The Role of Cytochrome P450 2E1 in Ethanol-Mediated Carcinogenesis

2013 ◽  
pp. 131-143 ◽  
Author(s):  
Helmut K. Seitz ◽  
Xiang-Dong Wang
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2E1

scholarly journals The role of cytochrome P450 2E1 on ethanol-mediated oxidative stress and HIV replication in human monocyte-derived macrophages

2019 ◽  
Vol 17 ◽  
pp. 65-70 ◽  
Author(s):  
Yuqing Gong ◽  
P.S.S. Rao ◽  
Namita Sinha ◽  
Sabina Ranjit ◽  
Theodore J. Cory ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cytochrome P450 ◽  
Human Monocyte ◽  
Cytochrome P450 2E1 ◽  
Hiv Replication

scholarly journals Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 288
Author(s):  
Julie Massart ◽  
Karima Begriche ◽  
Jessica H. Hartman ◽  
Bernard Fromenty
Keyword(s):  
Oxidative Stress ◽  
Cytochrome P450 ◽  
Liver Disease ◽  
Fatty Liver ◽  
Current Knowledge ◽  
Physiological Role ◽  
Experimental Investigations ◽  
Rat Liver Mitochondria ◽  
Cytochrome P450 2E1

Cytochrome P450 2E1 (CYP2E1) is pivotal in hepatotoxicity induced by alcohol abuse and different xenobiotics. In this setting, CYP2E1 generates reactive metabolites inducing oxidative stress, mitochondrial dysfunction and cell death. In addition, this enzyme appears to play a role in the progression of obesity-related fatty liver to nonalcoholic steatohepatitis. Indeed, increased CYP2E1 activity in nonalcoholic fatty liver disease (NAFLD) is deemed to induce reactive oxygen species overproduction, which in turn triggers oxidative stress, necroinflammation and fibrosis. In 1997, Avadhani’s group reported for the first time the presence of CYP2E1 in rat liver mitochondria, and subsequent investigations by other groups confirmed that mitochondrial CYP2E1 (mtCYP2E1) could be found in different experimental models. In this review, we first recall the main features of CYP2E1 including its role in the biotransformation of endogenous and exogenous molecules, the regulation of its expression and activity and its involvement in different liver diseases. Then, we present the current knowledge on the physiological role of mtCYP2E1, its contribution to xenobiotic biotransformation as well as the mechanism and regulation of CYP2E1 targeting to mitochondria. Finally, we discuss experimental investigations suggesting that mtCYP2E1 could have a role in alcohol-associated liver disease, xenobiotic-induced hepatotoxicity and NAFLD.

Role of Cytochrome P450 2E1 in the Metabolism of Acrylamide and Acrylonitrile in Mice

1999 ◽  
Vol 12 (11) ◽  
pp. 1110-1116 ◽  
Author(s):  
Susan C. J. Sumner ◽  
Timothy R. Fennell ◽  
Timothy A. Moore ◽  
Brian Chanas ◽  
Frank Gonzalez ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2E1

Role of Medium-Chain Triglycerides in the Alcohol-Mediated Cytochrome P450 2E1 Induction of Mitochondria

2007 ◽  
Vol 31 (10) ◽  
pp. 1660-1668 ◽  
Author(s):  
Charles S. Lieber ◽  
Qi Cao ◽  
Leonore M. DeCarli ◽  
Maria A. Leo ◽  
Ki M. Mak ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2E1 ◽  
Medium Chain Triglycerides ◽  
Medium Chain

scholarly journals In vivo Role of Cytochrome P450 2E1 and Glutathione-S-Transferase Activity for Acrylamide Toxicokinetics in Humans

2009 ◽  
Vol 18 (2) ◽  
pp. 433-443 ◽  
Author(s):  
Oxana Doroshyenko ◽  
Uwe Fuhr ◽  
Daria Kunz ◽  
Dorothee Frank ◽  
Martina Kinzig ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Transferase Activity ◽  
Cytochrome P450 2E1 ◽  
Glutathione S Transferase

Role of glucose utilization in the restoration of hypophysectomy-induced hepatic cytochrome P450 2E1 by growth hormone in rats

2000 ◽  
Vol 127 (1) ◽  
pp. 13-28 ◽  
Author(s):  
Moon Ho Son ◽  
Keon Wook Kang ◽  
Eun Jung Kim ◽  
Ji Hwa Ryu ◽  
Hyeon Cho ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cytochrome P450 ◽  
Glucose Utilization ◽  
Cytochrome P450 2E1 ◽  
Hepatic Cytochrome

Fish Oil, Alcohol, and Liver Pathology: Role of Cytochrome P450 2E1

1994 ◽  
Vol 207 (2) ◽  
pp. 197-205 ◽  
Author(s):  
M. Morimoto ◽  
M. A. Zern ◽  
A.- L. Hagbjork ◽  
M. Ingelman-Sundberg ◽  
S. W. French
Keyword(s):  
Cytochrome P450 ◽  
Fish Oil ◽  
Liver Pathology ◽  
Cytochrome P450 2E1

scholarly journals Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity

2010 ◽  
Vol 79 (1) ◽  
pp. 57-66 ◽  
Author(s):  
Mohamed A. Abdelmegeed ◽  
Kwan-Hoon Moon ◽  
Chi Chen ◽  
Frank J. Gonzalez ◽  
Byoung-Joon Song
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2E1 ◽  
Protein Nitration ◽  
Acetaminophen Toxicity
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