Long-Term Clinical, Electrophysiological and Urodynamic Effects of Chronic Intrathecal Baclofen Infusion for Treatment of Spinal Spasticity

1995 ◽  
pp. 17-25 ◽  
Author(s):  
Patrick Mertens ◽  
M. Parise ◽  
L. Garcia-Larrea ◽  
C. Benneton ◽  
M. F. Millet ◽  
...  
Keyword(s):  
Intrathecal Baclofen

Long-term safety and efficacy of continuous intrathecal baclofen

2002 ◽  
Vol 44 (10) ◽  
Author(s):  
William M Campbell ◽  
Anne Ferrel ◽  
John F McLaughlin ◽  
Gerald A Grant ◽  
John D Loeser ◽  
...  
Keyword(s):  
Intrathecal Baclofen ◽  
Safety And Efficacy

scholarly journals Treatment of spasticity with intrathecal Baclofen administration: long-term follow-up, review of 40 patients

Spinal Cord ◽  
2004 ◽  
Vol 42 (12) ◽  
pp. 686-693 ◽  
Author(s):  
R Plassat ◽  
B Perrouin Verbe ◽  
P Menei ◽  
D Menegalli ◽  
J F Mathé ◽  
...  
Keyword(s):  
Intrathecal Baclofen ◽  
Long Term Follow Up

Occult Hydrocephalus in Children with Cerebral Palsy

Neurosurgery ◽  
2005 ◽  
Vol 56 (1) ◽  
pp. 93-97 ◽  
Author(s):  
A Leland Albright ◽  
Susan Ferson ◽  
Signe Carlos
Keyword(s):  
Cerebral Palsy ◽  
Periventricular Leukomalacia ◽  
Intrathecal Baclofen ◽  
Multicenter Studies ◽  
Csf Shunts ◽  
Csf Pressure ◽  
Intrathecal Baclofen Therapy ◽  
Children With Cerebral Palsy ◽  
Csf Leaks

Abstract OBJECTIVE: Many children with cerebral palsy have chronic ventriculomegaly as a consequence of perinatal intraventricular hemorrhage or periventricular leukomalacia, without symptoms of hydrocephalus. Children with cerebral palsy who are treated with intrathecal baclofen have a higher rate of cerebrospinal fluid (CSF) leaks along the baclofen catheter than do adults treated with intrathecal baclofen. We postulated that the cause of the increased frequency of CSF leaks was increased CSF pressure, that is, occult hydrocephalus. METHODS: Lumbar punctures were performed in 24 children with cerebral palsy and asymptomatic ventriculomegaly. Their median age was 4.7 years. Mild or moderate ventriculomegaly was present in 23 children and severe ventriculomegaly was present in 1 child. RESULTS: Opening pressures were abnormally high in 23 (96%) of 24 children and ranged from 22 to 41 cm H2O (mean, 27.3 cm H2O). Opening pressures did not correlate with the extent of ventriculomegaly. CONCLUSION: Children with cerebral palsy and ventriculomegaly seem to have a high incidence of increased CSF pressure, and thus, of occult hydrocephalus. The increased pressure is probably a significant cause of the increased frequency of CSF leaks for these children during intrathecal baclofen therapy. The long-term risks of untreated increased CSF pressures in this patient population are not known but are cause for concern. Treatment with CSF shunts offers the potential of improved development, which was reported anecdotally in some children who were treated with ventriculoperitoneal shunts after their pressure was found to be increased. Prospective multicenter studies of this problem are needed.

Occurrence of Adverse Events in Long-Term Intrathecal Baclofen Infusion: A 1-Year Follow-Up Study of 158 Adults

2014 ◽  
Vol 95 (6) ◽  
pp. 1032-1038 ◽  
Author(s):  
Léo Borrini ◽  
Djamel Bensmail ◽  
Jean-Baptiste Thiebaut ◽  
Caroline Hugeron ◽  
Célia Rech ◽  
...  
Keyword(s):  
Adverse Events ◽  
Intrathecal Baclofen ◽  
Follow Up Study

Long-term Intrathecal Baclofen: Outcomes After More than 10 Years of Treatment

PM&R ◽  
2013 ◽  
Vol 6 (6) ◽  
pp. 506-513.e1 ◽  
Author(s):  
Sunjay N. Mathur ◽  
Samuel K. Chu ◽  
Zack McCormick ◽  
George C. Chang Chien ◽  
Christina M. Marciniak
Keyword(s):  
Intrathecal Baclofen

Long-term results of chronic intrathecal baclofen treatment in patients with spasticity and secondary dystonia

2019 ◽  
Vol 119 (1) ◽  
pp. 38 ◽  
Author(s):  
A. V. Dekopov ◽  
D. L. Pashin ◽  
A. A. Tomski ◽  
E. D. Isaguljan ◽  
E. M. Salova ◽  
...  
Keyword(s):  
Intrathecal Baclofen ◽  
Long Term Results ◽  
Secondary Dystonia

Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study

1993 ◽  
Vol 78 (2) ◽  
pp. 226-232 ◽  
Author(s):  
Robert J. Coffey ◽  
David Cahill ◽  
William Steers ◽  
T. S. Park ◽  
Joe Ordia ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Intrathecal Baclofen ◽  
Neurological Deficits ◽  
Pump System ◽  
Postoperative Score ◽  
Long Term Treatment ◽  
Cord Injury

✓ A total of 93 patients with intractable spasticity due to either spinal cord injury (59 cases), multiple sclerosis (31 cases), or other spinal pathology (three cases) were entered into a randomized double-blind placebocontrolled screening protocol of intrathecal baclofen test injections. Of the 88 patients who responded to an intrathecal bolus of 50, 75, or 100 µg of baclofen, 75 underwent implantation of a programmable pump system for chronic therapy. Patients were followed for 5 to 41 months after surgery (mean 19 months). No deaths or new permanent neurological deficits occurred as a result of surgery or chronic intrathecal baclofen administration. Rigidity was reduced from a mean preoperative Ashworth scale score of 3.9 to a mean postoperative score of 1.7. Muscle spasms were reduced from a mean preoperative score of 3.1 (on a fourpoint scale) to a mean postoperative score of 1.0. Although the dose of intrathecal baclofen required to control spasticity increased with time, drug tolerance was not a limiting factor in this study. Only one patient withdrew from the study because of a late surgical complication (pump pocket infection). Another patient received an intrathecal baclofen overdose because of a human error in programming the pump. The results of this study indicate that intrathecal baclofen infusion can be safe and effective for the long-term treatment of intractable spasticity in patients with spinal cord injury or multiple sclerosis.

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