Human Antibodies to Pig Determinants and Their Association with Hyperacute Rejection of Xenografts

1991 ◽  
pp. 501-510 ◽  
Author(s):  
K. I. Welsh ◽  
D. H. Taube ◽  
M. Thick ◽  
A. Palmer ◽  
N. Stevens ◽  
...  
Keyword(s):  
Hyperacute Rejection ◽  
Human Antibodies

The Immunological Characterization of Human Antibodies to Factor VIII Isolated by Immuno-Affinity Chromatography

1981 ◽  
Vol 45 (01) ◽  
pp. 060-064 ◽  
Author(s):  
M L Kavanagh ◽  
C N Wood ◽  
J F Davidson
Keyword(s):  
Factor Viii ◽  
Affinity Chromatography ◽  
Gel Filtration ◽  
Immunological Characterization ◽  
Human Antibodies ◽  
Heavy Chains ◽  
Light Chain Type ◽  
Antibody Preparations ◽  
Chain Type

SummaryNine human antibodies to factor VIII were isolated from haemophilic plasmas by affinity chromatography and gel filtration and six were subsequently subjected to immunological characterization. Three partially purified preparations were similarly characterized. Eight of the antibodies were characterized as being exclusively IgG and one preparation was found to contain IgM. Seven of the antibodies contained only a single light chain type, four being of type lambda and three of type kappa. Two antibody preparations contained both kappa and lambda light chains. In four of the preparations, only a single heavy chain sub-class could be demonstrated, three of IgG3 and one of IgG4. Of the remainder, three were a mixture of IgG3 and IgG4 sub-classes and one contained both IgG2 and IgG4. IgG sub-classification could not be achieved with the IgM-containing preparation. These results demonstrate a restricted heterogeneity of light and heavy chains in human antibodies to factor VIII.

Structural Basis of Neutralization by Human Antibodies Targeting Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Gc

2020 ◽  
Author(s):  
Akaash Mishra ◽  
Jan Hellert ◽  
J. Maximilian Fels ◽  
Daniel P. Maurer ◽  
Natalia Freitas ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Structural Basis ◽  
Crimean Congo Hemorrhagic Fever ◽  
Human Antibodies ◽  
Virus Glycoprotein ◽  
Hemorrhagic Fever Virus
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