Light Chain Deposition Disease

2004 ◽  
pp. 197-203
Author(s):  
Steven R. Zeldenrust ◽  
Donna J. Lager ◽  
Nelson Leung
Keyword(s):  
Light Chain ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition

Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review

2016 ◽  
Vol 25 (1) ◽  
pp. 99-103 ◽  
Author(s):  
Benoit Brilland ◽  
Johnny Sayegh ◽  
Anne Croue ◽  
Frank Bridoux ◽  
Jean-François Subra ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Intrahepatic Cholestasis ◽  
Relevant Literature ◽  
Gamma Glutamyl Transferase ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Uncommon Presentation ◽  
Light Chain Deposition ◽  
Glutamyl Transferase

Light chain deposition disease (LCDD) is a rare multisystemic disorder associated with plasma cell proliferation. It mainly affects the kidney, but liver and heart involvement may occur, sometimes mimicking the picture of systemic amyloidosis. Liver disease in LCDD is usually asymptomatic and exceptionally manifests with severe cholestatic hepatitis. We report the case of a 66-year-old female with κ-LCDD and cast nephropathy in the setting of symptomatic multiple myeloma who, after a first cycle of bortezomib-dexamethasone chemotherapy, developed severe and rapidly worsening intrahepatic cholestasis secondary to liver κ-light chain deposition. Intrahepatic cholestasis was attributed to LCDD on the basis of the liver histology and exclusion of possible diagnoses. Chemotherapy was maintained and resulted in progressive resolution of cholestasis. We report here an uncommon presentation of LCDD, with prominent liver involvement that fully recovered with bortezomib-based chemotherapy, and briefly review the relevant literature. Abbreviations: AKI: Acute kidney injury; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; CMV: Cytomegalovirus; EBV: Epstein–Barr virus; GGT: gamma-glutamyl transferase; HSV: Herpes simplex virus; LC: light chain; LCDD: Light chain deposition disease; MIDD: Monoclonal immunoglobulin deposition disease; MM: Multiple myeloma.

scholarly journals LUNG INVOLVEMENT WITH CYSTIC CHANGES IN THE SETTING OF LIGHT CHAIN DEPOSITION DISEASE

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A1638
Author(s):  
Yahya Almodallal ◽  
Vivek Iyer ◽  
Hasan Ahmad Hasan Albitar
Keyword(s):  
Light Chain ◽  
Lung Involvement ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Cystic Changes ◽  
Light Chain Deposition

scholarly journals Light Chain Deposition Disease Diagnosed Using Computed Tomography-Guided Kidney Biopsy

Cureus ◽  
2021 ◽  
Author(s):  
Yoshinosuke Shimamura ◽  
Yayoi Ogawa ◽  
Hideki Takizawa ◽  
Toshiaki Hayashi ◽  
Yasuo Sakurai
Keyword(s):  
Computed Tomography ◽  
Light Chain ◽  
Kidney Biopsy ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition

scholarly journals Complete Primary Sequences of Two λ Immunoglobulin Light Chains in Myelomas with Nonamyloid (Randall-Type) Light Chain Deposition Disease

1998 ◽  
Vol 153 (1) ◽  
pp. 313-318 ◽  
Author(s):  
Catherine Decourt ◽  
Guy Touchard ◽  
Jean-Louis Preud'homme ◽  
Ruben Vidal ◽  
Hélène Beaufils ◽  
...  
Keyword(s):  
Light Chain ◽  
Light Chains ◽  
Immunoglobulin Light Chains ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition

scholarly journals Enlightening light chain deposition disease

Blood ◽  
2015 ◽  
Vol 126 (26) ◽  
pp. 2770-2771 ◽  
Author(s):  
Giampaolo Merlini ◽  
Giovanni Palladini
Keyword(s):  
Light Chain ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition

scholarly journals Detection and Treatment of Monoclonal Gammopathy of Renal Significance With Progression to Light Chain Deposition Disease

2017 ◽  
Vol 13 (10) ◽  
pp. 707-708 ◽  
Author(s):  
Gheorghe Ciprian Cazan ◽  
Kirk Foster ◽  
Matthew A. Lunning ◽  
Ketki Tendulkar
Keyword(s):  
Light Chain ◽  
Monoclonal Gammopathy ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Light Chain Deposition
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