Arrythythmias in hypertrophic cardiomyopathy: prognostic significance and clinical relevance

1985 ◽  
pp. 21-31 ◽  
Author(s):  
J. W. Viersma ◽  
D. J. Van Veldhuisen ◽  
J. P. M. Hamer ◽  
D. S. Postma ◽  
E. Van Der Wall
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Clinical Relevance ◽  
Prognostic Significance

scholarly journals Prognostic significance of cardiac magnetic resonance-based markers in patients with hypertrophic cardiomyopathy

2021 ◽  
Author(s):  
Zsofia Dohy ◽  
Liliana Szabo ◽  
Attila Toth ◽  
Csilla Czimbalmos ◽  
Rebeka Horvath ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
Myocardial Fibrosis ◽  
Ventricular Arrhythmias ◽  
Prognostic Significance ◽  
Strain Analysis ◽  
Left Ventricular ◽  
Icd Therapy ◽  
Lv Mass

AbstractThe prognosis of patients with hypertrophic cardiomyopathy (HCM) varies greatly. Cardiac magnetic resonance (CMR) is the gold standard method for assessing left ventricular (LV) mass and volumes. Myocardial fibrosis can be noninvasively detected using CMR. Moreover, feature-tracking (FT) strain analysis provides information about LV deformation. We aimed to investigate the prognostic significance of standard CMR parameters, myocardial fibrosis, and LV strain parameters in HCM patients. We investigated 187 HCM patients who underwent CMR with late gadolinium enhancement and were followed up. LV mass (LVM) was evaluated with the exclusion and inclusion of the trabeculae and papillary muscles (TPM). Global LV strain parameters and mechanical dispersion (MD) were calculated. Myocardial fibrosis was quantified. The combined endpoint of our study was all-cause mortality, heart transplantation, malignant ventricular arrhythmias and appropriate implantable cardioverter defibrillator (ICD) therapy. The arrhythmia endpoint was malignant ventricular arrhythmias and appropriate ICD therapy. The LVM index (LVMi) was an independent CMR predictor of the combined endpoint independent of the quantification method (p < 0.01). The univariate predictors of the combined endpoint were LVMi, global longitudinal (GLS) and radial strain and longitudinal MD (MDL). The univariate predictors of arrhythmia events included LVMi and myocardial fibrosis. More pronounced LV hypertrophy was associated with impaired GLS and increased MDL. More extensive myocardial fibrosis correlated with impaired GLS (p < 0.001). LVMi was an independent CMR predictor of major events, and myocardial fibrosis predicted arrhythmia events in HCM patients. FT strain analysis provided additional information for risk stratification in HCM patients.

Prognostic Significance of Fragmented QRS in Patients with Hypertrophic Cardiomyopathy

Cardiology ◽  
2017 ◽  
Vol 138 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Xili Lu ◽  
Wei Wang ◽  
Ling Zhu ◽  
Yilu Wang ◽  
Kai Sun ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Clinical Outcomes ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Cox Regression Analysis ◽  
Fragmented Qrs ◽  
All Cause Mortality ◽  
The Relationship ◽  
Cvd Mortality

Objectives: The relationship between a fragmented QRS (fQRS) and clinical outcomes in patients with hypertrophic cardiomyopathy (HCM) remains unclear. This study aimed to investigate the prognostic significance of fQRS in patients with HCM. Methods: Between 2000 and 2012, 326 unrelated patients with HCM (72% male with a mean age of 52 years) were included and were divided into 2 groups: those with fQRS and those without fQRS. Results: A total of 105/326(32.2%) patients with HCM presented with fQRS at enrollment. During a follow-up of 5.3 ± 2.4 years, 33 patients died, 30 of cardiovascular disease (CVD). Cox regression analysis revealed that fQRS predicted a higher risk of all-cause mortality (adjusted hazard ratio [HR] 2.24; 95% confidence interval [CI] 1.08-4.64; p = 0.030) and CVD mortality (adjusted HR 2.68; 95% CI 1.22-5.91; p = 0.014). Our study also showed that fQRS increased the risk of heart failure-related death (adjusted HR 3.75; 95% CI 1.24-11.30; p = 0.019). Conclusions: Our results indicate that fQRS is associated with adverse clinical outcomes in patients with HCM.

