Pixel-Based Nuclei Segmentation in Fine Needle Aspiration Cytology of Lung Lesions

Introduction: Following the first study of Computed tomography guided trans thoracic biopsy of lung lesion by Haaga and Alfidi in 1976, CT guided transthoracic biopsy has been widely used for confirming the diagnosis of suspicious lung lesions. This study is aimed to assess the effectiveness of Transthoracic percutaneous fi ne needle aspiration cytology and frequency of associated complications. Methods: A retrospective, hospital based study was performed between 11/06/2008 and 1/12/2009 at Department of Radiology, Shree Birendra Hospital, Kathmandu, Nepal. Thirty nine consecutive cases of lung lesions who underwent Trans Thoracic Percutaneous Fine Needle Aspiration Cytology (TTFNAC) under CT guidance were analysed. Smears of the aspirated material were evaluated by the pathology consultant (cytopathological evaluation) for adequacy. Results: There was adequate material for a cytopathological diagnosis in thirty four (87.18 %) cases. Two cases were hemorrhagic while three cases revealed only reactive cells thus inadequate and non representative case constituted (12.8 %). Eight cases were reported as benign (23.53 %). Twenty three samples (67.65%) were reported as definite malignant cases and three cases (8.82%) showed atypical cells, suggestive of malignancy. Squamous cell carcinoma was the single most frequent histological diagnosis (12 cases). Conclusions: The FNAC of lung is useful, safe and economical technique providing 87% diagnostic accuracy for lung mass without significant increase in complications. Medical Journal of Shree Birendra Hospital; Jan-June 2012/vol.11/Issue1/37-41 DOI: http://dx.doi.org/10.3126/mjsbh.v11i1.7766

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Evaluation of intrathoracic lesions by image guided fine needle aspiration cytology

Journal of Pathology of Nepal ◽

10.3126/jpn.v9i1.23363 ◽

2019 ◽

Vol 9 (1) ◽

pp. 1464-1468

Author(s):

Manisha Shrestha ◽

Shovana Karki ◽

Gita Sayami

Keyword(s):

Fine Needle Aspiration ◽

Predictive Value ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Lung Lesions ◽

Fine Needle ◽

Image Guided ◽

Neoplastic Lesions ◽

Needle Aspiration Cytology

Background: Fine needle aspiration cytology has become an indispensable tool for diagnosis of intrathoracic lesions. The purpose of this study was to evaluate the spectrum of intrathoracic lesions by image guided fine needle aspiration cytology. Materials and Methods: This was a prospective study of 100 patients, who underwent image guided fine needle aspiration cytology of intrathoracic lesions from December 2015 to November 2016 in the Department of Pathology, Institute of Medicine, Tribhuwan University Teaching Hospital. Results: Of the 100 cases, diagnostic material was obtained in 86 cases, which included 69 cases (80.23%) from lung, 7 cases (8.13%) from pleura and 10 cases (11.62%) from mediastinum. Lung lesions constituted of 61 neoplastic lesions (88.40%), 3 cases (4.34%) suspicious of malignancy, 3 cases (4.34%) negative for malignancy and 2 non- neoplastic lesions (2.89%). Squamous cell carcinoma was the most common lesion of the lung. Pleural lesions consisted of 5 neoplastic cases (71.42%), 1 non- neoplastic case (14.28%) and 1 negative for malignancy (14.28%). Mediastinal lesions consisted of 7 neoplastic lesions (70.00%) and 3 non- neoplastic lesions (30.00%). Biopsy for histopathological examination was available in 30 cases. The concordance of diagnosis of lung lesions by fine needle aspiration cytology and histopathology was 90.90%. Image guided FNAC had sensitivity of 95.83% and specificity of 50.33% in diagnosing intrathoracic lesions. The positive predictive value of image guided FNAC in diagnosis of intrathoracic lesions was 92.00% and negative predictive value of 66.67 percent. Conclusions: Image guided fine needle aspiration cytology of intrathoracic lesions permits categorization and distinction between non- neoplastic and neoplastic lesions.

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OUTCOMES OF CT FLUOROSCOPY GUIDED FINE-NEEDLE ASPIRATION CYTOLOGY AND CORE NEEDLE BIOPSIES IN SOLITARY LUNG LESIONS

10.36106/ijsr/7645669 ◽

2021 ◽

pp. 18-21

Author(s):

Bishwajit Bhowmik ◽

Syeeda Showkat ◽

Nusrat Ghafoor ◽

Deepak Kumar Verma ◽

Fahmida Sharmin ◽

...

Keyword(s):

Risk Factors ◽

Diagnostic Accuracy ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Complication Rates ◽

Aspiration Cytology ◽

Lung Lesions ◽

Fine Needle ◽

Needle Aspiration Cytology

Introduction: The frequent and widespread use of imaging in clinical practice, particularly CT, has led to a steep increase in incidental ndings of asymptomatic solitary pulmonary nodules. In this situation, histocytopathological analysis is needed to conrm the diagnosis by CTguided biopsy / FNAC. So, the researcher purposively, designed this study. The aim of this study was to assess the outcomes of CT-Guided Fine-Needle Aspiration Cytology and Core Needle Biopsies of Solitary Lung Lesions. CT-uoroscopy guidance helps in this process by accurate needle positioning thus increase the success rate. Materials and Methods: This was a retrospective study conducted at the Department of Radiology & Imaging in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, during January 2017 to January 2019.Atotal of 270 patients who were referred to the Department of Radiology& Imaging for the evaluation of suspicious solitary lung lesions after the detection of a solitary pulmonary nodule in X-ray or CT scan, were included in this study. The results of CT uoroscopy–guided biopsy and FNAC for the included patients were analyzed to determine the diagnostic accuracy, complication rates, and independent risk factors for diagnostic failure and severe pneumothorax in this study. The factors related to the patients' solitary lesions, and procedures were evaluated by univariate analyses using the twosided Student t test for numeric values and Chi-squared test for categorical values where p<0.05 considered as signicant. Statistical analysis were performed using SPSS, version-23.0.Results: Diagnostic accuracy rate was 95.86%, failure was 4.14%, the overall sensitivity was 92.96%, specicity was 85.23% and the statistically signicant risk factors wereage (p=0.001), sex(p=0.001), smoking stats(p=0.001) emphysema(p=0.001),benign lesions(p=0.001),positioning of the patient for the procedure(p=0.001),location of the lesion(p=0.001) lesion size(p=0.001) pneumothorax (p=0.001) and length from the pleura to the lesion of 1.5 cm or greater,(p=0.001).Pneumothorax requiring drainage occurred in 1.48% of patients. The potential risk factors for pneumothorax requiring drainage were age of 73 years, the presence of emphysema, lesion size ≤ 2.0 cm and length from pleura to lesion of ≥ 1.5 cm. The major complications were being observed pneumothorax 15(5.63%), haemoptysis16 (6.01%), and hemothorax 03(1.12%).Conclusion: CT-Fluoroscopy Guided Fine-Needle Aspiration Cytology and biopsy has a high diagnostic accuracy; complication rates were acceptable and comparable to those of previous studies.

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