scholarly journals Chromosome abnormalities in Down's syndrome patients with acute leukemia

Blood ◽  
1981 ◽  
Vol 58 (3) ◽  
pp. 459-466 ◽  
Author(s):  
Y Kaneko ◽  
JD Rowley ◽  
D Variakojis ◽  
RR Chilcote ◽  
JW Moohr ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Early Stage ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Giemsa Stain ◽  
Chromosome Abnormalities ◽  
Leukemic Cells ◽  
Myeloid Differentiation ◽  
Acute Nonlymphocytic Leukemia ◽  
Blast Cells

Abstract Chromosome and cytologic studies were performed on three Down's syndrome (DS) patients with acute nonlymphocytic leukemia (ANLL). All three patients had an aneuploid clone in their leukemic cells: 50, XX, +6, +19, +21, +22, +8, XX, +21, and 47,XY, +8, - 21 +dic(21;21)(p13;p11). Every patient appeared to have acute undifferentiated leukemia when the blast cells were examined with Wright-Giemsa stain; cytochemistry studies, however, showed that the leukemic blasts were in an early stage of myeloid differentiation. The two patients with +8 had a preleukemic phase; the blast cells of the patient with an extra no. 19 and no.22 could not be differentiated morphologically from those of the two patients with an extra no. 8. Our findings and a review of data on 40 other patients suggest that most DS children with ANLL have hyperdiploidy, which is usually related to gains of C, F, and /or G chromosomes, and that the abnormalities of +8 and of +19, +22 in DS children may be associated with acute leukemia (AL) in an early stage of myeloid differentiation.

scholarly journals Chromosome abnormalities in Down's syndrome patients with acute leukemia

Blood ◽  
1981 ◽  
Vol 58 (3) ◽  
pp. 459-466 ◽  
Author(s):  
Y Kaneko ◽  
JD Rowley ◽  
D Variakojis ◽  
RR Chilcote ◽  
JW Moohr ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Early Stage ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Giemsa Stain ◽  
Chromosome Abnormalities ◽  
Leukemic Cells ◽  
Myeloid Differentiation ◽  
Acute Nonlymphocytic Leukemia ◽  
Blast Cells

Chromosome and cytologic studies were performed on three Down's syndrome (DS) patients with acute nonlymphocytic leukemia (ANLL). All three patients had an aneuploid clone in their leukemic cells: 50, XX, +6, +19, +21, +22, +8, XX, +21, and 47,XY, +8, - 21 +dic(21;21)(p13;p11). Every patient appeared to have acute undifferentiated leukemia when the blast cells were examined with Wright-Giemsa stain; cytochemistry studies, however, showed that the leukemic blasts were in an early stage of myeloid differentiation. The two patients with +8 had a preleukemic phase; the blast cells of the patient with an extra no. 19 and no.22 could not be differentiated morphologically from those of the two patients with an extra no. 8. Our findings and a review of data on 40 other patients suggest that most DS children with ANLL have hyperdiploidy, which is usually related to gains of C, F, and /or G chromosomes, and that the abnormalities of +8 and of +19, +22 in DS children may be associated with acute leukemia (AL) in an early stage of myeloid differentiation.

scholarly journals Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome

Blood ◽  
1988 ◽  
Vol 72 (1) ◽  
pp. 15-23
Author(s):  
Y Hayashi ◽  
M Eguchi ◽  
K Sugita ◽  
S Nakazawa ◽  
T Sato ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Pediatric Patients ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Myeloproliferative Disorders ◽  
Study Groups ◽  
Electron Microscopic ◽  
Myeloid Progenitor ◽  
Microscopic Studies ◽  
Blast Cells

