The Effects of Sarcomere Length on Force and Velocity of Shortening in Cardiac Muscle

1988 ◽  
pp. 67-79 ◽  
Author(s):  
H. E. D. J. ter Keurs ◽  
B. Wohlfart ◽  
L. Ricciardi ◽  
J. J. J. Bucx
Keyword(s):  
Cardiac Muscle ◽  
Sarcomere Length ◽  
Velocity Of Shortening

Force, velocity of shortening and sarcomere length in cardiac muscle

1985 ◽  
Vol 19 (9) ◽  
pp. 518-518
Author(s):  
H E D J T. KEURS ◽  
B WOHLFART ◽  
L RICCIARDI ◽  
B J M MULDER ◽  
J J J BUCX ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Sarcomere Length ◽  
Velocity Of Shortening ◽  
Force Velocity

Morphological Basis of the Disparity Between Muscle Length and Sarcomere Length in the Myocardium

1973 ◽  
Vol 31 ◽  
pp. 422-423
Author(s):  
G.E. Adomian ◽  
L. Chuck ◽  
W.W. Pannley
Keyword(s):  
Cardiac Muscle ◽  
Sarcomere Length ◽  
Muscle Length ◽  
Contractile Force ◽  
Direct Function ◽  
Morphological Basis ◽  
Tension Curve

Sonnenblick, et al, have shown that sarcomeres change length as a function of cardiac muscle length along the ascending portion of the length-tension curve. This allows the contractile force to be expressed as a direct function of sarcomere length. Below L max, muscle length is directly related to sarcomere length at lengths greater than 85% of optimum. However, beyond the apex of the tension-length curve, i.e. L max, a disparity occurs between cardiac muscle length and sarcomere length. To account for this disproportionate increase in muscle length as sarcomere length remains relatively stable, the concept of fiber slippage was suggested as a plausible explanation. These observations have subsequently been extended to the intact ventricle.

The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment

1997 ◽  
Vol 273 (5) ◽  
pp. H2428-H2435 ◽  
Author(s):  
Thomas Wannenburg ◽  
Paul M. L. Janssen ◽  
Dongsheng Fan ◽  
Pieter P. De Tombe
Keyword(s):  
Cardiac Muscle ◽  
Maximum Rate ◽  
Sarcomere Length ◽  
Myosin Head ◽  
Isometric Force ◽  
Force Development ◽  
Cross Bridge ◽  
Average Slope ◽  
The Cross ◽  
Kinetics Of

We tested the hypothesis that the Frank-Starling relationship is mediated by changes in the rate of cross-bridge detachment in cardiac muscle. We simultaneously measured isometric force development and the rate of ATP consumption at various levels of Ca2+ activation in skinned rat cardiac trabecular muscles at three sarcomere lengths (2.0, 2.1, and 2.2 μm). The maximum rate of ATP consumption was 1.5 nmol ⋅ s−1 ⋅ μl fiber vol−1, which represents an estimated adenosinetriphosphatase (ATPase) rate of ∼10 s−1 per myosin head at 24°C. The rate of ATP consumption was tightly and linearly coupled to the level of isometric force development, and changes in sarcomere length had no effect on the slope of the force-ATPase relationships. The average slope of the force-ATPase relationships was 15.5 pmol ⋅ mN−1 ⋅ mm−1. These results suggest that the mechanisms that underlie the Frank-Starling relationship in cardiac muscle do not involve changes in the kinetics of the apparent detachment step in the cross-bridge cycle.

scholarly journals Engineered Thin Filament Mutations to Study the Sarcomere Length Dependence of Cardiac Muscle Contractility

2018 ◽  
Vol 114 (3) ◽  
pp. 313a-314a
Author(s):  
Joseph D. Powers ◽  
Farid Moussavi-Harami ◽  
Jil C. Tardiff ◽  
Jennifer Davis ◽  
Michael Regnier
Keyword(s):  
Cardiac Muscle ◽  
Thin Filament ◽  
Sarcomere Length ◽  
Muscle Contractility ◽  
Length Dependence

High-Speed Digital Data Acquisition of Sarcomere Length from Isolated Skeletal and Cardiac Muscle Cells

1983 ◽  
Vol BME-30 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Richard L. Lieber ◽  
Kenneth P. Roos ◽  
Bradford A. Lubell ◽  
James W. Cline ◽  
Ronald J. Baskin
Keyword(s):  
Data Acquisition ◽  
Cardiac Muscle ◽  
High Speed ◽  
Sarcomere Length ◽  
Muscle Cells ◽  
Digital Data ◽  
Cardiac Muscle Cells ◽  
Digital Data Acquisition

scholarly journals Cardiac muscle mechanics: Sarcomere length matters

2016 ◽  
Vol 91 ◽  
pp. 148-150 ◽  
Author(s):  
Pieter P. de Tombe ◽  
Henk E.D.J. ter Keurs
Keyword(s):  
Cardiac Muscle ◽  
Sarcomere Length ◽  
Muscle Mechanics ◽  
Cardiac Muscle Mechanics

Effects of anisosmotic stress on cardiac muscle cell length, diameter, area, and sarcomere length

1996 ◽  
Vol 270 (4) ◽  
pp. H1414-H1422
Author(s):  
R. Tanaka ◽  
M. A. Barnes ◽  
G. Cooper ◽  
M. R. Zile
Keyword(s):  
Cardiac Muscle ◽  
Muscle Cell ◽  
Sarcomere Length ◽  
Cardiac Muscle Cell ◽  
Passive Stiffness ◽  
Future Studies ◽  
Percent Change ◽  
Cross Bridge ◽  
Butanedione Monoxime ◽  
Size Relation

The purpose of this study was to examine the effects of anisosmotic stress on adult mammalian cardiac muscle cell (cardiocyte) size. Cardiocyte size and sarcomere length were measured in cardiocytes isolated from 10 normal rats and 10 normal cats. Superfusate osmolarity was decreased from 300 +/- 6 to 130 +/- 5 mosM and increased to 630 +/- 8 mosM. Cardiocyte size and sarcomere length increased progressively when osmolarity was decreased, and there were no significant differences between cat and rat cardiocytes with respect to percent change in cardiocyte area or diameter; however, there were significant differences in cardiocyte length (2.8 +/- 0.3% in cat vs. 6.1 +/- 0.3% in rat, P < 0.05) and sarcomere length (3.3 +/- 0.3% in cat vs. 6.1 +/- 0.3% in rat, P < 0.05). To determine whether these species-dependent differences in length were related to diastolic interaction of the contractile elements or differences in relative passive stiffness, cardiocytes were subjected to the osmolarity gradient 1) during treatment with 7 mM 2,3-butanedione monoxime (BDM), which inhibits cross-bridge interaction, or 2) after pretreatment with 1 mM ethylene glycol-bis(beta-aminoethyl ether)-N, N,N',N'-tetraacetic acid (EGTA), a bivalent Ca2+ chelator. Treatment with EGTA or BDM abolished the differences between cat and rat cardiocytes. Species-dependent differences therefore appeared to be related to the degree of diastolic cross-bridge association and not differences in relative passive stiffness. In conclusion, the osmolarity vs. cell size relation is useful in assessing the cardiocyte response to anisosmotic stress and may in future studies be useful in assessing changes in relative passive cardiocyte stiffness produced by pathological processes.

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