Chromosome Abnormalities in Adult Acute Leukemia: Biologic and Therapeutic Significance

1982 ◽  
pp. 127-153 ◽  
Author(s):  
Harvey M. Golomb
Keyword(s):  
Acute Leukemia ◽  
Chromosome Abnormalities

Changes in the Group A Antigen in a Case of Acute Myeloblastic Leukemia

Blood ◽  
1962 ◽  
Vol 19 (5) ◽  
pp. 566-572 ◽  
Author(s):  
ADELA BARTOVA ◽  
Z. NOVOTNY ◽  
J. SLEPICKA
Keyword(s):  
Acute Leukemia ◽  
Somatic Mutation ◽  
Clinical Course ◽  
B Chromosome ◽  
Chromosome Abnormalities ◽  
Metabolic Changes ◽  
Acute Myeloblastic Leukemia ◽  
Red Cells ◽  
Hemopoietic Tissue ◽  
Group A

Abstract 1. The authors describe a case of acute leukemia in a man of 36 years. During the course of his illness, a change in the agglutinability of the red cells was observed. The cells, originally A1, changed continuously so that in some samples it was possible to detect as many as three populations of red cells, namely, A1, weak A, and so-called non-A. In the course of the illness, fluctuations in the numbers of these cells in the whole population could be observed. 2. The clinical course and the results of detailed isoserologic examinations are presented. 3. Possible causes of these changes are discussed: (a) Somatic mutation; (b) chromosome abnormalities; (c) metabolic changes of the hemopoietic tissue.

scholarly journals Preferential involvement of chromosomes no. 8 and no. 21 in acute leukemia and preleukemia

Blood ◽  
1976 ◽  
Vol 47 (4) ◽  
pp. 679-686 ◽  
Author(s):  
K Yamada ◽  
S Furusawa
Keyword(s):  
Acute Leukemia ◽  
Bone Marrow Cells ◽  
Direct Method ◽  
Chromosome Abnormalities ◽  
Myelogenous Leukemia ◽  
Banding Technique ◽  
Structural Alterations ◽  
Exact Identification ◽  
A Direct Method ◽  
Made In

Abstract Chromosome analyses were performed by a direct method on bone marrow cells of 147 patients with acute leukemia and preleukemia; in 53 chromosomally abnormal cell lines were found. Chromosome abnormalities due to structural alterations were observed in 48% of the aneuploid patients. Using the ASG banding technique, the exact identification of the abnormal chromosomes was successfully made in 22 aneuploid patients. Even though variability between patients existed in the chromosome changes; the nonrandom occurrence of some chromosome abnormalities was revealed, involving most frequently chromosomes No. 8 and No. 21. Abnormalities of chromosome No. 22 were not encountered, contrasting sharply with the frequent involvement of this chromosome in chronic myelogenous leukemia. The significance of the preferential involvement of No. 8 and No. 21 chromosomes is discussed in relation to leukemogenesis.

Chromosome abnormalities in acute leukemia: A higher incidence than previously assumed

1983 ◽  
Vol 9 (3) ◽  
pp. 305-306 ◽  
Author(s):  
Joseph R. Testa ◽  
Nobuo Oguma ◽  
Shinichi Misawa ◽  
Peter H. Wiernik
Keyword(s):  
Acute Leukemia ◽  
Chromosome Abnormalities

scholarly journals Chromosome abnormalities in Down's syndrome patients with acute leukemia

Blood ◽  
1981 ◽  
Vol 58 (3) ◽  
pp. 459-466 ◽  
Author(s):  
Y Kaneko ◽  
JD Rowley ◽  
D Variakojis ◽  
RR Chilcote ◽  
JW Moohr ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Early Stage ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Giemsa Stain ◽  
Chromosome Abnormalities ◽  
Leukemic Cells ◽  
Myeloid Differentiation ◽  
Acute Nonlymphocytic Leukemia ◽  
Blast Cells

