Axonal Injury in Head Injury

Author(s):  
P. Pilz
Keyword(s):  
1991 ◽  
Vol 54 (6) ◽  
pp. 481-483 ◽  
Author(s):  
J H Adams ◽  
D I Graham ◽  
T A Gennarelli ◽  
W L Maxwell

Author(s):  
Fang Wang ◽  
Zhen Wang ◽  
Lin Hu ◽  
Hongzhen Xu ◽  
Chao Yu ◽  
...  

This study evaluates the effectiveness of various widely used head injury criteria (HICs) in predicting vulnerable road user (VRU) head injuries due to road traffic accidents. Thirty-one real-world car-to-VRU impact accident cases with detailed head injury records were collected and replicated through the computational biomechanics method; head injuries observed in the analyzed accidents were reconstructed by using a finite element (FE)-multibody (MB) coupled pedestrian model [including the Total Human Model for Safety (THUMS) head–neck FE model and the remaining body segments of TNO MB pedestrian model], which was developed and validated in our previous study. Various typical HICs were used to predict head injuries in all accident cases. Pearson’s correlation coefficient analysis method was adopted to investigate the correlation between head kinematics-based injury criteria and the actual head injury of VRU; the effectiveness of brain deformation-based injury criteria in predicting typical brain injuries [such as diffuse axonal injury diffuse axonal injury (DAI) and contusion] was assessed by using head injury risk curves reported in the literature. Results showed that for head kinematics-based injury criteria, the most widely used HICs and head impact power (HIP) can accurately and effectively predict head injury, whereas for brain deformation-based injury criteria, the maximum principal strain (MPS) behaves better than cumulative strain damage measure (CSDM0.15 and CSDM0.25) in predicting the possibility of DAI. In comparison with the dilatation damage measure (DDM), MPS seems to better predict the risk of brain contusion.


2009 ◽  
Vol 29 (2) ◽  
pp. 132-139 ◽  
Author(s):  
Katsuhiko Maruichi ◽  
Satoshi Kuroda ◽  
Yasuhiro Chiba ◽  
Masaaki Hokari ◽  
Hideo Shichinohe ◽  
...  

Author(s):  
Minoru Shigemori ◽  
N. Kikuchi ◽  
T. Tokutomi ◽  
S. Ochiai ◽  
S. Kuramoto

1999 ◽  
Vol 8 (2) ◽  
pp. 109-115 ◽  
Author(s):  
J. M. Wild ◽  
C. S. A. Macmillan ◽  
J. M. Wardlaw ◽  
I. Marshall ◽  
J. Cannon ◽  
...  

2017 ◽  
Vol 04 (04) ◽  
pp. S2-S5 ◽  
Author(s):  
Ganne Umamaheswara Rao

AbstractA number of patients who suffer from mild head injury later on develop significant disabilities. Biomarkers help identify and quantify the extent of injury and help predict the possible functional outcome of the patients. There are promising candidate biomarkers for axonal injury (Tau) and astrocytic damage (glial fibrillary acidic protein and S100β) in traumatic brain injury. However, the biological significance of these markers cannot be confidently declared due to lack of studies with adequate sample size.


1995 ◽  
Vol 89 (6) ◽  
pp. 537-543 ◽  
Author(s):  
S. M. Gentleman ◽  
G. W. Roberts ◽  
T. A. Gennarelli ◽  
W. L. Maxwell ◽  
J. H. Adams ◽  
...  

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