Gas channeling is tending to happen in CO2 immiscible flooding process, and that would seriously influence gas injection development. In order to plugging gas channeling channel effectively, improve inspiration and production profile, and enhance swept volume and oil displacement efficiency of the gas injection, field trials of foam seal channeling are carried out. The tests showed that carbon dioxide foam can effectively plugging the gas channeling channel, expand the swept volume of carbon dioxide gas, reduce invalid circulation, and enhancing oil displacement efficiency. The anti-sealing channeling technology is cost-efficient, and it is suitable for Daqing peripheral low permeability oil field on gas injection development. It has good prospects, and it will provide a strong technical support on gas injection development of low permeability reservoir.