The Role of Reactive Oxygen Species on Cellular Fate and Function of Tumor-Infiltrating Lymphocytes

2021 ◽  
pp. 1-19
Author(s):  
Lakshmi R. Perumalsamy ◽  
Sanjana Rajgopal ◽  
Tapasya K ◽  
Sherine Joanna Fredrick ◽  
Arun Dharmarajan
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Tumor Infiltrating Lymphocytes ◽  
Oxygen Species ◽  
And Function ◽  
Infiltrating Lymphocytes ◽  
Cellular Fate

The Role of Reactive Oxygen Species in Integrin and Matrix Metalloproteinase Expression and Function

2008 ◽  
Vol 49 (3-4) ◽  
pp. 197-202 ◽  
Author(s):  
Gunbjørg Svineng ◽  
Chandra Ravuri ◽  
Oddveig Rikardsen ◽  
Nils-Erik Huseby ◽  
Jan-Olof Winberg
Keyword(s):  
Reactive Oxygen Species ◽  
Matrix Metalloproteinase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
And Function

The Role of Reactive Oxygen Species in Tumor Treatment and its Impact on Bone Marrow Hematopoiesis

2020 ◽  
Vol 21 (5) ◽  
pp. 477-498
Author(s):  
Yongfeng Chen ◽  
Xingjing Luo ◽  
Zhenyou Zou ◽  
Yong Liang
Keyword(s):  
Reactive Oxygen Species ◽  
Bone Marrow ◽  
Oxidative Damage ◽  
Tumor Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tumor Treatment ◽  
Normal Cells ◽  
Treatment And Prevention

Reactive oxygen species (ROS), an important molecule inducing oxidative stress in organisms, play a key role in tumorigenesis, tumor progression and recurrence. Recent findings on ROS have shown that ROS can be used to treat cancer as they accelerate the death of tumor cells. At present, pro-oxidant drugs that are intended to increase ROS levels of the tumor cells have been widely used in the clinic. However, ROS are a double-edged sword in the treatment of tumors. High levels of ROS induce not only the death of tumor cells but also oxidative damage to normal cells, especially bone marrow hemopoietic cells, which leads to bone marrow suppression and (or) other side effects, weak efficacy of tumor treatment and even threatening patients’ life. How to enhance the killing effect of ROS on tumor cells while avoiding oxidative damage to the normal cells has become an urgent issue. This study is a review of the latest progress in the role of ROS-mediated programmed death in tumor treatment and prevention and treatment of oxidative damage in bone marrow induced by ROS.

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