Extracolonic Cancer in Hereditary Nonpolyposis Colorectal Cancer

1990 ◽  
pp. 119-126 ◽  
Author(s):  
Patrice Watson ◽  
Henry T. Lynch
Keyword(s):  
Colorectal Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Extracolonic Cancer ◽  
Hereditary Nonpolyposis

Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population

1998 ◽  
Vol 41 (4) ◽  
pp. 428-433 ◽  
Author(s):  
Kevin M. Lin ◽  
M. Shashidharan ◽  
Charles A. Ternent ◽  
Alan G. Thorson ◽  
Garnet J. Blatchford ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
General Population ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Extracolonic Cancer ◽  
Hereditary Nonpolyposis

scholarly journals Molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)

2016 ◽  
Vol 64 (3) ◽  
pp. 537
Author(s):  
David Serrano ◽  
Clara Eugenia Arteaga
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Molecular Diagnosis ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
State Of The Art ◽  
Clinical Criteria ◽  
Extracolonic Cancer ◽  
Pubmed Database ◽  
Hereditary Nonpolyposis ◽  
Repair Genes

Lynch syndrome is the most common cause of inherited colorectal cancer, totaling 5 to 8% of all the cases with high susceptibility to this type of cancer and extracolonic cancer. It is related to germinal mutations taking place at mismatch repair genes. The diagnosis of Lynch syndrome is essential for both monitoring patients with this disease and detecting asymptomatic carriers, in order to establish appropriate clinical monitoring, preventive management and genetic counselingAlthough clinical criteria have been standardized by implementing Amsterdam I and II, as well as Bethesda guidelines, the detection rate of mutations in these genes only varies between 20% and 60%.The objective of this research was to review the state of the art regarding molecular diagnosis of Lynch syndrome; thus, a review of the literature published from 1995 to 2015 in PubMed database was performed by using the criteria “lynch syndrome molecular screening”. 19 articles were selected and reviewed, and the relevant bibliography related to such articles was also reviewed.This paper presents different approaches proposed by several researchers on molecular algorithms to improve the efficiency of Lynch syndrome diagnosis.

The results of gynecologic surveillance in families with hereditary nonpolyposis colorectal cancer

2014 ◽  
Vol 133 (3) ◽  
pp. 526-530 ◽  
Author(s):  
Zohreh Ketabi ◽  
Anne-Marie Gerdes ◽  
Berit Mosgaard ◽  
Steen Ladelund ◽  
Inge Bernstein
Keyword(s):  
Colorectal Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Hereditary Nonpolyposis

Sarcomas associated with hereditary nonpolyposis colorectal cancer: broad anatomical and morphological spectrum

2009 ◽  
Vol 8 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Mef Nilbert ◽  
Christina Therkildsen ◽  
Anja Nissen ◽  
Måns Åkerman ◽  
Inge Bernstein
Keyword(s):  
Colorectal Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Hereditary Nonpolyposis
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