Chromosome and cytologic studies were performed on three Down's syndrome (DS) patients with acute nonlymphocytic leukemia (ANLL). All three patients had an aneuploid clone in their leukemic cells: 50, XX, +6, +19, +21, +22, +8, XX, +21, and 47,XY, +8, - 21 +dic(21;21)(p13;p11). Every patient appeared to have acute undifferentiated leukemia when the blast cells were examined with Wright-Giemsa stain; cytochemistry studies, however, showed that the leukemic blasts were in an early stage of myeloid differentiation. The two patients with +8 had a preleukemic phase; the blast cells of the patient with an extra no. 19 and no.22 could not be differentiated morphologically from those of the two patients with an extra no. 8. Our findings and a review of data on 40 other patients suggest that most DS children with ANLL have hyperdiploidy, which is usually related to gains of C, F, and /or G chromosomes, and that the abnormalities of +8 and of +19, +22 in DS children may be associated with acute leukemia (AL) in an early stage of myeloid differentiation.

Balanced chromosome abnormalities inv(16) and t(15;17) in therapy-related myelodysplastic syndromes and acute leukemia: Report from an International Workshop

2002 ◽  
Vol 33 (4) ◽  
pp. 395-400 ◽  
Author(s):  
Mette K. Andersen ◽  
Richard A. Larson ◽  
Nils Mauritzson ◽  
Susanne Schnittger ◽  
Suresh C. Jhanwar ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Myelodysplastic Syndromes ◽  
International Workshop ◽  
Chromosome Abnormalities

scholarly journals Chromosome abnormalities in Down's syndrome patients with acute leukemia

Blood ◽  
1981 ◽  
Vol 58 (3) ◽  
pp. 459-466 ◽  
Author(s):  
Y Kaneko ◽  
JD Rowley ◽  
D Variakojis ◽  
RR Chilcote ◽  
JW Moohr ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Early Stage ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Giemsa Stain ◽  
Chromosome Abnormalities ◽  
Leukemic Cells ◽  
Myeloid Differentiation ◽  
Acute Nonlymphocytic Leukemia ◽  
Blast Cells

Abstract Chromosome and cytologic studies were performed on three Down's syndrome (DS) patients with acute nonlymphocytic leukemia (ANLL). All three patients had an aneuploid clone in their leukemic cells: 50, XX, +6, +19, +21, +22, +8, XX, +21, and 47,XY, +8, - 21 +dic(21;21)(p13;p11). Every patient appeared to have acute undifferentiated leukemia when the blast cells were examined with Wright-Giemsa stain; cytochemistry studies, however, showed that the leukemic blasts were in an early stage of myeloid differentiation. The two patients with +8 had a preleukemic phase; the blast cells of the patient with an extra no. 19 and no.22 could not be differentiated morphologically from those of the two patients with an extra no. 8. Our findings and a review of data on 40 other patients suggest that most DS children with ANLL have hyperdiploidy, which is usually related to gains of C, F, and /or G chromosomes, and that the abnormalities of +8 and of +19, +22 in DS children may be associated with acute leukemia (AL) in an early stage of myeloid differentiation.

Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: Report from an International Workshop

2002 ◽  
Vol 33 (4) ◽  
pp. 401-412 ◽  
Author(s):  
AnneMarie W. Block ◽  
Andrew J. Carroll ◽  
Anne Hagemeijer ◽  
Lucienne Michaux ◽  
Kirsten van Lom ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Myelodysplastic Syndromes ◽  
International Workshop ◽  
Chromosome Abnormalities

Chromosome Abnormalities and Prognosis in Childhood Acute Leukemia

1991 ◽  
Vol 33 (4) ◽  
pp. 497-506 ◽  
Author(s):  
Yasuhide Hayashi ◽  
Ryoji Hanada ◽  
Keiko Yamamoto
Keyword(s):  
Acute Leukemia ◽  
Chromosome Abnormalities ◽  
Childhood Acute Leukemia
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