Management of Eyelid Retraction in Active TED

2020 ◽  
pp. 61-70
Author(s):  
Milind N. Naik
Keyword(s):  
Eyelid Retraction

scholarly journals Outcomes of surgery for epiblepharon accompanied with lower eyelid retraction secondary to buphthalmos in children

2021 ◽  
Author(s):  
Wenhong Cao ◽  
Yuan Wang ◽  
Li Li ◽  
Yunwei Fan ◽  
Wen Liu ◽  
...  
Keyword(s):  
Lower Eyelid ◽  
Eyelid Retraction

The Treatment of Post-blepharoplasty Lower Eyelid Retraction

2021 ◽  
Vol 29 (2) ◽  
pp. 291-300
Author(s):  
Kenneth D. Steinsapir ◽  
Samantha Steinsapir
Keyword(s):  
Lower Eyelid ◽  
Eyelid Retraction

scholarly journals Steroid-Resistant Graves’ Orbitopathy Treated with Tocilizumab in Real-World Clinical Practice: A 9-Year Single-Center Experience

2021 ◽  
Vol 10 (4) ◽  
pp. 706
Author(s):  
José V. Pérez-Moreiras ◽  
María Varela-Agra ◽  
M. Consuelo Prada-Sánchez ◽  
Guillermo Prada-Ramallal
Keyword(s):  
Adverse Drug Reactions ◽  
Disease Recurrence ◽  
Clinical Activity ◽  
Eyelid Retraction ◽  
Single Center ◽  
Drug Reactions ◽  
Steroid Resistant ◽  
Single Center Experience ◽  
Graves Orbitopathy ◽  
The Absolute

This study aimed to assess the effectiveness and safety of tocilizumab use for the treatment of active steroid-resistant Graves’ orbitopathy (GO). A retrospective longitudinal study was conducted by reviewing the medical records at a single center between November 2009 and December 2018. A total of 114 patients with steroid-resistant Graves’ orbitopathy were examined and treated with tocilizumab, of which 54 adults met the inclusion criteria. No concomitant medication for the treatment of orbitopathy was used. The main primary outcomes included changes from baseline in the Clinical Activity Score (CAS) and thyrotropin receptor antibody (TRAb) levels throughout therapy with tocilizumab. The absolute responses to treatment were defined as the achievement of CAS ≤ 1 and TRAb ≤ 10 U/L. A composite ophthalmic score including CAS, proptosis, eyelid retraction, and diplopia was used to evaluate individual improvement in GO. Adverse drug reactions were also assessed. Analysis of the patient’s CAS and TRAb levels showed meaningful reductions during tocilizumab treatment. Differences between values at baseline and subsequent time points were statistically significant (p < 0.001 for all comparisons). The absolute CAS response (CAS = 0 or 1) was achieved in 74% (37/50) of patients after the fourth dose of tocilizumab (at week 16), with a TRAb response being achieved in 55% (23/42) of patients. The relative CAS response (reduction ≥ 2 points) was achieved in 90.9% of patients (40/44) after the first dose of tocilizumab (at week 4). Measurements of proptosis (reduction ≥ 2 mm in 78% of patients, 42/54) and eyelid retraction (reduction ≥ 2 mm in 75%, 33/44), and the prevalence of diplopia (improvement in 68%, 19/28) were significantly reduced after the last dose of tocilizumab (p < 0.001 for all comparisons). GO improved in 98% (53/54) of patients when at least two criteria of the composite evaluation were required. Four patients exhibited disease recurrence, defined as an increase in CAS of ≥2 points in the six months following the date of inactivation. Most adverse drug reactions were mild or moderate in severity. In conclusion, our data suggest that a course of at least 4 months (one monthly dose) of tocilizumab therapy provides a significant benefit to patients with active moderate-to-severe steroid-resistant GO.

Antibodies against Calsequestrin and Type XIII Collagen are Good Markers for Chronic Upper Eyelid Retraction

2007 ◽  
Vol 15 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Bamini Gopinath ◽  
Cherie-Lee Adams ◽  
Reilly Musselman ◽  
Junichi Tani ◽  
Jack R. Wall
Keyword(s):  
Eyelid Retraction ◽  
Upper Eyelid ◽  
Type Xiii Collagen ◽  
Upper Eyelid Retraction

scholarly journals Eyelid Retraction in Isolated Unilateral Congenital Blepharoptosis

2017 ◽  
Vol 8 ◽  
Author(s):  
Michael S. Salman ◽  
Ian H. Clark
Keyword(s):  
Eyelid Retraction

Treatment of Severe Lower Eyelid Retraction with Scleral and Free Skin Grafts and Bipedicle Orbicularis Flap

1990 ◽  
Vol 21 (3) ◽  
pp. 167-172
Author(s):  
Jeffrey J Hurwitz ◽  
Kathleen F Archer ◽  
Joseph S Gruss
Keyword(s):  
Lower Eyelid ◽  
Skin Grafts ◽  
Eyelid Retraction
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