Endothelial Dysfunction After Brain Ischemia and Reperfusion

2001 ◽  
pp. 64-69
Author(s):  
Timur D. Vlasov ◽  
Victor I. Amosov ◽  
Dmitry E. Korzhevski
Keyword(s):  
Endothelial Dysfunction ◽  
Brain Ischemia ◽  
Ischemia And Reperfusion

Chronic protection against ischemia and reperfusion-induced endothelial dysfunction during therapy with different organic nitrates

2012 ◽  
Vol 101 (6) ◽  
pp. 453-459 ◽  
Author(s):  
Monica Lisi ◽  
Matthias Oelze ◽  
Saverio Dragoni ◽  
Andrew Liuni ◽  
Sebastian Steven ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Organic Nitrates ◽  
Ischemia And Reperfusion

scholarly journals HuR Function and Translational State Analysis Following Global Brain Ischemia and Reperfusion

2013 ◽  
Vol 4 (6) ◽  
pp. 589-603 ◽  
Author(s):  
Jeffrey J. Szymanski ◽  
Haihui Wang ◽  
Jill T. Jamison ◽  
Donald J. DeGracia
Keyword(s):  
Brain Ischemia ◽  
Ischemia And Reperfusion ◽  
Global Brain Ischemia ◽  
Global Brain ◽  
State Analysis

scholarly journals Calpain Mediates Eukaryotic Initiation Factor 4G Degradation during Global Brain Ischemia

1998 ◽  
Vol 18 (8) ◽  
pp. 876-881 ◽  
Author(s):  
Robert W. Neumar ◽  
Donald J. DeGracia ◽  
Lynette L. Konkoly ◽  
John I. Khoury ◽  
Blaine C. White ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Critical Role ◽  
Initiation Factor ◽  
Ischemia And Reperfusion ◽  
Eukaryotic Initiation Factor ◽  
Global Brain Ischemia ◽  
Eukaryotic Initiation Factor 4G ◽  
Global Brain ◽  
Calpain Inhibitors

Global brain ischemia and reperfusion result in the degradation of the eukaryotic initiation factor (eIF) 4G, which plays a critical role in the attachment of the mRNA to the ribosome. Because eIF-4G is a substrate of calpain, these studies were undertaken to examine whether calpain I activation during global brain ischemia contributes to the degradation of eIF-4G in vivo. Immunoblots with antibodies against calpain I and eIF-4G were prepared from rat brain postmitochondrial supernatant incubated at 37°C with and without the addition of calcium and the calpain inhibitors calpastatin or MDL-28,170. Addition of calcium alone resulted in calpain I activation (as measured by autolysis of the 80-kDa subunit) and degradation of eIF-4G; this effect was blocked by either 1 μmol/L calpastatin or 10 μmol/L MDL-28,170. In rabbits subjected to 20 minutes of cardiac arrest, immunoblots of brain postmitochondrial supernatants showed that the percentage of autolyzed calpain I increased from 1.9% ± 1.1% to 15.8% ± 5.0% and that this was accompanied by a 68% loss of eIF-4G. MDL-28,170 pretreatment (30 mg/kg) decreased ischemia-induced calpain I autolysis 40% and almost completely blocked eIF-4G degradation. We conclude that calpain I degrades eIF-4G during global brain ischemia.

Hippocampal Cellular Stress Responses After Global Brain Ischemia and Reperfusion

2007 ◽  
Vol 9 (12) ◽  
pp. 2265-2276 ◽  
Author(s):  
George G. Roberts ◽  
Mike J. Di Loreto ◽  
Monique Marshall ◽  
Jie Wang ◽  
Donald J. DeGracia
Keyword(s):  
Brain Ischemia ◽  
Stress Responses ◽  
Cellular Stress ◽  
Ischemia And Reperfusion ◽  
Global Brain Ischemia ◽  
Cellular Stress Responses ◽  
Global Brain

Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion

Neuroscience ◽  
2017 ◽  
Vol 340 ◽  
pp. 487-500 ◽  
Author(s):  
A Young Kim ◽  
Kyeong-Hoon Jeong ◽  
Jae Ho Lee ◽  
Yup Kang ◽  
Soo Hwan Lee ◽  
...  
Keyword(s):  
Glutamate Dehydrogenase ◽  
Brain Ischemia ◽  
Ischemia And Reperfusion
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