A New Research on Contrast Sensitivity Function Based on Three-Dimensional Space

Author(s):  
Jiachen Yang ◽  
Yun Liu ◽  
Wei Wei ◽  
Qinggang Meng ◽  
Zhiqun Gao ◽  
...  
2016 ◽  
Vol 76 (8) ◽  
pp. 11127-11142
Author(s):  
Jiachen Yang ◽  
Yun Liu ◽  
Wei Wei ◽  
Qinggang Meng ◽  
Zhiqun Gao ◽  
...  

2015 ◽  
Vol 1 (1) ◽  
pp. 131-134 ◽  
Author(s):  
Michael Dorr ◽  
Manuel Wille ◽  
Tiberiu Viulet ◽  
Edward Sanchez ◽  
Peter J Bex ◽  
...  

AbstractThe Contrast Sensitivity Function relates the spatial frequency and contrast of a spatial pattern to its visibility and thus provides a fundamental description of visual function. However, the current clinical standard of care typically restricts assessment to visual acuity, i.e. the smallest stimulus size that can be resolved at full contrast; alternatively, tests of contrast sensitivity are typically restricted to assessment of the lowest visible contrast for a fixed letter size. This restriction to one-dimensional subspaces of a two-dimensional space was necessary when stimuli were printed on paper charts and simple scoring rules were applied manually. More recently, however, computerized testing and electronic screens have enabled more flexible stimulus displays and more complex test algorithms. For example, the quick CSF method uses a Bayesian adaptive procedure and an information maximization criterion to select only informative stimuli; testing times to precisely estimate the whole contrast sensitivity function are reduced to 2-5 minutes. Here, we describe the implementation of the quick CSF method in a medical device. We make several usability enhancements to make it suitable for use in clinical settings. A first usability study shows excellent results, with a mean System Usability Scale score of 86.5.


2016 ◽  
Vol 25 (2) ◽  
pp. 023014
Author(s):  
Johanna Rousson ◽  
Jérémy Haar ◽  
Sarah Santal ◽  
Asli Kumcu ◽  
Ljiljana Platiša ◽  
...  

2018 ◽  
Vol 42 (3) ◽  
pp. 1987-1994 ◽  
Author(s):  
Qing Li ◽  
Hong-Liang Xu ◽  
Zhong-Min Su

In this work, [6]8cyclacene and [16]trannulene are used as representative molecules to further study the aromaticity from a new research perspective by using the NICS values scan in three-dimensional space methodology. A huge difference of aromaticity has been observed in three-dimensional space through the method.


1997 ◽  
Vol 84 (1) ◽  
pp. 176-178
Author(s):  
Frank O'Brien

The author's population density index ( PDI) model is extended to three-dimensional distributions. A derived formula is presented that allows for the calculation of the lower and upper bounds of density in three-dimensional space for any finite lattice.


2019 ◽  
Author(s):  
Jumpei Morimoto ◽  
Yasuhiro Fukuda ◽  
Takumu Watanabe ◽  
Daisuke Kuroda ◽  
Kouhei Tsumoto ◽  
...  

<div> <div> <div> <p>“Peptoids” was proposed, over decades ago, as a term describing analogs of peptides that exhibit better physicochemical and pharmacokinetic properties than peptides. Oligo-(N-substituted glycines) (oligo-NSG) was previously proposed as a peptoid due to its high proteolytic resistance and membrane permeability. However, oligo-NSG is conformationally flexible and is difficult to achieve a defined shape in water. This conformational flexibility is severely limiting biological application of oligo-NSG. Here, we propose oligo-(N-substituted alanines) (oligo-NSA) as a new peptoid that forms a defined shape in water. A synthetic method established in this study enabled the first isolation and conformational study of optically pure oligo-NSA. Computational simulations, crystallographic studies and spectroscopic analysis demonstrated the well-defined extended shape of oligo-NSA realized by backbone steric effects. The new class of peptoid achieves the constrained conformation without any assistance of N-substituents and serves as an ideal scaffold for displaying functional groups in well-defined three-dimensional space, which leads to effective biomolecular recognition. </p> </div> </div> </div>


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