Cytogenetic, immunologic, and electron microscopic studies were performed on the blast cells of 28 pediatric patients with Down's syndrome, 13 with acute leukemia (DS-AL) and 15 with transient myeloproliferative disorders (DS-TMD). Clonal chromosome abnormalities were found in the cells of all patients with DS-AL but not those with DS-TMD. The younger ages and higher hemoglobin concentrations, platelet counts, and WBC counts of DS-TMD patients provided a clinical contrast with the frankly leukemic cases. Myelodysplastic syndrome, characterized by a small percentage of leukemic blast cells, was observed in 11 of the 13 patients with DS-AL compared with none in the DS-TMD group. Electron microscopy disclosed a positive platelet peroxidase reaction in each of the 11 DS-TMD patients and in nine of the 13 DS-AL patients. Immunologic studies revealed antiplatelet- megakaryocyte antigens on the blast cells of the majority of patients in both study groups. Our findings suggest that the blast cells in cases of DS-AL and DS-TMD arise from cells of the megakaryocytic lineage or from a myeloid progenitor with the capacity for megakaryocytic differentiation. The high risk of the development of AL in patients with DS who are less than 3 years old may be related to increased megakaryocyte proliferation in this age group.

scholarly journals Unusual Inclusions Occurring in the Blasts of Four Patients With Acute Leukemia and Down’s Syndrome

Blood ◽  
1974 ◽  
Vol 44 (5) ◽  
pp. 735-741 ◽  
Author(s):  
Richard D. Brunning ◽  
Janet Parkin ◽  
Fred Dick ◽  
Mark Nesbit
Keyword(s):  
Acute Leukemia ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Virus Like Particles ◽  
Single Membrane ◽  
Blast Cells ◽  
Membrane Bound

Abstract The blast cells from four patients with acute leukemia and Down’s syndrome were found to contain unusual inclusions which manifested similar morphologic and cytochemical characteristics. Ultrastructure studies of the blasts from one of these patients revealed the inclusions to be single membrane-bound structures containing electron-dense amorphous debris, membranous substance, and virus-like particles.

scholarly journals Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome

Blood ◽  
1988 ◽  
Vol 72 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Y Hayashi ◽  
M Eguchi ◽  
K Sugita ◽  
S Nakazawa ◽  
T Sato ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Pediatric Patients ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Myeloproliferative Disorders ◽  
Study Groups ◽  
Electron Microscopic ◽  
Myeloid Progenitor ◽  
Microscopic Studies ◽  
Blast Cells

Abstract Cytogenetic, immunologic, and electron microscopic studies were performed on the blast cells of 28 pediatric patients with Down's syndrome, 13 with acute leukemia (DS-AL) and 15 with transient myeloproliferative disorders (DS-TMD). Clonal chromosome abnormalities were found in the cells of all patients with DS-AL but not those with DS-TMD. The younger ages and higher hemoglobin concentrations, platelet counts, and WBC counts of DS-TMD patients provided a clinical contrast with the frankly leukemic cases. Myelodysplastic syndrome, characterized by a small percentage of leukemic blast cells, was observed in 11 of the 13 patients with DS-AL compared with none in the DS-TMD group. Electron microscopy disclosed a positive platelet peroxidase reaction in each of the 11 DS-TMD patients and in nine of the 13 DS-AL patients. Immunologic studies revealed antiplatelet- megakaryocyte antigens on the blast cells of the majority of patients in both study groups. Our findings suggest that the blast cells in cases of DS-AL and DS-TMD arise from cells of the megakaryocytic lineage or from a myeloid progenitor with the capacity for megakaryocytic differentiation. The high risk of the development of AL in patients with DS who are less than 3 years old may be related to increased megakaryocyte proliferation in this age group.

scholarly journals Leukemia with Down's syndrome: translocation between chromosomes 1 and 19 in acute myelomonocytic leukemia following transient congenital myeloproliferative syndrome

Blood ◽  
1985 ◽  
Vol 66 (6) ◽  
pp. 1466-1468 ◽  
Author(s):  
R Morgan ◽  
F Hecht ◽  
ML Cleary ◽  
J Sklar ◽  
MP Link
Keyword(s):  
Spontaneous Regression ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Myeloproliferative Disorder ◽  
Leukemic Cells ◽  
Immunoglobulin Gene ◽  
Acute Nonlymphocytic Leukemia ◽  
Myeloproliferative Syndrome ◽  
Acute Myelomonocytic Leukemia ◽  
Myelomonocytic Leukemia

