Studies on the Molecular Basis for Pathogenicity and Host Specificity in Strains of Ralstonia solanacearum Pathogenic to Banana

1998 ◽  
pp. 192-194
Author(s):  
R. Thwaites ◽  
S. Eden-Green ◽  
J. Mansfield ◽  
S. Seal
Keyword(s):  
Host Specificity ◽  
Ralstonia Solanacearum ◽  
Molecular Basis

scholarly journals PopP1, a New Member of the YopJ/AvrRxv Family of Type III Effector Proteins, Acts as a Host-Specificity Factor and Modulates Aggressiveness of Ralstonia solanacearum

2002 ◽  
Vol 15 (10) ◽  
pp. 1058-1068 ◽  
Author(s):  
Muriel Lavie ◽  
Edwin Shillington ◽  
Cédric Eguiluz ◽  
Nigel Grimsley ◽  
Christian Boucher
Keyword(s):  
Host Specificity ◽  
Ralstonia Solanacearum ◽  
Effector Proteins ◽  
Avirulence Gene ◽  
Type Iii ◽  
Secretion Pathway ◽  
Plant Infection ◽  
Hrp Genes ◽  
Specificity Factor ◽  
Bacterial Effectors

A functional analysis of an 11-kb-long region of the genome of the plant-pathogenic bacterium Ralstonia solanacearum, previously identified as an alternative codon usage region (ACUR), reveals that it was probably acquired through horizontal gene transfer. This ACUR encodes an insertion sequence and eight potential proteins, one of which is partially homologous with a host-specificity factor from a plant-pathogenic Erwinia sp., and another, PopP1, which is homologous to members of the YopJ/AvrRxv family of type III-secreted bacterial effectors controlling interaction between bacteria and their hosts. The analysis of mutants affecting all except one of the genes identified in the ACUR showed that only the popP1-deficient strain had an altered phenotype in plant infection tests. This mutant strain became pathogenic to a Petunia line that is resistant to the wild-type strain. Therefore, popP1 behaves as a typical avirulence gene. We demonstrate that PopP1 protein is secreted and that secretion of this protein requires a functional type III-secretion pathway. In contrast to the structural genes for other type III-secreted proteins identified in R. solanacearum, transcription of the popP1 gene is not coregulated with transcription of hrp genes but is constitutive.

scholarly journals Comparative genomic analysis of Ralstonia solanacearum reveals candidate genes for host specificity

BMC Genomics ◽  
2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Florent Ailloud ◽  
Tiffany Lowe ◽  
Gilles Cellier ◽  
David Roche ◽  
Caitilyn Allen ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Host Specificity ◽  
Ralstonia Solanacearum ◽  
Genomic Analysis ◽  
Comparative Genomic Analysis ◽  
Comparative Genomic

scholarly journals Molecular basis of host specificity in human pathogenic bacteria

2014 ◽  
Vol 3 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Xiaolei Pan ◽  
Yang Yang ◽  
Jing-Ren Zhang
Keyword(s):  
Host Specificity ◽  
Molecular Basis ◽  
Pathogenic Bacteria ◽  
Human Pathogenic Bacteria

Molecular basis of symbiotic host specificity in rhizobium meliloti: nodH and nodPQ genes encode the sulfation of lipo-oligosaccharide signals

Cell ◽  
1991 ◽  
Vol 67 (6) ◽  
pp. 1131-1143 ◽  
Author(s):  
Philippe Roche ◽  
Frédéric Debellé ◽  
Fabienne Maillet ◽  
Patrice Lerouge ◽  
Catherine Faucher ◽  
...  
Keyword(s):  
Host Specificity ◽  
Molecular Basis ◽  
Rhizobium Meliloti

scholarly journals The structure of the Plasmodium falciparum EBA175 ligand domain and the molecular basis of host specificity

2006 ◽  
Vol 22 (4) ◽  
pp. 143-145 ◽  
Author(s):  
Debasish Chattopadhyay ◽  
Julian Rayner ◽  
Amy M. McHenry ◽  
John H. Adams
Keyword(s):  
Plasmodium Falciparum ◽  
Host Specificity ◽  
Molecular Basis

scholarly journals Genomic insights into the host specific adaptation of the Pneumocystis genus

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ousmane H. Cissé ◽  
Liang Ma ◽  
John P. Dekker ◽  
Pavel P. Khil ◽  
Jung-Ho Youn ◽  
...  
Keyword(s):  
Host Specificity ◽  
Genome Sequence ◽  
Molecular Basis ◽  
Sequence Data ◽  
Host Adaptation ◽  
Whole Genome Sequence ◽  
Whole Genome ◽  
Specific Adaptation ◽  
Genetic Features

AbstractPneumocystis jirovecii, the fungal agent of human Pneumocystis pneumonia, is closely related to macaque Pneumocystis. Little is known about other Pneumocystis species in distantly related mammals, none of which are capable of establishing infection in humans. The molecular basis of host specificity in Pneumocystis remains unknown as experiments are limited due to an inability to culture any species in vitro. To explore Pneumocystis evolutionary adaptations, we have sequenced the genomes of species infecting macaques, rabbits, dogs and rats and compared them to available genomes of species infecting humans, mice and rats. Complete whole genome sequence data enables analysis and robust phylogeny, identification of important genetic features of the host adaptation, and estimation of speciation timing relative to the rise of their mammalian hosts. Our data reveals insights into the evolution of P. jirovecii, the sole member of the genus able to infect humans.

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