Strong-Motion Networks in Italy and Their Efficient Use in the Derivation of Regional and Global Predictive Models

Author(s):  
L. Luzi ◽  
M. Massa ◽  
D. Bindi ◽  
F. Pacor
2018 ◽  
Vol 12 (5-6) ◽  
pp. 72-80
Author(s):  
A. A. Krylov

In the absence of strong motion records at the future construction sites, different theoretical and semi-empirical approaches are used to estimate the initial seismic vibrations of the soil. If there are records of weak earthquakes on the site and the parameters of the fault that generates the calculated earthquake are known, then the empirical Green’s function can be used. Initially, the empirical Green’s function method in the formulation of Irikura was applied for main shock record modelling using its aftershocks under the following conditions: the magnitude of the weak event is only 1–2 units smaller than the magnitude of the main shock; the focus of the weak event is localized in the focal region of a strong event, hearth, and it should be the same for both events. However, short-termed local instrumental seismological investigation, especially on seafloor, results usually with weak microearthquakes recordings. The magnitude of the observed micro-earthquakes is much lower than of the modeling event (more than 2). To test whether the method of the empirical Green’s function can be applied under these conditions, the accelerograms of the main shock of the earthquake in L'Aquila (6.04.09) with a magnitude Mw = 6.3 were modelled. The microearthquake with ML = 3,3 (21.05.2011) and unknown origin mechanism located in mainshock’s epicentral zone was used as the empirical Green’s function. It was concluded that the empirical Green’s function is to be preprocessed. The complex Fourier spectrum smoothing by moving average was suggested. After the smoothing the inverses Fourier transform results with new Green’s function. Thus, not only the amplitude spectrum is smoothed out, but also the phase spectrum. After such preliminary processing, the spectra of the calculated accelerograms and recorded correspond to each other much better. The modelling demonstrate good results within frequency range 0,1–10 Hz, considered usually for engineering seismological studies.


2021 ◽  
Author(s):  
Norberto Sánchez-Cruz ◽  
Jose L. Medina-Franco

<p>Epigenetic targets are a significant focus for drug discovery research, as demonstrated by the eight approved epigenetic drugs for treatment of cancer and the increasing availability of chemogenomic data related to epigenetics. This data represents a large amount of structure-activity relationships that has not been exploited thus far for the development of predictive models to support medicinal chemistry efforts. Herein, we report the first large-scale study of 26318 compounds with a quantitative measure of biological activity for 55 protein targets with epigenetic activity. Through a systematic comparison of machine learning models trained on molecular fingerprints of different design, we built predictive models with high accuracy for the epigenetic target profiling of small molecules. The models were thoroughly validated showing mean precisions up to 0.952 for the epigenetic target prediction task. Our results indicate that the herein reported models have considerable potential to identify small molecules with epigenetic activity. Therefore, our results were implemented as freely accessible and easy-to-use web application.</p>


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