ◽  
S. Cassard ◽  
B. Malissen ◽  
H. Korn ◽  
...  
Keyword(s):  
Calcium Signaling ◽  
B Lymphocyte ◽  
Antigen Receptor ◽  
Lymphocyte Antigen

scholarly journals The Rac2 Guanosine Triphosphatase Regulates B Lymphocyte Antigen Receptor Responses and Chemotaxis and Is Required for Establishment of B-1a and Marginal Zone B Lymphocytes

2002 ◽  
Vol 168 (7) ◽  
pp. 3376-3386 ◽  
Author(s):  
Ben A. Croker ◽  
David M. Tarlinton ◽  
Leonie A. Cluse ◽  
Alana J. Tuxen ◽  
Amanda Light ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
B Lymphocyte ◽  
Marginal Zone ◽  
Antigen Receptor ◽  
Lymphocyte Antigen ◽  
Guanosine Triphosphatase

scholarly journals Differential T-Cell Antigen Receptor Signaling Mediated by the Src Family Kinases Lck and Fyn

2000 ◽  
Vol 20 (4) ◽  
pp. 1426-1435 ◽  
Author(s):  
Michael F. Denny ◽  
Barbara Patai ◽  
David B. Straus
Keyword(s):  
Signal Transduction ◽  
T Cell ◽  
Tyrosine Phosphorylation ◽  
Antigen Receptor ◽  
Alternative Form ◽  
Tcr Signaling ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Tcr Signal Transduction

ABSTRACT Src family tyrosine kinases play a key role in T-cell antigen receptor (TCR) signaling. They are responsible for the initial tyrosine phosphorylation of the receptor, leading to the recruitment of the ZAP-70 tyrosine kinase, as well as the subsequent phosphorylation and activation of ZAP-70. Molecular and genetic evidence indicates that both the Fyn and Lck members of the Src family can participate in TCR signal transduction; however, it is unclear to what extent they utilize the same signal transduction pathways and activate the same downstream events. We have addressed this issue by examining the ability of Fyn to mediate TCR signal transduction in an Lck-deficient T-cell line (JCaM1). Fyn was able to induce tyrosine phosphorylation of the TCR and recruitment of the ZAP-70 kinase, but the pattern of TCR phosphorylation was altered and activation of ZAP-70 was defective. Despite this, the SLP-76 adapter protein was inducibly tyrosine phosphorylated, and both the Ras–mitogen-activated protein kinase and the phosphatidylinositol 4,5-biphosphate signaling pathways were activated. TCR stimulation of JCaM1/Fyn cells induced the expression of the CD69 activation marker and inhibited cell growth, but NFAT activation and the production of interleukin-2 were markedly reduced. These results indicate that Fyn mediates an alternative form of TCR signaling which is independent of ZAP-70 activation and generates a distinct cellular phenotype. Furthermore, these findings imply that the outcome of TCR signal transduction may be determined by which Src family kinase is used to initiate signaling.

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