scholarly journals Inversion of the normal interatrial septum convexity in acute myocardial infarction: Incidence, clinical relevance and prognostic significance

1990 ◽  
Vol 15 (4) ◽  
pp. 801-805 ◽  
Author(s):  
José López-Sendón ◽  
Esteban López de Sá ◽  
Immaculada Roldán ◽  
Rafael Fernández de Soria ◽  
Francisco Ramos ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Clinical Relevance ◽  
Prognostic Significance ◽  
Interatrial Septum

scholarly journals Prognostic Significance of Non-Dilated Left Ventricular Size and Mitral Regurgitation in Patients With Dilated Phase of Hypertrophic Cardiomyopathy

2017 ◽  
Vol 58 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Toru Kubo ◽  
Yuichi Baba ◽  
Takayoshi Hirota ◽  
Katsutoshi Tanioka ◽  
Naohito Yamasaki ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Mitral Regurgitation ◽  
Prognostic Significance ◽  
Left Ventricular ◽  
Ventricular Size ◽  
Left Ventricular Size

Prevalence, determinants, and prognostic significance of exercise-induced pulmonary hypertension in patients with hypertrophic cardiomyopathy

2019 ◽  
Vol 35 (5) ◽  
pp. 837-844
Author(s):  
Yasuhiro Hamatani ◽  
Makoto Amaki ◽  
Rika Yonezawa ◽  
Yoshiki Yanagi ◽  
Yoshito Jo ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Hypertrophic Cardiomyopathy ◽  
Prognostic Significance ◽  
Exercise Induced

Prognostic Significance of the Mitral L-Wave in Patients With Hypertrophic Cardiomyopathy

2020 ◽  
Vol 130 ◽  
pp. 130-136
Author(s):  
Chihiro Saito ◽  
Yuichiro Minami ◽  
Kotaro Arai ◽  
Shintaro Haruki ◽  
Shota Shirotani ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Prognostic Significance

scholarly journals Spectrum and prognostic significance of arrhythmias on ambulatory Holter electrocardiogram in hypertrophic cardiomyopathy

2005 ◽  
Vol 45 (5) ◽  
pp. 697-704 ◽  
Author(s):  
A. Selcuk Adabag ◽  
Susan A. Casey ◽  
Michael A. Kuskowski ◽  
Andrey G. Zenovich ◽  
Barry J. Maron
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Prognostic Significance

scholarly journals Prognostic Significance of Myocardial Fibrosis in Hypertrophic Cardiomyopathy

2010 ◽  
Vol 56 (11) ◽  
pp. 867-874 ◽  
Author(s):  
Rory O'Hanlon ◽  
Agata Grasso ◽  
Michael Roughton ◽  
James C. Moon ◽  
Susan Clark ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Myocardial Fibrosis ◽  
Prognostic Significance

Prognostic significance of indium-111 antimyosin antibody uptake in patients with dilated and hypertrophic cardiomyopathy

1991 ◽  
Vol 32 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Akira Matsumori ◽  
Takehiko Yamada ◽  
Nagara Tamaki ◽  
Yuji Watanabe ◽  
Yoshiharu Yonekura ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Prognostic Significance ◽  
Antimyosin Antibody ◽  
Antibody Uptake ◽  
Indium 111

Prognostic Significance of Exercise Induced Arrhythmias and Echocardiographic Variables in Hypertrophic Cardiomyopathy

2007 ◽  
Vol 99 (6) ◽  
pp. 835-838 ◽  
Author(s):  
T. Jared Bunch ◽  
Krishnaswamy Chandrasekaran ◽  
Jo-Ellen Ehrsam ◽  
Stephen C. Hammill ◽  
Lynn H. Urban ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Prognostic Significance ◽  
Exercise Induced
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