Reduction in Dopaminergic Activity in the Rat Carotid Body after Acute or Chronic Almitrine

1987 ◽  
pp. 378-385 ◽  
Author(s):  
J. M. Pequignot ◽  
E. Tavitian ◽  
C. Boudet ◽  
L. Peyrin
Keyword(s):  
Carotid Body ◽  
Dopaminergic Activity

Inhibitory effect of almitrine on dopaminergic activity of rat carotid body

1987 ◽  
Vol 63 (2) ◽  
pp. 746-751 ◽  
Author(s):  
J. M. Pequignot ◽  
E. Tavitian ◽  
C. Boudet ◽  
Y. Evrard ◽  
J. Claustre ◽  
...  
Keyword(s):  
Carotid Body ◽  
Inhibitory Effect ◽  
Utilization Rate ◽  
Dopaminergic Activity ◽  
Catecholamine Biosynthesis ◽  
Peripheral Arterial ◽  
Dose Dependent

Almitrine increases ventilation by stimulating the peripheral arterial chemoreceptors. This study assessed the effects of acute and chronic almitrine treatments on the dopamine (DA) and norepinephrine (NE) contents and utilization rates in the rat carotid body. Almitrine (5 mg/kg ip) caused a 34% reduction in DA content after 30 min. Extending the almitrine treatment for 15 days (one daily ip injection) produced a further progressive diminution in DA stores (-55%; P less than 0.01). The utilization rate of DA measured after inhibiting catecholamine biosynthesis by alpha-methyl-p-tyrosine was strongly reduced by almitrine (-98% after 15 days; P less than 0.01). The effects of almitrine were dose dependent. The noradrenergic activity was much less altered by the drug. The data showed that almitrine can modify the dynamics of DA in rat carotid body producing a decrease in both content and utilization rate.

Fine Structure of Carotid Body: Normal and Anoxic Cats

1967 ◽  
Vol 25 ◽  
pp. 150-151
Author(s):  
Fadhil Al-Lami ◽  
R.G. Murray
Keyword(s):  
Fine Structure ◽  
Adrenal Medulla ◽  
Carotid Body ◽  
Uranyl Acetate ◽  
Lead Citrate ◽  
Glomus Cells ◽  
Sustentacular Cells ◽  
Carotid Bodies

Although the fine structure of the carotid body has been described in several recent reports, uncertainties remain, and the morphological effects of anoxia on the carotid body cells of the cat have never been reported. We have, therefore, studied the fine structure of the carotid body both in normal and severely anoxic cats, and to test the specificity of the effects, have compared them with the effects on adrenal medulla, kidney, and liver of the same animals. Carotid bodies of 50 normal and 15 severely anoxic cats (9% oxygen in nitrogen) were studied. Glutaraldehyde followed by OsO4 fixations, Epon 812 embedding, and uranyl acetate and lead citrate staining, were the technics employed.We have called the two types of glomus cells enclosed and enclosing cells. They correspond to those previously designated as chemoreceptor and sustentacular cells respectively (1). The enclosed cells forming the vast majority, are irregular in shape with many processes and occasional peripheral densities (Fig. 1).

Onyx Embolization of Carotid Body Paragangliomas: An Adjunct to Safe and Effective Surgical Resection

2013 ◽  
Vol 74 (S 01) ◽  
Author(s):  
Felipe Albuquerque ◽  
Cameron McDougall ◽  
Robert Spetzler ◽  
Andrew Ducruet ◽  
Webster Crowley ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Carotid Body

Presentation with Personality changes and Tinnitus to a Vascular Intervention: Rare case of Carotid Body Paraganglioma

2018 ◽  
pp. e000109
Author(s):  
Ahsan Zil-E-Ali ◽  
Zubair Ahmed ◽  
Amber Ehsan Faquih ◽  
Muhammad Ishaq ◽  
Muhammad Aadil
Keyword(s):  
Case Report ◽  
Carotid Body ◽  
Neuroendocrine Neoplasms ◽  
Vascular Surgeon ◽  
Vascular Intervention ◽  
Presenting Symptoms ◽  
Personality Changes ◽  
Tender Mass ◽  
Carotid Body Tumors ◽  
General Physical

Background: Carotid body paragangliomas are rare neuroendocrine neoplasms of chromaffin negative glomus cells. This case report explains an atypical case with unusual presentation and treatment. Case Report: A healthy smoker technician by profession was brought to the emergency room (ER) with coprolalia. The general physical exam did not reveal any information. His history revealed unilateral tinnitus and odynophagia leading to a consultation by the neurologist with head imaging. Acoustic neuroma was ruled out and the caregiver was asked to elaborate the events mentioned in the history and a psychiatric examination was done. The personality changes were evaluated by the psychiatrist that showed overlapping of delirium and depression. The patient was further examined by a vascular surgeon. After careful revisiting of the history, examination and indication of tender mass in the neck by the patient's vascular surgeon, the diagnosis of carotid body paraganglioma was made which was followed by surgical resection for treatment. Conclusion: Carotid Body Paragangliomas are very vascular structures and their manipulation in a surgery setting requires expertise. This case presented with personality changes and tinnitus, a very less likely event to occur in a carotid body tumor. The present care report, thus adds on to the literature of carotid body tumors and its presenting symptoms.

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