Identification of Regions of the Epidermal Growth Factor Receptor Involved in Ligand Binding Specificity Using a High Affinity Form of the Ectodomain

Growth Factor ◽

Epidermal Growth Factor ◽

Ligand Binding ◽

Growth Factor Receptor ◽

Binding Specificity ◽

High Affinity ◽

Identification of a Determinant of Epidermal Growth Factor Receptor Ligand-Binding Specificity Using a Truncated, High-Affinity Form of the Ectodomain

Biochemistry ◽

10.1021/bi010037b ◽

2001 ◽

Vol 40 (30) ◽

pp. 8930-8939 ◽

Cited By ~ 65

Author(s):

Thomas C. Elleman ◽

Teresa Domagala ◽

Neil M. McKern ◽

Maureen Nerrie ◽

Björn Lönnqvist ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Ligand Binding ◽

Growth Factor Receptor ◽

Binding Specificity ◽

Receptor Ligand ◽

High Affinity ◽

Immunohistochemical assay for epidermal growth factor receptor on paraffin-embedded sections: validation against ligand-binding assay and clinical relevance in breast cancer

British Journal of Cancer ◽

10.1038/bjc.1995.239 ◽

1995 ◽

Vol 71 (6) ◽

pp. 1237-1242 ◽

Cited By ~ 23

Author(s):

JC Newby ◽

RP A'Hern ◽

RD Leek ◽

IE Smith ◽

AL Harris ◽

...

Keyword(s):

Breast Cancer ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Ligand Binding ◽

Binding Assay ◽

Growth Factor Receptor ◽

Ligand Binding Assay ◽

Immunohistochemical Assay ◽

Biofunctional polystyrene derivatives exhibit a high affinity for the epidermal growth factor-receptor (EGF-R): Part I

Journal of Materials Science Materials in Medicine ◽

10.1007/bf00058721 ◽

1996 ◽

Vol 7 (2) ◽

pp. 103-107 ◽

Cited By ~ 1

Author(s):

R. Siali ◽

J. Correia ◽

G. Pavon-Djavid ◽

M. Jozefowicz

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

High Affinity ◽

Ligand binding induces a conformational change in epidermal growth factor receptor dimers

Growth Factors ◽

10.3109/08977194.2012.739619 ◽

2012 ◽

Vol 30 (6) ◽

pp. 394-409 ◽

Cited By ~ 16

Author(s):

Francesca Walker ◽

Julie Rothacker ◽

Christine Henderson ◽

Edouard C. Nice ◽

Bruno Catimel ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Ligand Binding ◽

Conformational Change ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Receptor Dimers

Nimotuzumab, an Antitumor Antibody that Targets the Epidermal Growth Factor Receptor, Blocks Ligand Binding while Permitting the Active Receptor Conformation

Cancer Research ◽

10.1158/0008-5472.can-08-4518 ◽

2009 ◽

Vol 69 (14) ◽

pp. 5851-5859 ◽

Cited By ~ 99

Author(s):

Ariel Talavera ◽

Rosmarie Friemann ◽

Silvia Gómez-Puerta ◽

Carlos Martinez-Fleites ◽

Greta Garrido ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Ligand Binding ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Receptor Conformation ◽

Antitumor Antibody

A Deletion Mutation within the Ligand Binding Domain Is Responsible for Activation of Epidermal Growth Factor Receptor Gene in Human Brain Tumors

Japanese Journal of Cancer Research ◽

10.1111/j.1349-7006.1990.tb02644.x ◽

1990 ◽

Vol 81 (8) ◽

pp. 773-779 ◽

Cited By ~ 92

Author(s):

Hitoshi Yamazaki ◽

Yoshito Ohba ◽

Norikazu Tamaoki ◽

Masabumi Shibuya

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Brain Tumors ◽

Ligand Binding ◽

Human Brain ◽

Receptor Gene ◽

Growth Factor Receptor ◽

Human Brain Tumors ◽

Mitosis-specific Negative Regulation of Epidermal Growth Factor Receptor, Triggered by a Decrease in Ligand Binding and Dimerization, Can Be Overcome by Overexpression of Receptor

10.1074/jbc.272.30.18656 ◽

1997 ◽

Vol 272 (30) ◽

pp. 18656-18665 ◽

Cited By ~ 45

Author(s):

Nobutaka Kiyokawa ◽

Eun Kyung Lee ◽

Devarajan Karunagaran ◽

Shiaw-Yih Lin ◽

Mien-Chie Hung

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Ligand Binding ◽

Growth Factor Receptor ◽

Negative Regulation ◽

Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro.

10.1016/s0021-9258(19)50057-6 ◽

1992 ◽

Vol 267 (15) ◽

pp. 10588-10595 ◽

Cited By ~ 3

Author(s):

R.B. Birge ◽

J.E. Fajardo ◽

B.J. Mayer ◽

H Hanafusa

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Affinity Binding ◽

High Affinity Binding ◽

High Affinity ◽

Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factor.

10.1016/s0021-9258(18)49908-5 ◽

1991 ◽

Vol 266 (5) ◽

pp. 2746-2752 ◽

Cited By ~ 1

Author(s):

F Walker ◽

A W Burgess

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

High Affinity ◽

Synthesis of epidermal growth factor receptor in human A431 cells. Glycosylation-dependent acquisition of ligand binding activity occurs post-translationally in the endoplasmic reticulum.

10.1016/s0021-9258(18)66858-9 ◽

1986 ◽

Vol 261 (32) ◽

pp. 15233-15241 ◽

Cited By ~ 12

Author(s):

L J Slieker ◽

T M Martensen ◽

M D Lane

Keyword(s):

Endoplasmic Reticulum ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Ligand Binding ◽

Growth Factor Receptor ◽

Binding Activity ◽

A431 Cells ◽

Epidermal Growth ◽

Ligand Binding Activity