The internet of things (IoT) involves connections of physical things to the internet. It is largely about the relationships between things, or non-human actors. In the past, it was rare for non-humans to interact with each other without any involvement by humans, but this has changed and the “things” sometimes seem to have inordinate power. Where does this leave humans? Are the things taking over? As a consideration of interactions like this must be a socio-technical one, in this chapter, the authors make use of actor-network theory to frame the discussion. While the first applications for IoT technology were in areas such as supply chain management and logistics, many more examples now can be found ranging from control of home appliances to healthcare. It is expected that the “things” will become active participants in business, information, and social processes, and that they will communicate among themselves by exchanging data sensed from the environment, while reacting autonomously.