Occupational Exposure to Aluminum and Cognitive Impairment

2018 ◽  
pp. 85-97 ◽  
Author(s):  
Xiaoting Lu
Keyword(s):  
Cognitive Impairment ◽  
Occupational Exposure

Association Between Occupational Exposure to Formaldehyde and Cognitive Impairment

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000013146
Author(s):  
Noemie Letellier ◽  
Laure-Anne Gutierrez ◽  
Corinne Pilorget ◽  
Fanny Artaud ◽  
Alexis Descatha ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Occupational Exposure ◽  
Exposure Duration ◽  
Dose Effect ◽  
Cumulative Exposure ◽  
Cognitive Score ◽  
Cognitive Domains ◽  
Recent Exposure ◽  
Formaldehyde Exposure

Objective:To our knowledge, no study has investigated the effect of exposure to formaldehyde on cognition in the general population. Our objective was to examine the association between occupational exposure to formaldehyde and cognitive impairment in middle-aged and young- old adults (≥45 years).Methods:In the French CONSTANCES cohort, cognitive function was assessed with a standardized battery of seven cognitive tests to evaluate global cognitive function, episodic verbal memory, language abilities and executive functions (e.g., Digit Symbol Substitution Test, DSST). A global cognitive score was created using principal component analysis. Cognitive impairment was assessed in reference to norms of neuropsychological battery according to age, sex and education. Lifetime exposure to formaldehyde was assessed using a French job-exposure matrix created in the framework of the Matgéné project. After performing multiple imputation, separate modified Poisson regression models were used to evaluate the association between cognitive impairment (<25th percentile) and formaldehyde exposure (exposed/never exposed), exposure duration, cumulative exposure index (CEI), and combination of CEI and time of last exposure.Results:Among 75 322 participants (median age: 57.5 years, women: 53%), 8% were exposed to formaldehyde during their professional life. These participants were at higher risk of global cognitive impairment (for global cognitive score: adjusted relative risk, aRR, 1.17, 95% confidence interval, CI: 1.11-1.23), after adjusting for confounders (age, sex, education, income, solvent exposure, Effort–Reward Imbalance, night-shift, repetitive, and noisy work). They were at higher risk of cognitive impairment for all cognitive domains explored. Longer exposure duration and high CEI were associated with cognitive impairment, with a dose-effect relationship for exposure duration. Recent exposure was associated with impairment in all cognitive domains. Time did not fully attenuate formaldehyde-associated cognitive deficits especially in highly exposed individuals (for DSST: high past exposure aRR 1.23, 95%CI: 1.11-1.36; high recent exposure: aRR 1.24, 95%CI: 1.13-1.35).Conclusion:Our findings highlight the long-term detrimental effect of formaldehyde exposure on cognitive health in a relatively young population.

scholarly journals Occupational exposure as a risk factor for cognitive impairment in Vietnamese nail salon workers

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Thuc‐Nhi Nguyen ◽  
Mai Tram Nguyen ◽  
Shuai Chen ◽  
Ladson Hinton
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Occupational Exposure ◽  
Nail Salon ◽  
Nail Salon Workers

Association of Occupational Factors and Dementia or Cognitive Impairment: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 78 (1) ◽  
pp. 217-227 ◽  
Author(s):  
Liang-Yu Huang ◽  
He-Ying Hu ◽  
Zuo-Teng Wang ◽  
Ya-Hui Ma ◽  
Qiang Dong ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Occupational Exposure ◽  
Random Effect ◽  
Excess Risk ◽  
Mental Work ◽  
Field Exposure ◽  
Occupational Factors ◽  
Work Complexity ◽  
Fold Excess ◽  
Reduced Risk

Background: Several existing studies have reported that occupational factors might play an important part in cognitive function with aging. Objective: We aim to explore the associations between modifiable occupational factors and risk of dementia or mild cognitive impairment (MCI). Methods: Adopting random-effect models, this study conducted primary analyses for all occupational factors and subgroup analyses for the effect of occupation type based on prospective cohort and case-control studies searched from PubMed and EMBASE databases up to March 2020. Results: Among the 38,111 identified literatures, 9 studies on occupation type, 4 studies on work complexity, and 30 studies on occupational exposure were included. In terms of occupation type, mental work conferred a 44% reduced risk (95% CI = 0.34–0.94, I² = 85.00%, p < 0.01) for MCI. In terms of work complexity, higher work complexity conferred a 5% reduced risk (95% CI = 0.91–1.00, I² = 57.00%, p < 0.01) for dementia. In terms of occupational exposure, high strain and passive job in the longest-held job conferred a 1.21- and 1.15-fold excess risk (95% CI = 1.05–1.39 I² = 62.00%, p < 0.05; 95% CI = 1.05–1.26 I² = 31.00%, p = 0.23; respectively) of cognitive decline. Besides, magnetic field exposure conferred a 1.26-fold excess risk (95% CI = 1.01–1.57, I² = 69.00%, p < 0.01) for dementia. Conclusion: Novel prevention strategies based on occupational factors may hold promise against dementia and MCI.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Toward Identifying Mild Cognitive Impairment in Hispanic and African American Adults

2017 ◽  
Vol 2 (2) ◽  
pp. 110-116
Author(s):  
Valarie B. Fleming ◽  
Joyce L. Harris
Keyword(s):  
Older Adults ◽  
African American ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Healthcare Access ◽  
Communication Disorders ◽  
Healthcare Systems ◽  
Prevention Education ◽  
Education Management ◽  
African American Adults

Across the breadth of acquired neurogenic communication disorders, mild cognitive impairment (MCI) may go undetected, underreported, and untreated. In addition to stigma and distrust of healthcare systems, other barriers contribute to decreased identification, healthcare access, and service utilization for Hispanic and African American adults with MCI. Speech-language pathologists (SLPs) have significant roles in prevention, education, management, and support of older adults, the population must susceptible to MCI.

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