Abstract A girl with Down's syndrome was born with a myeloproliferative disorder. The child had spontaneous regression of the myeloproliferation, with acute leukemia developing at a later date. Morphologic, cytochemical, immunologic, and immunoglobulin gene configuration studies all supported the diagnosis of acute nonlymphocytic leukemia. High-resolution chromosome studies revealed that the leukemic cells consistently contained a translocation between chromosomes 1 and 19: der(19)t(1;19)(q25;p13). Spontaneous regression of the transient myeloproliferative syndrome of the newborn with Down's syndrome may not always be permanent, and the transient myeloproliferative syndrome may sometimes represent an early sign of acute nonlymphocytic leukemia.

scholarly journals Leukemia with Down's syndrome: translocation between chromosomes 1 and 19 in acute myelomonocytic leukemia following transient congenital myeloproliferative syndrome

Blood ◽  
1985 ◽  
Vol 66 (6) ◽  
pp. 1466-1468 ◽  
Author(s):  
R Morgan ◽  
F Hecht ◽  
ML Cleary ◽  
J Sklar ◽  
MP Link
Keyword(s):  
Spontaneous Regression ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Myeloproliferative Disorder ◽  
Leukemic Cells ◽  
Immunoglobulin Gene ◽  
Acute Nonlymphocytic Leukemia ◽  
Myeloproliferative Syndrome ◽  
Acute Myelomonocytic Leukemia ◽  
Myelomonocytic Leukemia

A girl with Down's syndrome was born with a myeloproliferative disorder. The child had spontaneous regression of the myeloproliferation, with acute leukemia developing at a later date. Morphologic, cytochemical, immunologic, and immunoglobulin gene configuration studies all supported the diagnosis of acute nonlymphocytic leukemia. High-resolution chromosome studies revealed that the leukemic cells consistently contained a translocation between chromosomes 1 and 19: der(19)t(1;19)(q25;p13). Spontaneous regression of the transient myeloproliferative syndrome of the newborn with Down's syndrome may not always be permanent, and the transient myeloproliferative syndrome may sometimes represent an early sign of acute nonlymphocytic leukemia.

Acute leukemia characterized by trisomy 8 in down's syndrome

Pathology ◽  
1985 ◽  
Vol 17 (1) ◽  
pp. 111-114 ◽  
Author(s):  
Alan F. Broomhead ◽  
Y.L Kwan ◽  
N.A. Zell ◽  
P.R.L. Lam-Po-Tang ◽  
D. O'Gorman Hughes
Keyword(s):  
Acute Leukemia ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Trisomy 8

Additional Chromosome Abnormalities in Transient Abnormal Myelopoiesis in Down’s Syndrome Patients

1997 ◽  
Vol 98 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Shinji Kounami ◽  
Noriyuki Aoyagi ◽  
Hiroshi Tsuno ◽  
Hiroyuki Suzuki ◽  
Naomi Kitano ◽  
...  
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Chromosome Abnormalities ◽  
Transient Abnormal Myelopoiesis ◽  
Additional Chromosome

Effects of Speech and Speech and Sign Instruction on Oral Language Learning and Generalization of Action + Object Combinations by Down's Syndrome Children

1984 ◽  
Vol 49 (3) ◽  
pp. 293-302 ◽  
Author(s):  
Mary Ann Romski ◽  
Kenneth F. Ruder
Keyword(s):  
Language Learning ◽  
Oral Language ◽  
Early Stage ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Treatment Conditions ◽  
Linguistic System ◽  
Object Relational ◽  
Sign Conditions ◽  
Level Performance

This study was designed to compare the effects of speech and speech-plus-sign stimulation during comprehension treatment on the oral language learning and generalization of action + object relational meanings. Ten home-reared Down's syndrome children in Early Stage I received concurrent comprehension treatment in Speech and Speech-Sign conditions using a miniature linguistic system. Upon attainment of criterion level performance in both conditions, generalization tasks were administered to measure the effects of the comprehension treatment on the comprehension and the production of treated and untreated action + object combinations. The results obtained from this study indicated that the two treatment conditions did not differ significantly for either learning or generalization. The data did, however, indicate that individual patterns of acquisition were evident among the children. Caution is advised concerning the automatic adoption or rejection of manual sign as part of oral language intervention programs.

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